WashU Medicine Knight ADRC

What the Air You Breathe May Be Doing to Your Brain Studies increasingly find links between higher concentrations of certain pollutants and the prevalence of dementia.

What the Air You Breathe May Be Doing to Your Brain

Alzheimer’s disrupts circadian rhythms of plaque-clearing brain cells In a study published in Nature Neuroscience, researchers at Washington University School of Medicine in St. Louis showed in mice that Alzheimer's disease upended the daily activity patterns of hundreds of genes in cells that regulate key functions in the brain.

Alzheimer’s disrupts circadian rhythms of plaque-clearing brain cells

Issues in Aging: Silent Strokes and the Aging Brain This seminar is part of the monthly Issues in Aging series that highlights current research and perspectives on aging-relevant issues from experts in medicine, social work, psychology, law and more. This event will take place virtually via Zoom webinar. Please register to receive our unique link to attend.

Issues in Aging: Silent Strokes and the Aging Brain - October 27, 2025 at 12pm-1pm

He Was Expected to Get Alzheimer’s 25 Years Ago. Why Hasn’t He? Scientists are searching for the secret in Doug Whitney’s biology that has protected him from dementia, hoping it could lead to ways to treat or prevent Alzheimer’s for many other people.

He Was Expected to Get Alzheimer’s 25 Years Ago. Why Hasn’t He?

NEXT WEEK!

Join us for the 20th Annual Norman R. Seay Lecture entitled "Honoring Legacy. Accelerating Progress."

October 14, 2025, 4:00–5:00 PM CST
Hybrid Event. Registration Required.

More info & to register: knightadrc.wustl.edu...

#AlzheimersAwareness #ResearchMatters

A scientist at Washington University in St. Louis has received a grant from the Alzheimer’s Association to support his research investigating the electrochemistry of neurotoxic protein assemblies.

source.washu.edu/cha...

EVENT REMINDER

Join us for the 20th Annual Norman R. Seay Lecture entitled "Honoring Legacy. Accelerating Progress."

October 14, 2025, 4:00–5:00 PM CST
Hybrid Event. Registration Required.

More info & to register: knightadrc.wustl.edu...

#AlzheimersAwareness #ResearchMatters

What is the secret to healthy aging? Want to age well? Researchers in psychological and brain sciences are exploring what helps people live better and longer.

What is the secret to healthy aging?

Can Crosswords and Games Prevent Dementia? Experts say the answer is a puzzle.

Can Crosswords and Games Prevent Dementia?

Hormone Replacement Therapy Could Help Women Avoid Dementia—If It’s Taken at the Right Time Delaying HRT could do more harm than good, a new study shows.

Hormone Replacement Therapy Could Help Women Avoid Dementia—If It’s Taken at the Right Time

Issues in Aging : Bethany Goff, MSW, LCSW, MA, EverTrue, presents on the Guiding an Improved Dementia Experience (GUIDE) Model. As part of a monthly seminar hosted by the Harvey A. Friedman Center for Aging at The Brown School, Bethany Goff, MSW, LCSW, MA, EverTrue, presents on the Guiding an Improved Dementia Experience (GUIDE) Model. The GUIDE Model focuses on comprehensive, coordinated dementia care and aims to improve quality of life for people with dementia, reduce strain on their unpaid caregivers, and enable people with dementia to remain in their homes and communities. It will achieve these goals through Medicare payments for a comprehensive package of care coordination and care management, caregiver education and support, and respite services. It advances key goals of the National Plan to Address Alzheimer’s Disease, which was established through the bipartisan National Alzheimer’s Project Act (NAPA) and has, for over a decade, accelerated federal actions to optimize the quality of care for people with dementia and their caregivers while advancing research towards a cure. The GUIDE Model builds off of this extensive coordination within Health and Human Services and major input from various external stakeholders.

Issues in Aging : Bethany Goff, MSW, LCSW, MA, EverTrue, presents on the Guiding an Improved Dementia Experience (GUIDE) Model.

Treatment Options for Agitation in Alzheimer’s Disease A combination of FDA-approved medication and lifestyle considerations can help people with Alzheimer's disease and their caregivers manage episodes of agitation.

Treatment Options for Agitation in Alzheimer’s Disease

Join Us for the 20th Annual Norman R. Seay Lecture entitled "Honoring Legacy. Accelerating Progress."

October 14, 2025, 4:00–5:00 PM CST
Hybrid Event. Registration Required.

More info & to register: knightadrc.wustl.edu...

#AlzheimersAwareness #ResearchMatters

New computational tool sheds light on ‘wiggly’ proteins Researchers at Washington University School of Medicine led by Alex Holehouse have developed a novel method of predicting how certain hard-to-study proteins will behave, with potential implications for research and treatment of many diseases.

New computational tool sheds light on ‘wiggly’ proteins

Lenze named XPRIZE Healthspan semifinalist  Eric J. Lenze, MD, and his team at Washington University School of Medicine in St. Louis' Healthy Mind Lab are among 40 semifinalists in the XPRIZE Healthspan competition awarded $250,000 to study approaches to improve healthy aging.

