RNA Therapeutics Institute

PhD candidate Emily Sholi receives grant to study pathogens’ impact on ribosomes PhD candidate Emily Sholi has received an NIH fellowship to further her ribosome research, investigating how pathogens inhibit host ribosomes.

PhD candidate Emily Sholi has received a prestigious NIH award to further her ribosome research, using cryo-EM methods to understand how pathogens such as pneumonia-causing Pseudomonas aeruginosa inhibit host ribosomes: direc.to/oePr

#StudentSpotlight #RNA @rti-umasschan.bsky.social

Legislative Action Center FASEB partnerships & outreach: Legislative Action Center. Engage policymakers and communities; access the Legislative Action Center and resources.

Join Our Day of Action to Protect Medical Research! Use FASEB's Legislative Action Center to call or email your members of Congress & urge them to support at least $47.2 billion for NIH in the final fiscal year 2026 budget. #UnitedForCures #CuresCantWait

Structural mechanism of mRNA decoding by mammalian GTPase GTPBP1 - PubMed GTP-binding protein 1 (GTPBP1) is a widespread translational GTPase closely related to elongation factor eEF1A. The loss of GTPBP1 leads to neurodevelopmental and neurodegenerative disorders in animals....

Hot off the press from the RTI: Structural mechanism of mRNA decoding by mammalian GTPase GTPBP1
buff.ly/UCQRlnd #RNA #RNATherapeutics

Legislative Action Center FASEB partnerships & outreach: Legislative Action Center. Engage policymakers and communities; access the Legislative Action Center and resources.

Join Our Day of Action to Protect Medical Research!! Congress needs to hear from you today. Use FASEB's Legislative Action Center to call or email your members of Congress & urge them to support at least $47.2 billion for NIH in the final fiscal year 2026 budget.

SPARK: in silico simulations for benchmarking nascent RNA sequencing experiments - PubMed Nascent RNA sequencing offers profound insights into transcriptional dynamics, yet there are substantial challenges to analyzing these data. The development of proper computational tools necessitates...

Hot off the press from the RTI: <em>SPARK</em>: <em>in silico</em> simulations for benchmarking nascent RNA sequencing experiments
buff.ly/3iWYgom #RNA #RNATherapeutics

Control of gene output by intron RNA structure - PubMed Intron removal through pre-mRNA splicing is a central step in gene expression across Eukarya. The process initiates with the recognition of intronic sequence elements (splice sites) by highly conserved...

Hot off the press from the RTI: Control of gene output by intron RNA structure
buff.ly/y7DvYmI #RNA #RNATherapeutics

KRAS Withdrawal in Cholangiocarcinoma Leads to Immune Infiltration and Tumor Regression - PubMed Cholangiocarcinoma (CCA) is a liver cancer subtype with poor survival rates. KRAS mutations are found in 15-40% of CCA, representing a new potential treatment target. Whether KRAS inhibition leads to...

Hot off the press from the RTI: KRAS Withdrawal in Cholangiocarcinoma Leads to Immune Infiltration and Tumor Regression
buff.ly/t7dhgRd #RNA #RNATherapeutics

TODAY is the deadline for graduate applications to the Morningside Graduate School of Biomedical Sciences and the new RNA Therapeutics & Biology program here at UMass Chan: www.umassmed.edu/gsbs/academi...

PhD student in the lab at UMass Chan Medical School

Monday, Dec. 1, is the deadline to apply to the Basic Biomedical Sciences Umbrella Pathway, a PhD program at UMass Chan Medical School: direc.to/oaxc

Students rotate through up to three research labs their first year prior to joining a specific research group and program.

#PhD #PhDSky

Dimeric gold nanoparticles enable multiplexed labeling in cryoelectron tomography - PubMed Cryoelectron tomography (cryo-ET) enables three-dimensional visualization of molecular structures within tissue and intact cells, providing a powerful tool for studying the spatial organization of biological...

Hot off the press from the RTI: Dimeric gold nanoparticles enable multiplexed labeling in cryoelectron tomography
buff.ly/4mq5ii3 #RNA #RNATherapeutics

From nematode to Nobel: How community-shared resources fueled the rise of Caenorhabditis elegans as a research organism - PubMed Experimental organisms such as the nematode <i>Caenorhabditis elegans</i> are fundamental to biological discovery. The success of <i>C. elegans</i> research has been greatly enabled by infrastructure...

