Single-cell proteomics sheds light on neutrophil diversity in glioblastoma - Nature Reviews Immunology
A preprint by Sadiku et al. characterizes neutrophil diversity in glioblastoma using a new workflow for single-cell proteomic profiling.
We (@walmsley-lab.bsky.social) are thrilled to have our pre-print highlighted by the Journal Club from @natrevimmunol.nature.com
We think single cell proteomics has the capacity to revolutionise our understanding of neutrophil functional heterogeneity, shown here in glioblastoma.
11.11.2025 14:25 — 👍 8 🔁 2 💬 0 📌 0
🎉Thrilled to share that my Wellcome ECA has been funded.🎉 I'll be using ultra-sensitive proteomics—mini-bulk and single-cell—to map neutrophil functional states in COPD.
Hugely grateful to @wellcometrust.bsky.social, my host @walmsley-lab.bsky.social and @edinuni-irr.bsky.social colleagues 🙏.
06.11.2025 19:05 — 👍 39 🔁 1 💬 9 📌 0
Students celebrate their IRR internship | Institute for Regeneration and Repair | Institute for Regeneration and Repair
For four weeks this summer, IRR hosted local high school students as part of both the BioQuarter’s Summer Interns and University’s Career Ready programmes.
Students celebrate their IRR internship 🧑🔬
For four weeks this summer, IRR hosted local high school students as part of both the Edinburgh BioQuarter’s Summer Interns and @edinburgh-uni.bsky.social’s Career Ready programmes.
Read about the experience on IRR stories: edin.ac/4oPP33G
25.08.2025 14:05 — 👍 5 🔁 3 💬 0 📌 0
🚨 New preprint alert!
@pranvera.bsky.social uses single-cell proteomics + #Spectronaut® to decode neutrophil roles in glioblastoma.
1,100 proteins from single cells—revealing dynamic states in brain cancer.
🔬 Read more: www.biorxiv.org/content/10.1...
15.08.2025 11:34 — 👍 2 🔁 1 💬 0 📌 1
Excellent work!! I just love the term Mini-Bulk so I had chatGPT help me whip something up
28.07.2025 23:13 — 👍 12 🔁 3 💬 3 📌 0
In summary, we do single cell proteomics of glioblastoma neutrophils and find exciting functional states invisible to scRNAseq which further define the roles that neutrophils play within glioblastomas, showing some pro-tumorigenic and anti-tumorigenic populations and properties
27.07.2025 12:41 — 👍 3 🔁 1 💬 1 📌 0
So excited to see this powerful work out from @ajbrenes.com and team. Neutrophils never cease to amaze. Read on for an awesome science thread. Pushing the limits of single cell proteomics at ~30 picograms per cell 🤯
27.07.2025 14:30 — 👍 9 🔁 3 💬 0 📌 0
I'll soon be advertising for a 3 year postdoc to join our lab at @edinuni-irr.bsky.social exploring #macrophages in salivary gland #development. Candidates should have a strong background in immunology/macrophage biology and/or developmental biology & key skills as below. Informal enquiries welcome!
26.07.2025 12:16 — 👍 23 🔁 17 💬 1 📌 1
A nice thread explaining our recent work using mass spectrometry-based single cell proteomics to study tumour associated neutrophils in human glioblastoma.
Exciting populations with clear functional states that correlate well with neutrophil effector functions. Go take a look
27.07.2025 13:53 — 👍 6 🔁 1 💬 0 📌 0
New work from @soehnleinlab.bsky.social
09.01.2025 21:00 — 👍 4 🔁 1 💬 0 📌 0
Just less than a month to apply for this exciting PhD project working toward #salivarygland #regeneration after #cancer treatment.
17.12.2024 08:24 — 👍 4 🔁 5 💬 0 📌 0
Thinking of starting your own research group? Why not choose the IRR?
We spoke to 2019 UKRI Future Leaders Fellow Rod Mitchell about the fellowship and the opportunities it can bring.
🎞️Watch the video and find out more on our website: regeneration-repair.ed.ac.uk/work-with-us...
17.12.2024 17:22 — 👍 5 🔁 5 💬 0 📌 1
What a treat to have @ajmhowden.bsky.social visiting @edinuni-irr.bsky.social to talk to us about studying B cell metabolism and protein synthesis capacity using proteomics.
03.12.2024 11:14 — 👍 5 🔁 1 💬 0 📌 0
A group of researchers leading over a table full of papers and posters, deep in conversation.
🥳As we approach the end of 2024, we’re celebrating our year of fantastic community and scientific achievement with our #12DaysOfResearch series.
Stay tuned for our posts throughout December, reminiscing on the incredible work achieved by our IRR colleagues.
02.12.2024 12:21 — 👍 6 🔁 1 💬 0 📌 0
The Princess Royal and two women scientists laughing in conversation wearing lab coats.
A student stands in a crowd looking past the camera.
A group of scientists wear lab coats in the facilities. They look past the camera at a speaker not fully visible.
The Princess Royal stands next to an unveiled plaque for the new IRR building.
1st Day of Research: Grand Opening of IRR South 🍾
In January we were joined by Chancellor of the University of Edinburgh, Her Royal Highness The Princess Royal, to officially open the state-of-the-art IRR South building.
