Gopinath Chattopadhyay

De-novo promoters emerge more readily from random DNA than from genomic DNA Promoters are DNA sequences that help to initiate transcription. Point mutations can create de-novo promoters, which can consequently transcribe inactive genes or create novel transcripts. We know lit...

Excited / nervous to share the “magnum opus” of my postdoc in Andreas Wagner’s lab!

"De-novo promoters emerge more readily from random DNA than from genomic DNA"

This project is the accumulation of 4 years of work, and lays the foundation for my future group. In short, we… (1/4)

Here we mapped ~250,000 variants of a classic regulatory element in E. coli. Even this tiny 9-bp sequence encodes a rugged, environment-sensitive fitness landscape.
It shows how gene regulation can constrain—or enable—evolution, depending on the context.

The fitness landscape of the E.coli lac operator is highly rugged in two different environments We know little about the fitness landscapes of bacterial operators, regulatory DNA elements that are crucial to regulate metabolic genes like those of the lac operon for lactose utilization. For examp...

🚨 New preprint from the Andreas Wagner lab
lab at University of Zurich, with Andrei Papkou:
🧬 "The fitness landscape of the E. coli lac operator is highly rugged in two environments"
🔗 biorxiv.org/content/10.1...
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