Greg Atkinson

Nice!

I did not have to click on this to know what is would refer to the Hazda in the first paragraph, and I was not disappointed. The research this is based on, imo, asks an ill-posed question that has little salience for individuals.

Hats off to the authors for studying 2 cycles which enabled them to conclude no consistency in response (even without deriving person x treatment interaction). Always be suspicious of waterfall plots for showing "responders" in a "single" trial. More information here: osf.io/preprints/os...

Waterfall plots can be drawn to show individual differences in FMD% change between phases. Look at Figure (a) for cycle 1. Differences in response are indicated but look at Figure (b) for cycle 2 - a completely different picture. There's no consistency at all between the 2 cycles (Figure c).

This is a very interesting study comparing physiological variables between two phases of the menstrual cycle across two whole cycles. The design resembles a replicate crossover trial which enables proper study of individual responses. physoc.onlinelibrary.wiley.com/doi/10.1113/...

Every Scientific Empire Comes to an End America’s run as the premiere techno-superpower may be over.

For who still thinks this can’t happen here… it’s already happening.
www.theatlantic.com/science/arch...

To Infinity and Beyond
My talk from ICPM 2025 in Amsterdam earlier this year

icpm2025.com/wp-content/u...

Let’s kick off another issue with the assessment of fuelling strategies used during extended simulated soccer match play ⚽️

Fischer et al. (2025) compared glucose:fructose to glucose mixtures in semi-professional soccer players🥤

🔗 doi.org/10.1123/ijsn...

A brief guide to statistical analysis of grouped data in preclinical research Nature Metabolism - Clustering and nesting (C&N) arise in many preclinical studies, such as when animals are group-housed or share litters, or in cell culture. Ignoring C&N...

A brief guide to statistical analysis of grouped data in preclinical research rdcu.be/er3HG

A replicate crossover trial on the interindividual variability of sleep indices in response to acute exercise undertaken by healthy men AbstractStudy Objectives. Using the necessary replicate-crossover design, we investigated whether there is interindividual variability in home-assessed sle

The variable was from the replicate crossover by Yang et al. (2025). academic.oup.com/sleep/articl... We (well - @lorenzololli.bsky.social !!) hope to complete full analyses of all relevant variables in a few months. Stay tuned 🙂

This variable was measured 5 times within each period. There's a person by time interaction in each period – even the control periods! Probably, serial effects in the repeated measurements are masquerading as individual differences in the outcome over the treatment period. This is not HTE.

We can look at our replicate crossover trials (a type of n-of-1 trial), some having repeated measurements within each period, to explore this question. We can take a variable for which there was little evidence of HTE. Between-treatment consistency is poor with no person by treatment interaction.

These designs, and thereby variance components, are different. How is a person by treatment effect interaction (n-of-1 trial) the same as a person by time interaction within a single treatment period? How can modelling repeated measurements within a period, e.g. individual slopes, help quantify HTE?

The question was whether repeated measurements WITHIN a single treatment period is compatible with repeated administration of treatment-control cycles – as in sets of n-of-1 trials – for informing heterogeneity of treatment effects (HTE). We think not.

During the peer-review of our paper, “Understanding treatment response heterogeneity using randomised crossover trials: A primer for exercise and nutrition scientists”, an interesting question arose which @lorenzololli.bsky.social & I are now pursuing as our next project. osf.io/preprints/os...

For the love of god put the sample size in the abstract

✨SEPTEMBER 2025 ISSUE LINE UP✨

Can you believe it’s the penultimate issue of 2025?! It may be one of the last issues for this year but by no means is it the least. Check out what’s coming up next 🔥

Unilateral High-Load Resistance Training Increases Absolute but Not Relative Muscular Endurance in the Contralateral Untrained Limb To investigate whether unilateral resistance training can enhance absolute and relative muscular endurance in a trained arm and an untrained arm (cross-education of muscular endurance), and if this...

New work from our laboratory where we investigate the cross-education of local muscular endurance. A lot of work has focused on strength, much less has investigated endurance. Lot's of interesting follow-up ideas based on the results of this one #OleMissMuscle

www.tandfonline.com/doi/full/10....

The leaky pipe of clinical prediction models. by @maartenvsmeden.bsky.social‬ et al

You can have all the omni-omics data in the world and the bestest algorithms, but eventually a predicted probability is produced & it should be evaluated using well-established methods, and correctly implemented in the context of medical decision making.

statsepi.substack.com/i/140315566/...