Lenze named XPRIZE Healthspan semifinalist

People carrying two copies of ‘Alzheimer’s gene’ lowered risk by 35% via diet changes | CNN The award-winning Mediterranean diet helps prevent dementia, especially in people at highest genetic risk, according to a new study.

People carrying two copies of ‘Alzheimer’s gene’ lowered risk by 35% via diet changes | CNN

How Do ‘Super-Agers’ Stay Young? What 25 Years of Research Has Revealed. After 25 years of research on this notable group, here’s what stands out.

How Do ‘Super-Agers’ Stay Young? What 25 Years of Research Has Revealed. www.nytimes.com/2025...

Blood plasma reveals shared pathways in neurodegenerative diseases Washington University in St. Louis School of Medicine researchers identify biomarkers of Alzheimer’s, Parkinson’s and frontotemporal dementia from blood plasma, suggesting new therapeutic avenues.

Blood plasma reveals shared pathways in neurodegenerative diseases source.washu.edu/202...

FIRST ON CNN: Dramatic lifestyle changes can fight early-stage Alzheimer’s, study says. Here’s how | CNN Adopting intensive lifestyle changes can slow or stop progression of early-stage Alzheimer’s disease, according to a new study.

FIRST ON CNN: Dramatic lifestyle changes can fight early-stage Alzheimer’s, study says. Here’s how | CNN www.cnn.com/2025/07/...

You can slow cognitive decline as you age with lifestyle changes, large study finds | CNN Lifestyle interventions can slow cognitive decline in your 60s and 70s, according to a large randomized controlled trial. Here’s how.

You can slow cognitive decline as you age with lifestyle changes, large study finds | CNN www.cnn.com/2025/07/...

7 Caregiver Tips for Calming Alzheimer's Agitation As a caregiver of someone with Alzheimer’s, you know that agitation and aggressive behavior can happen from time to time.

7 Caregiver Tips for Calming Alzheimer's Agitation healthguides.cnn.com...

4 Tips for Coping with Mild Cognitive Impairment Practical tips can help you manage mild cognitive changes and boost brain health. Small adjustments to your daily routine can help you stay mentally active and engaged.

4 Tips for Coping with Mild Cognitive Impairment healthguides.cnn.com...

Three Siblings, One Fatal Gene: A Family’s Fight Against Early-Onset Alzheimer’s Among members of the Richardson family who carry a mutation in the PSEN1 gene, the average age when symptoms start is 39.

Three Siblings, One Fatal Gene: A Family’s Fight Against Early-Onset Alzheimer’s www.wsj.com/health/p...

What to Do When a Loved One is Diagnosed With Dementia Families and experts share their best advice for navigating and coping.

What to Do When a Loved One is Diagnosed With Dementia www.nytimes.com/2025...

How rogue jumping genes can spur Alzheimer’s, ALS Our genomes are peppered with DNA segments called retrotransposons that can move from place to place. When unleashed, some can kill nerves and promote inflammation — a discovery that may inspire treatments for neurodegeneration.

How rogue jumping genes can spur Alzheimer’s, ALS knowablemagazine.org...

Sleep aid blocks neurodegeneration in mice A new study by Washington University in St. Louis School of Medicine researchers suggests that lemborexant and sleep aids that work the same way could help treat or prevent damage caused by harmful buildup of the protein tau in multiple neurodegenerative diseases, including Alzheimer’s.

Sleep aid blocks neurodegeneration in mice source.washu.edu/202...

Does the MIND Diet Prevent Dementia? (Published 2023) Healthy eating might help protect your brain, experts say, but other factors play in as well.

Does the MIND Diet Prevent Dementia? (Published 2023) www.nytimes.com/2023...

Alzheimer's hope: Sleep aid blocks up to 40% more harmful tau deposits A readily available sleep aid has been shown to have a surprising side effect on brain health, seemingly protecting the organ from the buildup of the tau protein – a key biomarker in the development of neurodegenerative diseases including Alzheimer's.

Alzheimer's hope: Sleep aid blocks up to 40% more harmful tau deposits newatlas.com/brain/a...

Drug to slow Alzheimer’s well tolerated outside of clinical trial setting In a recent study, researchers at Washington University School of Medicine in St. Louis found adverse events were rare and manageable among patients with very mild or mild Alzheimer’s disease who received infusions of a next-generation Alzheimer's medication.

Drug to slow Alzheimer’s well tolerated outside of clinical trial setting source.washu.edu/202...

FDA greenlights first blood test to help diagnose Alzheimer’s disease in the US | CNN The US Food and Drug Administration has given marketing clearance to a blood test to help diagnose Alzheimer’s disease, making the test the first to get signoff to aid in the early detection of the disease in the United States.

FDA greenlights first blood test to help diagnose Alzheimer’s disease in the US | CNN www.cnn.com/2025/05/...