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Dr Sanil Rege

@drsanil.bsky.social

Psychiatrist | Educator | Neuroscience Enthusiast | Exploring the intersection of biology, psychology & human behaviour | Sharing insights, ideas & stories to simplify complexity.

603 Followers  |  68 Following  |  93 Posts  |  Joined: 13.11.2024
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Posts by Dr Sanil Rege (@drsanil.bsky.social)

Depression Isn’t One Thing — Why the Wrong Treatment Keeps Failing
YouTube video by Dr. Rege Depression Isn’t One Thing — Why the Wrong Treatment Keeps Failing

Depression isn’t one thing. 🚨

Same label. Different brain states. Different drivers. Different treatment responses.

New video 👉Depression Isn’t One Thing - Why the Wrong Treatment Keeps Failing
youtu.be/-AvODpgp8OQ

08.03.2026 12:05 — 👍 0    🔁 0    💬 0    📌 0
Stop Taking Random ADHD Supplements — Use This 5-Step Bottleneck
YouTube video by Dr. Rege Stop Taking Random ADHD Supplements — Use This 5-Step Bottleneck

Supplements for ADHD?🚨

Top 5 solutions to specific bottlenecks.

Each one maps to a different problem:
1. a dopamine limiting step
2. signal-to-noise regulation
3. membrane signalling efficiency
4. timing (circadian delay)
5. effort physiology / cognitive endurance
Names 👇
youtu.be/hYwGWx1UNLI?si…

22.02.2026 12:16 — 👍 1    🔁 0    💬 0    📌 0

Now recommended 75-100 ng/ml

22.02.2026 12:14 — 👍 0    🔁 0    💬 1    📌 0
Preview
ADHD and Sleep Disorders: Understanding the Link Between ADHD, Insomnia, and Circadian Rhythm Dysregulation Explore the bidirectional relationship between ADHD and sleep disorders, delving into the pathophysiology, diagnosis, and management strategies that address both conditions for better quality of life.

Type 2 narcolepsy is a very comorbidity with ADHD. Can present like this. Here is an article which goes into details of the range of sleep issues psychscenehub.com/psychinsight...

22.02.2026 12:08 — 👍 0    🔁 0    💬 1    📌 0
New ADHD Medication That Targets Serotonin - Centanafadine Explained
YouTube video by Dr. Rege New ADHD Medication That Targets Serotonin - Centanafadine Explained

Serotonin enters the ADHD conversation. 🚨

New video on Centanafadine, a triple reuptake ADHD medication (NE + DA + 5-HT) that’s now under FDA Priority Review.

Video 👉
youtu.be/DKWGO3BzFCI

15.02.2026 10:45 — 👍 0    🔁 0    💬 0    📌 0
The Hidden Risk of Hyperbolic Tapering Antidepressants (No One Talks About This)
YouTube video by Dr. Rege The Hidden Risk of Hyperbolic Tapering Antidepressants (No One Talks About This)

Why Hyperbolic tapering of antidepressants may be making things worse 🚨

We’re told the safest way is :

Go slower. Hyperbolic taper. Micro-reduce.

And for many people, that’s true.

BUT

What if, in some cases, the tapering process is the issue?

Video 👉 youtu.be/oZxe_EkgXP8?si…

26.01.2026 04:52 — 👍 1    🔁 0    💬 0    📌 0
ADHD + Restless Legs + Bad Sleep: The Dopamine–Iron Link Nobody Explains
YouTube video by Dr. Rege ADHD + Restless Legs + Bad Sleep: The Dopamine–Iron Link Nobody Explains

One of the most common psychiatric interventions I implement in clinical practice is Iron Supplementation. 🚨

Cos…

Brain iron ≠ serum iron.