Hot off the press from the RTI: From nematode to Nobel: How community-shared resources fueled the rise of <em>Caenorhabditis elegans</em> as a research organism
buff.ly/sVBP2OK #RNA #RNATherapeutics

HAPPENING TODAY AT 5:00PM ET! Sign up for the Basic Biomedical Sciences Umbrella Pathway Admissions Workshop on Tues, Nov 18, 2025: direc.to/nA7S

Attend our admissions workshop to get your questions answered ahead of the Dec 1, 2025 deadline for graduate applications.

We are so excited for inaugural Yongliang Liao Distinguished Lecture, given by Dr. Rachel Green, Johns Hopkins University on ZAK activation at the colliding ribosome! We are grateful for Dr. Amy Liao and her family for making this lecture possible!

Biomedical Sciences PhD | UMass Chan Medical School Advance the treatment and prevention of disease by earning your Biomedical Sciences PhD at the UMass Chan Medical School. Learn more.

Join a collaborative home of Nobel Prize-winning RNA research! The Morningside Graduate School of Biomedical Sciences is accepting applications for the new RNA Therapeutics & Biology Track in the Biomedical Sciences PhD program: direc.to/nEHU
#PhDChat #Gradschool #PhDSky

Suppression of Huntington's Disease Somatic Instability by Transcriptional Repression and Direct CAG Repeat Binding - PubMed Huntington's disease arises from a CAG expansion in the huntingtin gene beyond a critical threshold. Current therapeutics primarily aim to reduce toxicity by lowering levels of mutant HTT mRNA and protein....

Hot off the press from the RTI: Suppression of Huntington's Disease Somatic Instability by Transcriptional Repression and Direct CAG Repeat Binding
buff.ly/KZpiqXh #RNA #RNATherapeutics

At UMass Chan, where Nobel Laureates pioneered small RNA discoveries, we empower the next RNA GIANTS

OPEN FOR GRAD APPLICATIONS!! The NEW RNA Therapeutics & Biology Program in the Basic Biomedical Sciences PhD program develops leaders. Register for the workshop to get qs answered ahead of Dec 1, 2025 app deadline.
Admission Workshop Tues, Nov 18, 2025: direc.to/nA7S

UMass Chan Medical School scientists to assess gene editing technologies for treating frontotemporal dementia UMass Chan scientists have received funding to explore gene editing technologies for treating frontotemporal dementia.

RTI @UMassChan scientists have received a $6M+ grant to evaluate gene editing technologies for treating frontotemporal dementia: direc.to/nE19
#FTD #RNATx
@eriksontheimer.bsky.social
@umasschan.bsky.social
@jwattsgroup.bsky.social

TDP-43-dependent mis-splicing of KCNQ2 triggers intrinsic neuronal hyperexcitability in ALS/FTD - PubMed Motor neuron hyperexcitability is a broadly observed yet poorly understood feature of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Nuclear depletion and cytoplasmic aggregation...

Hot off the press from the RTI: TDP-43-dependent mis-splicing of KCNQ2 triggers intrinsic neuronal hyperexcitability in ALS/FTD
buff.ly/X23QYQI #RNA #RNATherapeutics

Phage SSB detection by retron Eco8 msDNA unleashes nuclease-mediated immunity - PubMed Retrons are antiphage defense systems that synthesize multicopy single-stranded DNA (msDNA) and are being adapted for genome engineering. The Escherichia coli retron Eco8 system comprises a reverse transcriptase...

Hot off the press from the RTI: Phage SSB detection by retron Eco8 msDNA unleashes nuclease-mediated immunity
buff.ly/HXnSgjd #RNA #RNATherapeutics

Structural mechanism of mRNA decoding by mammalian GTPase GTPBP1 - PubMed GTP-binding protein 1 (GTPBP1) is a widespread translational GTPase closely related to elongation factor eEF1A. The loss of GTPBP1 leads to errors in neuronal development in animals and is associated...

