Conor Lee-Smith

Could man make a decorative yard skeleton to tall He could not wrangle it?

Seems like health care would be a pretty important part of "quality of life" especially for people at retirement age

Never a bad time to rewatch this banger from @hbomberguy.bsky.social and get really angry all over again

Actually, the "Bitcoin buried in Newport landfill" is pretty whimsical upon second reflection. Man drives himself to madness concocting plan to dig through a mountain of garbage.

No missing treasures from the last 50 years with an existence status of "Legend" is really a sign that we're in dire times. Where's the whimsy?

Seems bad!

WHAT WOULD POSSIBLY BE THE MECHANISM THIS IS SUCH CLOWN SHIT

Updated Zotero without realizing the new version is no longer compatible with ZotFile and now my whole paper organization system is borked and I just don't have the will to deal with that right now

I'm a single issue voter now, my issue: revenge

How do resident Golgi proteins recycle during cisternal maturation? Nice preprint from Adam Krahn in the Glick lab shows different classes of intra-Golgi vesicles in yeast: two COPI-dependent (early and mid) and one late clathrin/AP-1/Ent5 pathway.
www.biorxiv.org/content/10.1...

COPI-dependent intra-Golgi recycling at an intermediate stageof cisternal maturation https://www.biorxiv.org/content/10.1101/2025.09.20.677526v1

Steven

A little opera in the park/warzone

you'd think the governor of illinois basically going "we're being invaded by an authoritarian" would be something you'd see real easy on the front page of most everything an hour later

Pritzker: "I refuse to pretend that any of this is normal ... I refuse to fall into the pundit trap that demands we sacrifice vital constitutional rights if it's being done in the fake guise of fighting crime."

jfc

So it's an LLM which has to be trained on the wider internet to be at all useful, which means it has been trained on facts which are at odds with the entire platform of the Republican Party, right?

Just saw a video of someone in a lab somewhere that uses an InstantPot to autoclave their tips and I am shook

Once again, something broke in the building my lab is in and we’ve been asked to evacuate out of an abundance of caution. Good thing they’re putting a BSL3 tuberculosis lab in there!

I can't keep up with all the bad news. I think some bad stuff got removed, but there is just so much awful that its hard to keep track of.

On the bright side, the alarm or monitor somewhere in our apartment building appears to be battery powered and is still chirping away

ComEd says you get higher prices for electricity because of AI and also you actually don’t get any of the electricity

Hmm, not the best time to entirely lose power

Really messed up that I get super productive at like 2am

Hey @durbin.senate.gov and @duckworth.senate.gov, y'all and your colleagues going to continue to try to work with Republicans like nothing is wrong?

We need to build some real social stigma around being afraid of cities. You don't have to like them or live there, but a politics built this strongly around watching TV and going "ewww" is embarrassing, and people should be embarrassed by it. It's like "fear of werewolves" being your top issue.

God bless Snail Thai

The woman who works at the Thai place I would go to all the time right next to the apartment I used to live in still recognizes me even though it’s been 2 years since I lived there 🥲