This matters in ADHD management

In this video, I link iron to clinical practice (ADHD and RLS)

Video 👉 youtu.be/vf7ol8mpZjk?si…

19.01.2026 07:15 — 👍 1    🔁 1    💬 0    📌 1
Here’s What ADHD Stimulants Actually Do. (Why Calm Isn’t Enough)
YouTube video by Dr. Rege Here’s What ADHD Stimulants Actually Do. (Why Calm Isn’t Enough)

New video 🚨
I cover:

1. The transformation trap (relief ≠ function)

2. The cue–reward trap (when meds become the reward)

3. What stimulants actually do: improve signal clarity, not motivation

Video 👉 Here’s What ADHD Stimulants Actually Do. (Why Calm Isn’t Enough)
youtu.be/4c-AICHiBuc

11.01.2026 13:21 — 👍 1    🔁 0    💬 0    📌 0
Why Aftersun Hurts More After It Ends
YouTube video by Dr. Rege Why Aftersun Hurts More After It Ends

New video👇Why AfterSun Broke Me

“Brought me to tears. Beautifully said and I related so much. Bittersweet.”

“Beautiful video. I had a very similar experience watching it, and watching this analysis. …… Brilliant.”

youtu.be/0YyX22DygFE

29.12.2025 03:07 — 👍 0    🔁 0    💬 0    📌 0
Why Your Treatment Isn’t Working: The 3 Questions Your Brain Needs Answered
YouTube video by Dr. Rege Why Your Treatment Isn’t Working: The 3 Questions Your Brain Needs Answered

𝐓𝐫𝐞𝐚𝐭𝐦𝐞𝐧𝐭 𝐫𝐞𝐬𝐢𝐬𝐭𝐚𝐧𝐭”… 𝐨𝐫 𝐣𝐮𝐬𝐭 𝐭𝐫𝐞𝐚𝐭𝐦𝐞𝐧𝐭 𝐰𝐢𝐭𝐡𝐨𝐮𝐭 𝐝𝐢𝐫𝐞𝐜𝐭𝐢𝐨𝐧 ? 🚨

In this new video, I cover:

1. Why treatments appear to “fail” when the brain has no clear prediction

2. The 3 questions for specific, testable targets

3. Why function is the real marker of progress

Video 👉 youtu.be/Vi9Opuvwk4s?si…

07.12.2025 08:54 — 👍 0    🔁 0    💬 0    📌 0
Stop Prescribing “Exercise”—Prescribe Movement for Mental Health (Works Faster)
YouTube video by Dr. Rege Stop Prescribing “Exercise”—Prescribe Movement for Mental Health (Works Faster)

New Video 🚨👉telling people to “exercise”… for many, that advice backfires.

It’s movement , not exercise, that regulates the brain.

I cover 👇

• why motivation comes after action

• the brain pathways that help people get started

• a simple movement script

Watch video 👇
youtu.be/NntTyHygGNU

30.11.2025 18:15 — 👍 0    🔁 0    💬 0    📌 0
Post image

Yes this is an important interaction for some. GLP-1 agonists modulate Mesolimbic reward pathways and can reduce DA ‘reward’ transmission.
This is also the reason why there is a signal for depression
ADHD has reward sensitivity as an important part of the condition.

30.11.2025 18:03 — 👍 1    🔁 0    💬 1    📌 0
Your Brain Doesn’t Care If You’re Happy – Your Brain Wants THIS Instead
YouTube video by Dr. Rege Your Brain Doesn’t Care If You’re Happy – Your Brain Wants THIS Instead

🚨Is this the worst question in psychiatry?
“How’s your mood?” ⁉️

Clinically, it tells us almost nothing.

“Mood” is not a feeling, not happiness, and not sadness -
but something far stranger:

A rolling measure of prediction success vs failure.