Thanks to @lorenzololli.bsky.social here is the accepted (in IJSNEM) version of our paper, "Understanding treatment response heterogeneity using randomised crossover trials: A primer for exercise and nutrition scientists". This is prior to the proofing stage: osf.io/preprints/os...

Some Practical Guidelines for Effective Sample Size Determination Sample size determination is often an important step in planning a statistical study—and it is usually a difficult one. Among the important hurdles to be surpassed, one must obtain an estimate of o...

“One cannot avoid addressing the issues of effect-size elicitation (𝙞𝙣 𝙖𝙗𝙨𝙤𝙡𝙪𝙩𝙚 𝙩𝙚𝙧𝙢𝙨) and estimating the error variance, as difficult as these may be.

𝙎𝙩𝙖𝙣𝙙𝙖𝙧𝙙𝙞𝙯𝙚𝙙 𝙚𝙛𝙛𝙚𝙘𝙩𝙨 𝙙𝙤 𝙣𝙤𝙩 𝙩𝙧𝙖𝙣𝙨𝙡𝙖𝙩𝙚 𝙞𝙣𝙩𝙤 𝙝𝙤𝙣𝙚𝙨𝙩 𝙨𝙩𝙖𝙩𝙚𝙢𝙚𝙣𝙩𝙨 𝙖𝙗𝙤𝙪𝙩 𝙨𝙩𝙪𝙙𝙮 𝙜𝙤𝙖𝙡𝙨.”

www.tandfonline.com/doi/abs/10.1...

We just published a critical review of the KETO-CTA study — the first study to examine coronary plaque progression in Lean Mass Hyper-Responders (LMHRs) on a ketogenic diet.

Here’s why we believe the study’s results have been seriously misrepresented.

1/14

✨JULY 2025 ISSUE OUT NOW✨

🔗https://journals.humankinetics.com/view/journals/ijsnem/ijsnem-overview.xml?tab_body=latest-issue

Estimating the Replicability of Sports and Exercise Science Research - Sports Medicine Background The replicability of sports and exercise research has not been assessed previously despite concerns about scientific practices within the field. Aim This study aims to provide an initial es...

New Replication Project in sport and exercise science shares it results: Out of 25 replication studies performed, 56% yielded significant results, but only 7 (28%) revealed a similar effect size. Several problems related to the quality of are discussed.

link.springer.com/article/10.1...

Please people. It's not hard. In fact, it makes your life easier. And when you don't use CONSORT, you look like a novice.

Vitamin D Workshop NEXT VITAMIN D WORKSHOP: JUNE 24-27, 2025 MONTREAL, CANADA

I’m looking forward to presenting some of our research on the effect of exercise on vitamin D at the Vitamin D Workshop in Montreal next week.

vitamindworkshop.org/montreal-2025

I'm pleased to announce the publication of two important papers in Sports Medicine on the first every large replication project in sport and exercise science. Read the full papers:
lnkd.in/gH3NCqK5  
lnkd.in/gE7izySW

#SportsScience #EvidenceBasedPractice #Research #OpenScience #Replication

CONSORT 2025 Statement Updated Guideline for Reporting Randomized Trials

Authors, editors, reviewers, and other potential users should use CONSORT 2025 when writing and evaluating manuscripts of randomized trials to ensure that trial reports are clear and transparent.

Learn more in this Special Communication.

https://ja.ma/3TlnKQe

Individual variations in glycemic responses to carbohydrates and underlying metabolic physiology - Nature Medicine Deep phenotyping of responses to carbohydrate meals and mitigators revealed interindividual differences in postprandial glycemic responses that reflect underlying metabolic physiology, such as insulin resistance and beta cell dysfunction.

Variability in glycemic responses to carbohydrates reveals significant links to insulin resistance and metabolic profiles among individuals.

by Wu Y, Ehlert B (...) Snyder MP et 26 al. in Nat Med #MedSky

👉 get more here

📖 read the article:

20mph limits in London linked to sharp fall in road injuries and deaths, new report finds A new study published by Transport for London (TfL) has shown that the introduction of 20mph speed limits and zones on local authority-managed roads in London between 1989 and 2013 led to significant…

Study on London 20 mph limits shows:
- collisions ⬇️ 35%
- casualties ⬇️ 36%
- fatal/serious injuries ⬇️ 34%
- child casualties ⬇️ 46%
- child deaths ⬇️ 75%
- walkers, cyclists, motorcyclists killed/seriously injured ⬇️ 28%

etsc.eu/20mph-limits...