Matylda Zofia Kuzinska

Human liver immunology: from in vitro models to new insights - Cellular & Molecular Immunology Cellular & Molecular Immunology - Human liver immunology: from in vitro models to new insights

The liver balances immune tolerance and inflammation—but most liver models don’t.

In this new review, I break down human-specific systems to study liver–immune crosstalk.

From cocultures to organoids.

www.nature.com/articles/s41...

@bihatcharite.bsky.social

02.07.2025 14:35 — 👍 3    🔁 1    💬 0    📌 0

One minute in Kyiv

I continue sharing these moments with you to show Kyiv's beauty and strength.
Stop me when you get bored.

22.05.2025 13:27 — 👍 15504    🔁 1622    💬 466    📌 58

"Science is an investment.

We will put forward a new 500 million package for 2025-2027 to support the best and the brightest researchers and scientists from Europe and around the world."

— President @vonderleyen.ec.europa.eu at the ‘Choose Europe for Science' event at La Sorbonne 🇫🇷

05.05.2025 10:16 — 👍 974    🔁 304    💬 35    📌 49

So much fun at the @berlinliverlab.bsky.social outing — from laser tag battles to beers in the Berlin evening sun. Grateful for this brilliant, fun, and inspiring team! #LabLife #BerlinVibes @bihatcharite.bsky.social

02.05.2025 05:24 — 👍 3    🔁 1    💬 0    📌 0

This is figure 2, which shows single-cell characterization of the acute hyperinflammatory response to LPS administration.

A study in Nature Immunology uses a model of lipopolysaccharide injection in humans to characterize the transcriptomic landscape of bone marrow and blood immune cells during the hyperinflammatory and immunosuppressed phases of systemic inflammation. go.nature.com/44bj71Y

27.04.2025 19:26 — 👍 29    🔁 6    💬 0    📌 0

Multi-zonal liver organoids from human pluripotent stem cells - Nature Liver organoids derived from human induced pluripotent stem cells populations grown with ascorbate and bilirubin can be used to recapitulate differential zonal functions of human hepatocytes and for t...

#GastroEdPick Multi-zonal liver organoids from human pluripotent stem cells @nature.com www.nature.com/articles/s41...

22.04.2025 12:37 — 👍 4    🔁 1    💬 0    📌 0

Metabolism shapes life
EMBL Barcelona & @mpi-cbg.de researchers reveal how glycolysis drives early embryonic cell decisions.

The studies, published in Cell Stem Cell (@cp-cellstemcell.bsky.social), uncover the instructive potential of glycolysis.

www.embl.org/news/science...

16.04.2025 15:20 — 👍 54    🔁 25    💬 1    📌 2

Single-cell profiling of the human endometrium in polycystic ovary syndrome - Nature Medicine A transcriptomic atlas of the endometrium of women with polycystic ovary syndrome uncovers both disease signatures and potential therapeutic targets.

A transcriptomic atlas of the endometrium (the inner lining of the uterus) of women with polycystic ovary syndrome uncovers both disease signatures and potential therapeutic targets, according to a paper in Nature Medicine. 🧪

29.03.2025 22:32 — 👍 51    🔁 10    💬 0    📌 0

Woman in cancer remission for record 19 years after CAR-T immune treatment CAR-T-cell therapy treated a girl with a rare childhood cancer, raising hopes for future recipients of the approach.

CAR-T-cell therapy treated a girl with a rare childhood cancer, raising hopes for future recipients of the approach

https://go.nature.com/42XLYpK

17.02.2025 17:02 — 👍 127    🔁 20    💬 1    📌 3

A Novel Three-in-One Pancreatic Organoid An innovative organoid model mirrors the pancreas' complexity, generating all three key cell types to explore development and possible regeneration.

Check out this new article highlighting our postdoc @amandaanderssonr.bsky.social ’s work on a novel pancreatic organoid model that includes all three key cell types, offering new insights into pancreatic development: www.the-scientist.com/a-novel-thre...

13.02.2025 11:31 — 👍 10    🔁 6    💬 0    📌 0

Spatially restricted and ontogenically distinct hepatic macrophages are required for tissue repair scRNA-seq has uncovered ontogenically distinct hepatic macrophage populations, but their functions remain unclear. Here, De Ponti et al. identify recruited LAMs and resident LAM-like KCs in multiple l...

Super deep study:

Kupffer cells can become lipid-associated macrophages by uptake of injured cells

…and they repair liver tissue via TREM2

#macrophages #liver

www.cell.com/immunity/ful...

27.01.2025 16:23 — 👍 1    🔁 1    💬 0    📌 0

thank you!!! excited to be a part of such an amazing team!!

24.01.2025 21:35 — 👍 0    🔁 0    💬 0    📌 0

🎊Combining the first post of @berlinliverlab.bsky.social with a celebration of @matyldazkuzinska.bsky.social for getting a competitive BIH MD scholarship for her MD PhD thesis. Way to go!!! 🍾🥳

24.01.2025 20:39 — 👍 1    🔁 1    💬 1    📌 0