Justin J. Taylor, PhD

A SERENDIPITOUS PATH TO DISCOVERING A POTENT MONOCLONAL ANTIBODY (mAb) FOR THE TREATMENT OF HUMAN METAPNEUMOVIRUS (HMPV) INFECTIONS Harris et al. discovered a rare but potent human mAb against HMPV that has a unique neutralizing mechanism. The antibody 4F11 has a high barrier against the development of resistance, has therapeuti...

Check out our new paper @fredhutch.org just published in
@natureportfolio.nature.com
Communications on a rare and unique antibody that could be used to treat a common respiratory virus called HMPV. And for the "untold story" behind the paper, here's more at go.nature.com/4bLBmim

Thanks to the Beirne Carter Foundation’s generosity, we will soon launch the Human ImmunoPhenotyping Initiative! Founded by Beirne Carter (left) & now led by Rossie Hutcheson (right), the BCF continues to advance our mission to improve patient care through immunology research.

🎉🔬 Congrats to Haroldo Rodriguez on successfully defending his PhD dissertation, “Characterizing the Role of Tumor-Specific B Cells in Merkel Cell Carcinoma Disease Control!” @justintaylorlab.bsky.social

🔗 mc3institute.uw.edu/news/haroldo-rodriguez-successfully-defends-phd-dissertation

A searchable database of publications using fluorescent probes and flow cytometry to study antigen-specific B cells The study of antigen-specific B cells has resulted in important advances in all fields of immunology, the development of experimentally and/or clinically useful antibodies, and as a starting point for...

Functional link here: www.biorxiv.org/cgi/content/...

All with numerous publications: @jimmunol.bsky.social, @jem.org, @cp-immunity.bsky.social, @cp-cellreports.bsky.social, @sciimmunology.bsky.social, @natimmunol.nature.com, @nature.com, @natcomms.nature.com, @cellpress.bsky.social, @pnas.org, @science.org, @eurjimmunol.bsky.social & @jci.org (4/4)

homer simpson from the simpsons is standing in a doorway with his arms crossed and the words `` thoughts ? '' Alt: homer simpson from the simpsons is standing in a doorway with his arms crossed and the words `` thoughts ? ''

Any thoughts on where to submit the overview? Papers in the database are in over 100 different journals, with the ones next in the thread being the most frequently found (3/4)

The database includes work studying hundreds of unique antigens from hundreds of labs. Many thanks to my lab, Scott Chappell from @uvaimmunology.bsky.social , and @koenigjfe.bsky.social for helping build the database. www.immunology.virginia.edu/Taylor/Bcell... (2/4)

Bubble Chart displaying the different types of antigens targeted by B cells in the papers in the database so far. Antigens are grouped into the the viruses, bacteria, parasites, plants, animals, or other sources they come from. And the bubble sizes are scaled to represent how frequently those antigens have been used

A few years ago, my lab started a list of papers analyzing antigen-specific #Bcells w/ fluorescent probes via #flowcytometry. We are now releasing this list of 700+ papers as a searchable database on my lab website with a short overview. www.biorxiv.org/content/10.1...

We are currently in the process of recruiting a technician. 🥼🐭🔬

If you know anyone with enthusiasm to learn new skills and stamina to hear me go on and on about IFNs, please have them reach out to me for more details!

Jinyi Tang, PhD, received an NIHK99/R00 grant! The award was issued for Jinyi's work developing mucosal vaccines, which he and the @jie-immunology.bsky.social lab have shown to offer additional protection against COVID-19.

Read more: immunology.virginia.edu/jtang_k99/

Perspective @cp-immunity.bsky.social A roadmap for defining “extrafollicular” B cell responses
www.cell.com/immunity/ful... @stephanieeisen.bsky.social @vinuesalab.bsky.social et al

CIC Resident Member @immunegirl.bsky.social received an award from the Michael Pascucci Cancer Association to fund her work in engineering T cells against ovarian cancers. Congratulations!

@jie-immunology.bsky.social lab postdoc Jinyi Tang, PhD, studies immune cell behavior in the lungs after viral infections and mucosal vaccine development. He joined the CIC from the Mayo Clinic in 2021 and recently received a prestigious NIH K99 award! He's also a fan of movies, games, and hiking.