📰 Read more here: edin.ac/4eoFtym
#12DaysOfResearch
02.12.2024 12:24 — 👍 5 🔁 3 💬 0 📌 0
Join us!! On here where the sky is blue, & in the Society. A fantastic place to talk #cytokines, #interferons, the coolest #immunology, and a very nice place to meet new people, make new friends, & start new collaborations!
25.11.2024 14:21 — 👍 19 🔁 4 💬 0 📌 0
📣 Announcing our latest BSI Career Enhancing Grant winners!
Congratulations to our 12 members who have been awarded #funding to advance their #CareerDevelopment 🚀
Discover the projects we're supporting to boost #CareersInImmunology here 👉 bit.ly/4fXdtD1
1/2
21.11.2024 16:06 — 👍 16 🔁 3 💬 1 📌 4
Dr Neil Ryan, stood in a lab/office space, pointing at a book on modern pathology that a colleague is holding
Dr Neil Ryan, Clinical Lecturer at our Centre for Reproductive Health and the Institute for Genetics and Cancer at UoE, has been awarded an Eve scholarship from The Eve Appeal
and North West Cancer Research
regeneration-repair.ed.ac.uk/crh-research... Congratulations Neil!
22.11.2024 16:07 — 👍 5 🔁 2 💬 0 📌 0
Several Walmsley lab members are already on Bluesky. Please give them a follow if you haven't already:
@patriciacoelho.bsky.social
@pranvera.bsky.social
@mas-g.bsky.social
@alejandrobrenes.bsky.social
#neutrophil #teamNeutrophil
21.11.2024 21:02 — 👍 5 🔁 0 💬 0 📌 0
Hello Bluesky & #immunosky we are a lab researching how oxygen and nutrient availability reprogram #neutrophils
We are based in the Centre for Inflammation Research at @edinuni-irr.bsky.social
Link up if you're a fan of the most interesting immune cell #teamNeutrophil
21.11.2024 19:34 — 👍 19 🔁 5 💬 2 📌 0
Researcher in immunology and rheumatoid arthritis @mcbi-amsumc.bsky.social. Long-time fan of the neutrophil. Passionate about living sustainably.
Bluesky account for the journal Nature Reviews Immunology https://www.nature.com/nri/ Skyquakes from the editors.
Group leader at MRC Human Genetics Unit, University of Edinburgh. Interdisciplinary research on disease #epigenetics. Part-time solo dad. Occasional music and climbing.
https://institute-genetics-cancer.ed.ac.uk/research/research-groups-a-z/sproul-group
Professor of Immunology @Maynooth University, focused on Cell & Gene Therapy, mesenchymal stromal cells and MIF. Passionate about supporting and mentoring the next Generation of Scientists. Mum of two, patient wife of a Liverpool super-fan!
Associate Professor at the CBRB at Imperial College London. Studying how gut microbiota-mediated colonisation resistance protects the host against infections. https://www.imperial.ac.uk/people/julie.mcdonald
We are the University of Edinburgh’s College of Medicine and Veterinary Medicine; a community united by a shared ambition to turn ideas into positive health outcomes for humans, animals and our planet.
A research group at the Kennedy Institute of Rheumatology @ox.ac.uk @ndorms.bsky.social trying to understand how the inflammatory response is controlled on the molecular level
https://www.kennedy.ox.ac.uk/research/research-groups/genomics-of-inflammation
Principal investigator at the University of Edinburgh.
Research on the systemic immune response to stroke and complications of stroke recovery. #Bcells #infection #GIdysfunction #cognitivedecline
Wellcome Sir Henry Dale fellow
MSc Critical Care | Postgraduate Professional Development | Part Time | Online Study | International | Multidisciplinary
https://clinical-sciences.ed.ac.uk/msc-in-critical-care
Precision Medicine PhD student researching heavy menstrual bleeding 🩸| Maybin Lab 🔬
Our mission is to improve the lives of people living with genetic disease and cancer through research.
Edinburgh Immunology Group | EIG
Regional hub of the British Society for Immunology. Connecting researchers, clinicians & students across Edinburgh to advance immunology through collaboration, education & outreach. #Immunology
Precision medicine PhD student studying the role of immune cells during endometrial repair 🩸🔬 Early career representative for the Society of Reproduction and Fertility.
Immunologist interested in how the genome works
https://www.babraham.ac.uk/our-research/lymphocyte/martin-turner
@babrahaminst.bsky.social
/ the genome is a zipfile for the transcriptome / immunity /ageing / & the History of Science/ germinal centres
Professor of Translational Immunology • Infection & Immunity • Public Involvement and Engagement • Scientist and migrant • Superbugs
Postdoc with Denby Lab | Interested in myeloid cells, fibrosis and kidney disease 🫘
Our group of research is based at Imperial College and NHLI looking at blood vessels and mast cells in the lungs 🔬
We are funded by the Wellcome Trust, BHF and Acteria foundation.
The International Cytokine & Interferon Society (ICIS ), is the premier organization promoting the field of cytokine & interferon biology across many different research disciplines, including cytokine biomarkers & cytokine therapeutics.
Research group within the Institute of Immunity & Transplantation, UCL. Interested in liver #immunology, immunometabolism, adaptations of tissue resident T cells, stromal cells & fibrosis | UKRI FLF 👩🔬🧪
#liversky #immunosky
Postdoc in Prof David Ferenbach’s lab at the @edinuni-irr.bsky.social exploring the role of senescence in chronic kidney disease. I venture into all things epithelial. Committee member of the regional BSI @edinburghimmuno.bsky.social
