Wen Ding

Kidney disease affects 1 in 10 of the UK population and has largely been overlooked in the UK 10 Year Health Plan. Please sign this petition by Thursday 9th October to emphasise the importance of a national strategy for kidney disease. www.ukkidney.org/prime-minist...

Great talk about the Hidden initiative from Kate Bramham and detecting CKD in the community in London. Absolutely inspirational @kidneyresearchuk.org

Having a fantastic time listening to all the progress in kidney research in the UK @kidneyresearchuk.org driving discoveries. Fantastic talk @willkidney.bsky.social about how large well designed trials have changed our practice in nephrology

Your kidneys are working hard for you every day, every hour. Return the favor with these small habits that lead to lifelong health. 💬 Which of these do you already do? Which one could you start this week? #KidneyFacts #HealthyKidneys #NephrologyTips #BIGKiDsStudy #KidneyHealthAwareness #sampsonlab

FDA Accepts, Grants Priority Review to Sibeprenlimab BLA for IgA Nephropathy With the priority review acceptance of the Biologics License Application, the FDA has assigned a PDUFA target action date of November 28, 2025.

Sibeprenlimab inches closer to approval

www.hcplive.com/view/fda-acc... feat @brendonneuen.bsky.social

Phase 3 RCT next week at #ERA25 (& some journal?)

Sparsentan for FSGS?? It's alive....
ir.travere.com/press-releas...

Every 10 seconds vaccination saves a life. Immunization for all is Humanly Possible

It’s #WorldImmunizationWeek

Vaccines have saved 154 million lives in the last 50 years. That’s 6 lives every minute.

A reminder of what is #HumanlyPossible. Science saves lives.

#VaccinesWork
bit.ly/wiw2025

Reprogramming site-specific retrotransposon activity to new DNA sites - Nature A study of retrotransposon activity repurposes a retroelement called R2Tocc to create a programmable system called STITCHR that enables diverse genome edits including efficient, scarless large pa...

So excited to share our new paper out today in @nature.com. We repurposed R2 retrotransposons to create STITCHR, a tool that can make virtually any kind of edit in mammalian genomes including the scarless multi-kilobase scale insertions 🧵

www.nature.com/articles/s41...

Interesting!

Wow! This IS dedication

Why do you have ultrasound gel in the car? 🤔

Design of study using sequencing of B and T cell receptor and A.I. models to unravel information about infections and autoimmune conditions

Other than the brain, our immune system is the most complex part of the human body. For the first time, sequencing receptors of B and T cells, along w/ generative A.I., enabled diagnosis of medical conditions such as lupus. That's just for starters. erictopol.substack.com/p/the-first-...

What an exciting time to be a nephrologist. Yet another really promising therapy for IgA. Decreases proteinuria significantly, likely will be spoilt for choice soon but how will be choose the right meds for the right patient?

Not apologising for posting this paper twice as really excited about ProtGPS. Logical next step in protein modelling after the success of alphafold2. Not only will help predict pathogenicity of genetic variants but can incorporate elements for subcellular compartmentalisation in gene therapy design

Protein codes promote selective subcellular compartmentalization Cells have evolved mechanisms to distribute ~10 billion protein molecules to subcellular compartments where diverse proteins involved in shared functions must assemble. Here, we demonstrate that prote...

🧬🧪Protein codes promote selective subcellular compartmentalization | Science www.science.org/doi/10.1126/...
Henry Kilgore @itamarchinn.bsky.social @pgmikhael.bsky.social Ilan Mitnikov, et al. @aihealthmit.bsky.social @whiteheadinstitute.bsky.social @mitofficial.bsky.social

Gene editing technology began by people studying salt marshes. Ozempic began by folks studying the venom of Gila Monsters. Support for basic science has empowered us to understand our world. Tethering it to applications health has transformed and saved countless lives.

No idea how the academic world would cope without pubmed

Fascinating read: history of ISKDC. Our current management of nephrotic syndrome not very different from this first nephrotic syndrome RCT. (Other than AZA which was shown not to be useful in iNS)

media.springernature.com/full/springe...

Adolescent Blood Pressure and Early Age Stroke Underdiagnosis of relevant risk factors has contributed to the increasing stroke incidence in young adults. Blood pressure cut-off values for adolescents are neither sex specific nor based on cardi...

Why we need to start monitoring #BP before adulthood for #cardiovascular #prevention #CvPrev

Adolescent #BloodPressure & Early Age #Stroke in @nejm.org Evidence

evidence.nejm.org/doi/full/10....

As a result sub-specialty recruitment is generally good!

I hadn’t realised this was the case in the US, training length the same for Paediatric specialities versus general in the UK, and pay is the same on completion

Critical Illness in an Adolescent with Influenza A(H5N1) Virus Infection | NEJM Influenza A(H5N1) viruses are an emerging zoonotic threat and have spread widely throughout birds in North America. Recently, influenza A(H5N1) infection led to serious illness in a teenager in Canada.

This 13-year-old received 3 antivirals and plasma exchange for #H5N1. In over a decade as an ID doctor, I've never used such measures for #Influenza— not even during H1N1.

#H5N1 is alarming; we must boost surveillance, testing, prevention, and education to control it.
www.nejm.org/doi/full/10....

Chronic Kidney Disease is rising in prevalence--I have signed this petition for the World Health Organisation to recognise kidney health as a priority, do consider signing to prioritise preventing premature death from kidney disease
#nephsky #medsky #pedsky

😱
Have never dared to use any of these but surely you would check through carefully if you did! Worrying that these passed peer review, editorial boards etc 🤔

#PedSky appreciation post: Dr. Weyand’s posts are why I now check ferritin/CRP for every anemia screen (w CBC + retic)! I’ve caught so many w single digit ferritin levels even if Hgb is “normal” 😱 It’s also an issue in “picky eaters” even if they’re not menstruating

A great keynote by Moin Saleem from Bristol UK, followed by a terrific discussion @rfsgsinitiative.bsky.social @genetickidneydoc.bsky.social @opeyemiolabisi.bsky.social @gbadegesinlab.bsky.social

Some papers are very difficult to read but that doesn’t necessarily mean they're deeper than other papers. Authors must work very hard to make their story easy to read and understand by others. Or as Stephen King says: "the shorter the book, the less bullshit".

Hello and thank you to all who have followed us so far! Look out for some of our posts coming to #Bluesky soon 😍

In the meantime, if you are living with #ChronicKidneyDisease and need support from us, please visit our website: kidneycareuk.org/get-support/

#KidneyCareUK #CKD #CKDSupport #Dialysis

Women are under-represented at senior levels in #academia globally, & across all #science 🧪 disciplines, as shown by these "scissor-shaped curves" ✂️

So how can we ever achieve #gender #equality?

We discuss various strategies in this #Cell Commentary

#WomeninSTEM

www.cell.com/cell/fulltex...
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🤔 Why doesn't an elevated BUN lead to extreme thirst? If increased serum osmolarity compels us to seek water, uremia should be a significant driver of this craving.

And yet, it isn't.

Let's examine why.