Lab Manager I The Subramanian Lab is seeking a highly motivated and capable Lab Manager I to oversee vivarium operations, manage general lab maintenance and procurement, and contribute directly to research efforts ...

We're hiring! Our lab @ISB is looking for a full-time Research Associate to manage our mouse colony 🐭, run experiments in a Type 1 diabetes model, and help keep the lab running smoothly.
Ideal for someone aiming for grad school or further scientific training. isbscience.bamboohr.com/careers/56

Incredibly honored to announce I've received an R37 MERIT award to continue our studies on gonococcal-neutrophil interactions. Thank you to the many mentors, colleagues, collaborators, and most importantly, lab members who have contributed to this work!

With deep gratitude, we thank Dr. Marc Jenkins for his decades of leadership, mentorship, and dedication to the Center for Immunology. The foundation he built will guide and inspire us for years to come.

🎉 Thrilled to announce the #NCI has renewed a $14.3M project grant — “Immunobiology & Immune Therapy for Merkel Cell Carcinoma” — led by Dr. Paul Nghiem!

🔗 tinyurl.com/y62adf2f

Funding will support 60 scientists at:
@fredhutch.bsky.social
@uofwa.bsky.social
@uofmichigan.bsky.social
Uni of Virginia

Make that 19 out of 19 cases. Whoops!

All 37 authors from our labs & @mc3-institute.bsky.social were critical for this work, too many to mention here! The project was ultimately led by UW M3D grad student Haroldo Rodriguez, who is co-mentored by Paul and has been visiting @uvaimmunology.bsky.social since the Taylor lab relocated (5/5)

This project was started 8 years ago when I was contacted by Paul Nghiem and David Koelle at @uwmedicine.bsky.social and Denise Galloway @fredhutch.bsky.social, who had been studying oncoprotein-specific T cell and antibody responses. And we recruited Josh Veatch's lab along the way (4/5)

Overall germinal center and Tfh cell responses did associate with outcome. And human B cells engineered to be specific for oncoprotein potently stimulate human CD4+ T cells specific engineered to express an oncoprotein-specific TCR cloned from a patient sample (3/5)

While our tumor sample cohort is small, we could accurately predict disease outcome in 14 of 14 cases by analyzing oncoprotein-specific B cells. In contrast, when we analyzed the much larger populations of B cells in the same samples, this predictive ability is diminished (2/5).

Excited to share this preprint of our work studying B cells specific for the oncoprotein driving most cases of Merkel cell carcinoma. While oncoprotein-specific B cells are rare in tumor samples, when we detect robust responses in tumor samples patients do not experience disease progression. (1/5)

STAGGERING: This new study of 133 countries is the first to estimate the impact of all USAID’s work. In 2 decades, it has saved *92M* lives. Current cuts, if not reversed, are forecast to cost up to *14M* lives thru 2030. www.thelancet.com/journals/lan...

Trump cuts subscriptions to Springer Nature journals Other publishers appear unscathed in recent actions

Your Saturday dose of anti-science bullshittery...

www.science.org/content/arti...

1/n

The Trump administration has privately demanded that the University of Virginia oust its president to help resolve a Justice Department investigation into the school's diversity, equity and inclusion efforts, according to three people briefed on the matter.

I feel like this isn’t getting enough attention…because this is CRAZY????

www.nytimes.com/2025/06/27/u... University of Virginia President Resigns Under Pressure From Trump Administration - The New York Times

University of Virginia President Resigns Under Pressure From Trump Administration

Sad to see the Trump admin force resignation of UVA President Ryan. No due process, just hurried political attacks to undermine values of free expression and knowledge on which Thomas Jefferson founded UVA.
www.nytimes.com/2025/06/27/u...

University of Virginia President Resigns Under Pressure From Trump Administration

Wow. Just wow.

University of Virginia President Resigns Under Pressure From Trump Administration www.nytimes.com/2025/06/27/u...

The #SIS2025 swag bags are ready -- are you? We're looking forward to hosting the Southeastern Immunology Symposium at UVA in 3 days!

Open Letter in Support of Science — STAND UP FOR SCIENCE

Proud to sign on this this open letter.

Join me....

www.standupforscience.net/open-letter-...