André Nadler

That sounds spicy. Will certainly look.

Congratulations!!

Talks are done... let the fun begin!!! 🍻

Pit stop for clam chowder and lobster rolls 🦞 with the Dresden #lipidtime crew en route to Waterville Valley, NH for the Molecular & Cell Biology of Lipids meeting! @nadlerlab.bsky.social @tcjea.bsky.social @anh-nhn.bsky.social

New preprint from @morielab.bsky.social: tardigrades are super resistant to DNA insult, yet are not immortal. We asked: why & how do they die? We have discovered their Achilles’ heel! Check it to know (spoiler: it has to do of course with DNA… but also lipids!! 😍)

www.biorxiv.org/cgi/content/...

Nicht nur an Unis...

🤣

Man kann halt die Stellenzahl insgesamt verringern. Aber wenn das der Plan ist, sollte es auch klar kommuniziert werden.

Fig. 4. Time-lapse FLIM analysis and hit detection Fiji macro. (A) Stitched multi-tile intensity image overlay with the fluorescence lifetime image. The lifetime image can be either average photon arrival times (‘Fast FLIM’) or calculated average lifetimes from two lifetime components. Ratiometric images can also be used. Scale bar: 1000 μm. Inset: Left – Zoom-in of lifetime image of cells after stimulation with isoproterenol; Right – Zoom-in showing cell segmentation as outlines. Scale bar: 100 μm. (B) Lifetime time traces of all 298 segmented cells in a single tile of Cos7 cells (a mix of ADRB2 KO and WT cells). Cells are stimulated with 40 nM isoproterenol (IsoP), followed by a calibration with forskolin (Forsk). Stimulation and calibration time points may be automatically calculated from the average of all traces (thick black line) or entered manually. (C) The script generates several informative visualizations. Shown are a ‘kymograph’ representation of fluorescence lifetime vs time in all cells, sorted on response magnitude (top- left); a normalized data density graph (2D histogram of lifetime vs time, with cell counts in false color), convenient when analysing thousands of cells (bottom); and (optionally animated) histograms of the fluorescence lifetimes over time (middle) and scatterplots of lifetime vs secondary parameters like cell intensity, cell area or intensity of an additional fluorescence channel of choice (top-right). (D) Hit selection dialog showing various optional criteria. These can be used separately or combined, allowing to screen for a large variety of dynamic phenotypes. (E) Based on the criteria, hit cells are determined and visualized through a ‘hits only’ lifetime traces plot (left). Blue vertical lines indicate the chosen hit detection time window. The hit cells are outlined with white lines on the lifetime-intensity overlay image (right). (F) Additional visualizations of hit cells (left) and non-hit cells (right), in density graphs, resp…

Beyond Static Screens: A High-Throughput Pooled Imaging CRISPR Platform for Dynamic Phenotype Discovery by Kees Jalink and team: www.biorxiv.org/content/10.1...

So sehr ich kürzere PostDoc-Phase und mehr Dauerstellen gut finde... da ist mal wieder sehr wenig von der Finanzierung die Rede. Und die Hoffnung, dass man auf die Weise Geld spart... wishful thinking imho.

Proud to share our first lab pre-print: “SND3 is the membrane insertase within a fungal multipass translocon” where @tzujingyang.bsky.social solved the structure of a ribosome-associated SND3-translocon complex involved in ER membrane protein insertion ➡️ doi.org/10.1101/2025...

Congratulations!!

I was referring to the success rate that submitted grants by men & women have (which is about equal) - not the % of grants awarded to men and women, where about 2/3 go to men due to much higher number of submissions by male applicants

The problem is not the Emmy Noether program - male and female success rates are rather similar and have been for a long time. The problem is that we fail to keep successful women in academia. Many reasons, one being that it takes a decade+ to land a permanent job after the PhD in the best case.

Do you like developing new AI vision methods for microscopy image analysis? You love theory & implementation? 1 week left to apply for a fully funded PhD position in our lab in Dresden 🇩🇪! Topics: object detection/tracking, multimodal models & more. DM/email for details! #PhD #AcademicJobs #GPUsgoBrr

Come work at Nature Methods! A dream job. I know from experience 😄

Congrats! Really well deserved!!

Check out how we became "accidental immunologists"! Wonderful 🧵 from Carmen who has led this project for the past 4 years! Thanks to Xiaolei Su (Yale) for scientific support and @hfspo.bsky.social for the financial support and for allowing us to step out of our comfort zone!

Congratulations!!!

Yes I know.

Looking forward to meeting you all tomorrow!

That is a major improvement. Congrats!

SNAP-tag2 for faster and brighter protein labeling - Nature Chemical Biology SNAP-tag is a widespread tool for labeling protein for bioimaging. Now, Kühn et al. report SNAP-tag2 with increased labeling kinetics and brightness, which translates into a better performance in live...

Finally out in Nature Chem Bio:
SNAP-tag2 for faster and brighter protein labeling
www.nature.com/articles/s41...
Thank you Steffi and Veselin.

Thio-NHS esters are non-innocent protein acylating reagents - Nature Communications N-Hydroxysuccinimide (NHS)-ester derivatives are one of the most widely used acylating agents. In this work, the authors report that ring-opening reaction of the succinimide to afford N-succinamide de...

www.nature.com/articles/s41...

Open positions We are looking for Postdocs! If you are interested in the lab in general as a postdoc, please feel free to apply with an open application, including a letter of motivation and a CV …

We have several open postdoc positions! We do computational biology 🧬🖥️ and deep learning to understand the genomics of genome instability and (somatic) genome evolution in ageing and cancer. Interested? 👉🏻 more details: tu-dresden.de/cmcb/biotec/...

Open Call: Max Planck Director in Biological Artificial Intelligence Expressions of interest or nominations to lead research in the field of Biological Artificial Intelligence at MPI-CBG.

Here's a job at my institute that just opened up: Max Planck Director in Biological AI. This is an amazing opportunity -
www.mpi-cbg.de/news-outreac...

Welcome!!! And Congrats!!!

🥳 Thrilled to share that I am starting a new position as W3 Full Professor of Biochemistry at @tudresden.bsky.social. From Aug 2025, the Chemical Glycobiology Lab will continue our mission to generate Chemical Precision Tools for #glycotime in one the most beautiful places in Germany 😊

🔥 Job alert! We are looking for an enthusiastic PhD candidate in the new Chemical Glycobiology Lab at @tudresden.bsky.social! Master in Chem or similar, experience in organic chem including chemoenzymatic, and most importantly: enthusiasm!

Deadline 8th July:

www.verw.tu-dresden.de/StellAus/ste...