Hot off the press from the RTI: Structural mechanism of mRNA decoding by mammalian GTPase GTPBP1
buff.ly/oYbdavv #RNA #RNATherapeutics

mRNA initiation and termination are spatially coordinated - PubMed Transcriptional initiation and termination decisions drive messenger RNA (mRNA) isoform diversity but the relationship between them remains poorly understood. By systematically profiling joint usage of...

Hot off the press from the RTI: mRNA initiation and termination are spatially coordinated
buff.ly/vwSuPWC #RNA #RNATherapeutics

Hot off the press from the @korostelevlab.bsky.social Structural mechanism of mRNA decoding by mammalian GTPase GTPBP1

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Defining the roles of the Integrator, NEXT, and nuclear exosome complexes in Drosophila oogenesis - PubMed Nuclear RNA homeostasis depends on the balance of transcription, RNA processing, degradation, and transport between the nucleus and cytoplasm. RNA degradation directed by the Integrator, nuclear exosome...

Hot off the press from the RTI: Defining the roles of the Integrator, NEXT, and nuclear exosome complexes in Drosophila oogenesis
buff.ly/cWIXcBu #RNA #RNATherapeutics

Cryopreservation of siRNA-Treated Cells Is Feasible - PubMed Cryopreservation is a routine step in the manufacturing process of adoptive cell therapies (ACT), providing critical logistic flexibility. RNA interference (RNAi)-based therapies are increasingly being...

Hot off the press from the RTI: Cryopreservation of siRNA-Treated Cells Is Feasible
buff.ly/BWdy50S #RNA #RNATherapeutics

New insights into the role of IFN-α/β and TLR7/8/9 in cancer immunotherapy and systemic autoimmunity - PubMed The role of type I interferon (IFN) in mediating tumor immunosurveillance, in situ vaccination, and response to other cancer immunotherapies is well established. The biologic and species-specific differences...

Hot off the press from the RTI: New insights into the role of IFN-α/β and TLR7/8/9 in cancer immunotherapy and systemic autoimmunity
buff.ly/SuU8jSW #RNA #RNATherapeutics

UMass Chan Medical School licenses exNA oligonucleotide technology to Hongene Biotech Corporation UMass Chan Medical licenses exNA oligonucleotide technology to Hongene Biotech Corporation

UMass Chan licenses exNA oligonucleotide technology to Hongene Biotech Corporation: direc.to/nu79

By making exNA phosphoramidites and oligonucleotides available to researchers, Hongene hopes to advance more stable, tissue-specific RNA therapeutics. ‪

#exNA #RNA @rti-umasschan.bsky.social

A single amino acid variant in the variable region I of AAV capsid confers liver detargeting - PubMed AAV capsid serotypes isolated from nature have been widely used in gene delivery and gene therapy. Recently, more than 1,000 distinct AAV capsids were identified from human clinical samples by high-throughput,...

Hot off the press from the RTI: A single amino acid variant in the variable region I of AAV capsid confers liver detargeting
buff.ly/nmjkDIT #RNA #RNATherapeutics

Mutant huntingtin exon 1 protein detected in mouse brain with neoepitope antibody: effects of CAG repeat expansion, MutS Homolog 3 silencing and aggregation - PubMed <span><i>HTT1a</i> was identified in human and mouse Huntington's disease brain as the pathogenic exon 1 mRNA generated from aberrant splicing between exon 1 and 2 of <i>HTT</i> that contributes to aggregate...

Hot off the press from the RTI: Mutant huntingtin exon 1 protein detected in mouse brain with neoepitope antibody: effects of CAG repeat expansion, MutS Homolog 3 silencing and aggregation
buff.ly/oMspoFO #RNA #RNATherapeutics

It's back to school time in the RTI!!! Come join the Xue Lab for a Brainstorm “Classroom” Challenge with snacks and cake to celebrate another great school year! TODAY at 4pm in the 4th floor lobby!

A Compact Base Editor Rescues AATD-associated Liver and Lung Disease in Mouse Models Alpha-1 antitrypsin deficiency (AATD) is commonly caused by a G-to-A mutation in the SERPINA1 gene (the PiZ mutation). The mutant PiZ AAT protein is s…

ICYMI: Newest article from the Xue, Flotte, & Sontheimer labs: A Compact Base Editor Rescues AATD-associated Liver and Lung Disease in Mouse Models
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