Heemskerk Lab

Cover: Immunofluorescence staining of phosphorylated FGFR1 (magenta), TBXT (yellow) and β-catenin (cyan) in 2D human gastruloids. The spatial pattern of phosphorylated FGFR1 matches ERK activity observed during primitive streak-like differentiation. See Research Article by Jo, Liu et al. (dev205459).

Issue 3 is complete!

On the cover: Immunofluorescence staining of phosphorylated FGFR1 (magenta), TBXT (yellow) and β-catenin (cyan) in 2D human gastruloids.

See the Research Article by Idse Heemskerk and colleagues (@heemskerklab.bsky.social) here: doi.org/10.1242/dev....

Endogenous FGFs drive ERK-dependent cell fate patterning in 2D human gastruloids Summary: In a 2D gastruloid model for human gastrulation, FGF4 and FGF17 signal through basolateral receptors to induce primitive streak-like cells and derivatives, potentially restricted by FGF8.

After being reviewed as a preprint in Elife our paper about endogenous FGF signaling in 2D human gastruloids is now published in Development:
journals.biologists.com/dev/article-...

Extended culture of 2D gastruloids to model human mesoderm development - Nature Methods This study reports an extended 2D gastruloid system for spatially modeling human mesoderm development.

Our work on mesoderm development in 2D gastruloids is now published in nature methods

www.nature.com/articles/s41...

YouTube video by robrouge71 French senator Claude Malhuret great speech about Trump subtitles english

Watch the France’s Senator Claude Malhuret speaking to his Government. Priceless.

youtu.be/m8qSZO4jvTI

Welcome to the Bluesky account for Stand Up for Science 2025!

Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide!

#scienceforall #sciencenotsilence

A bunch of people dressed in construction clothes stand around, watching as a single person digs a hole. The person digging the hole is labeled “faculty.” The people standing around watching are labeled “director, human resources,” “VP, research, innovation, and economic development,” “director, innovation management,” “AVP, institutional research,” “AVP, academic planning,” “AVP, faculty development,” “associate dean,” “dean,” “VP, finance,” and “provost”. The caption reads: “Due to cutbacks, we will need to reduce the number of faculty.”

#AcademicSky

Our "research station" is now on exhibit at the University of Michigan Museum of Natural History.