UNSW Single Molecule Science

We are so proud to share that our very own Dr Sami Al-Izzi has been awarded an ARC DECRA for his groundbreaking work in applying maths & theoretical physics to unlocking secrets of devel & mechanobiology. Sami has been supported by @r-g-morris.bsky.social & @emblaustralia.org. Congratulations! 👏👏👏

Come and work with us! 👇

Privileged to join the ranks of EMBL Australia’s partner laboratories steering committee, representing @singmolsci.bsky.social, the EMBL Aus node in Single Molecule Science. Lots of new developments around the corner for this wonderful Medical & Life Sciences community in Australia.

Well done to the team from Single Molecule Science who participated in the Science in the Swamp celebration of 2025 National Science Week at Centennial Park, Sydney. 'Microscopic Safari' was a fun journey over everything in the nano and micron scale on a sunny winter Sunday. ✨😎 🧪

Extensible Immunofluorescence (ExIF) accessibly generates high-plexity datasets by integrating standard 4-plex imaging data Nature Communications - Gunawan et al. propose an Extensible Immunofluorescence (ExIF) strategy that integrates distinct 4-plex image panels from routine fluorescence microscopy into multiplexed...

Our #AI #research @natcomms.nature.com uses #multiomics data integration concepts to fuse 4-channel imaging data into unlimitedly multiplexed image datasets via generative deep learning to interrogate complex cell biology, like #EMT. Multiplexing made easy! rdcu.be/emtBc @singmolsci.bsky.social

Fantastic to see this short film about A/Prof Lawrence Lee who is a Group Leader in UNSW Single Molecule Science and the founding CEO of the exciting startup, SWAN Genomics 🧬🔬

Hello #AcademicBsky hivemind! Is there anyone out here (preferably from Australia / nearby) who uses FIB or BE lithography at submicron resolution on materials like quartz, and might be interested in collaborating with us on a cool new project?

Happy to take recommendations. 🧪 🔬

A beautifully elegant study from Vaish and Leeba and team looking at mitochondrial volume regulation using cleverly designed and fabricated chambers to track fission yeast divisions over time

How is mitochondrial volume maintained across successive generations of dividing cells? In our new preprint, we show how fission yeast cells use mitochondrial activity to control division timing and maintain mitochondrial homeostasis! (1/n)

📖 www.biorxiv.org/content/10.1...

Group photo of eight colleagues representing the dept, standing in front of the conference mural

Some colleagues sitting around a dinner table

A conference speaker standing at a lectern podium

Arindam Ghosh being introduced to the symposium by Liz Hinde.

Aaaand that’s a wrap at Asia Pacific Microscopy Congress 2025 in sunny Brisbane, attended by a big team from Single Molecule Science. Lots of exciting new 🔬 tools and translation in biomedical investigations. @ijayas.bsky.social @arindam92.bsky.social

The light sensing robots, each with a different type of cellular motility and carrying a different coloured flag, lined up at the start line in a dark room. In front of them is a small LED light in the distance that they are looking to move towards. Above the light, is a projector screen with the text, “Immune Cell Robots on Patrol”.

Dr Daryan, Guiyuan, and Matteo explaining and demonstrating the robots to a group of high school students.

Dr Jesse standing next to the simulation of Killer T Cell sensing infected epithelial cells (on an art board next to him).

Upasana explaining to a group of kids and their families the difference between four models of 👌🏾 hands 3D printed at different resolutions in order to explain the importance of resolution in microscopy.

More photos of the activities put on show by the Molecular Medicine team.

A group photo of the Molecular Medicine (Single Molecule Sciences) team. In front, a table with some objects, including a miniature microscope. In the background, a large tv screen with vibrant images of cells and molecules.

A conversation between Upasana from Molecular Medicine and a little girl and her mum. Upasana is leaning over a table with a miniature microscope.

Some team members of Molecular Medicine standing in front of a colourful big tv screen and talking to some of the SciFest visitors

A father and daughter speaking with Dr Jon and pinning the superhero capes on the art board game of bacteria deployed to save the Great Barrier Reef.

We’ve had a single molecule festival here today at the @UNSW SciFest yesterday. Our corner of the exhibition featuring light sensing robots 🤖, reef cleaning super hero bacteria 🦸🏾‍♂️ , miniature microscopes, when killer T cells. A wonderful team effort and a busy evening for Team Molecular Medicine.

Final week for applications for up to 2 postdoc posts in advanced biomedical (super-resolution) microscopy with my team in Sydney, based at @singmolsci.bsky.social. The post is especially suited for ECRs interested in single molecule imaging, &/or image analysis. International applicants welcome 🧪

Artistic depiction of the HIV capsid disguised as a host chaperone protein

The #HIV capsid mimics host chaperones to gain access into the nucleus, solving a long-standing mystery – David Jacques' team published in Nature.
@singmolsci.bsky.social #UNSWSBMS
🔗 nature.com/articles/s41...
🎨: Jon Berengut

Pharmacologic hyperstabilisation of the HIV-1 capsid lattice induces capsid failure bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

🚨preprint @biorxivpreprint.bsky.social
We use #SingleMolecule🔬to see how a capsid-targeting antiviral (lenacapavir) hacks assembly of the HIV capsid, which normally protects the #HIV genome. Now also with real-time visualization of the drug breaking open the capsid. www.biorxiv.org/content/10.1...

We've still taking applications to join our team @singmolsci.bsky.social. Now closing 10Dec2023
🔗 external-careers.jobs.unsw.edu.au/cw/en/job/52...

Being able to work with a research & cultural leader like Izzy @ijayas.bsky.social is an opportunity you won’t want to miss.

Thanks for highlighting our (@polybiotique.bsky.social) report and its coverage by @dyanilewis.bsky.social, Izzy. As we mention in our report, fixing this will require clearly earmarked resources, and importantly, the will and strong commitment to equity from the leadership in Indian academia.

Differential labelling of human sub-cellular compartments with fluorescent dye esters and expansion ... Amine-reactive esters of aromatic fluorescent dyes are emerging as imaging probes for nondescript staining of cellular and tissue architectures. We characterised the staining patterns of 14 fluorescen...

Latest paper from our team on variations in cellular staining with 14 different fluorescent dye esters when combined with expansion microscopy. Strategic deployment of these dyes with expansion 🔬 can not only provide EM-like images, but also highlight different sets of cellular organelles. 🧪

Remembering the role of luck and privilege in academic achievement This week I woke up to the announcement by my alma mater — The University of Auckland — of its 2023 cohort of ’40 under 40’ that listed me…

A few things that I've needed to get off my chest for some time now. 🧪 🌋

Towards inclusive and sustainable scientific meetings

Ariel photo of UNSW's main campus located near close to beaches

🚨Join us at UNSW Sydney!
We're searching for a postdoc to join our team to investigate dynamics of host-pathogen interactions🦠.
#SingleMolecule #microscopy🔬
Apply by 26Nov2023. Please share 🔗https://external-careers.jobs.unsw.edu.au/cw/en/job/520570/post-doctoral-fellow-hostpathogen-biophysics