🎥 New video 👉
youtu.be/zUkm8jR6BM8

23.11.2025 10:57 — 👍 0    🔁 0    💬 0    📌 0
The Truth About Modafinil & Armodafinil: Not the Limitless Pill You Think
YouTube video by Dr. Rege The Truth About Modafinil & Armodafinil: Not the Limitless Pill You Think

New video 🚨 Modafinil vs Armodafinil

I cover:

-How they work on dopamine, norepinephrine, orexin & histamine

-Role in narcolepsy, shift work, sleep apnoea, depression & ADHD

-The idea of “performance debt”

-Side effects, and risks

Watch here👉 youtu.be/J3nzq2GIPUo

17.11.2025 01:14 — 👍 2    🔁 0    💬 0    📌 0

If you deal with "chronic pain", this video will give you something to think about.

09.11.2025 18:39 — 👍 1    🔁 1    💬 0    📌 0
Pain Isn’t in Your Body — It’s Your Brain’s ‘Danger Mode’
YouTube video by Dr. Rege Pain Isn’t in Your Body — It’s Your Brain’s ‘Danger Mode’

New video 👉Why Chronic Pain Persists: Neurobiological Mechanisms 🚨

I cover:
👉Why pain persists after tissues heal

👉Central sensitisation, neuroinflammation, descending inhibition

👉conceptualising pain beyond nociception.. the human aspects

Video 👉 youtu.be/ovMOmAbxbkQ?si…

08.11.2025 14:20 — 👍 2    🔁 2    💬 0    📌 1
Your ADHD Child Isn’t Misbehaving — Their Brain Is Trying To Tell You Something
YouTube video by Dr. Rege Your ADHD Child Isn’t Misbehaving — Their Brain Is Trying To Tell You Something

New video. 🚨

-Not about Ritalin or Dex.
-Not about making a child sit still or focus harder

This is about a core neurobiological system the Brain needs -
and the one modern childhood has systematically ‘stripped’ away.

The System is PLAY

Here’s why it matters 👉 youtu.be/PwmTLNUTWZQ?si…

01.11.2025 11:20 — 👍 0    🔁 0    💬 0    📌 0

Very interesting. We know insufficient sleep reduces stimulant effectiveness, and once addressed this improves most cases where patients report medications seems less effective. Will have to start incorporating adenosine into those discussions. /1

18.10.2025 14:02 — 👍 1    🔁 1    💬 0    📌 0
SNRIs Are NOT All the Same—Here’s What You Need to Know
YouTube video by Dr. Rege SNRIs Are NOT All the Same—Here’s What You Need to Know

Try this SNRIs Are NOT All the Same—Here’s What You Need to Know
youtu.be/MO3IKlKM34M

18.10.2025 13:07 — 👍 0    🔁 0    💬 2    📌 0
When Dopamine Backfires: Why Too Much Can Make You Tired
YouTube video by Dr. Rege When Dopamine Backfires: Why Too Much Can Make You Tired

New video 🎥 The Dopamine Paradox🚨

“Doesn’t last long enough …
Not as strong”

Seeing more patients on increasingly higher stimulant doses, sometimes above recommended limits …

🚩 But when doses keep needing to go up, that’s a red flag clinicians need to notice.
👇

Link 👉 youtu.be/qYfrHCbGbbU?si…

18.10.2025 13:06 — 👍 1    🔁 0    💬 1    📌 0
Procrastination Isn’t Laziness — It’s a Dopamine Timing Glitch (and Here’s How to Fix It)
YouTube video by Dr. Rege Procrastination Isn’t Laziness — It’s a Dopamine Timing Glitch (and Here’s How to Fix It)

Procrastination Isn’t Laziness — It’s a Dopamine Timing Glitch (and Here’s How to Fix It)
youtu.be/slwjAIaePPU

12.10.2025 16:49 — 👍 1    🔁 0    💬 0    📌 0
Kratom: Stimulant, Opioid… or Risk You’re Overlooking?
YouTube video by Dr. Rege Kratom: Stimulant, Opioid… or Risk You’re Overlooking?

Kratom Explained: Stimulant, Opioid, or Danger? 🚨

Kratom is marketed as a natural remedy - but its effects are not without risks.

I break down:

👉Pharmacology
👉Short & Long Term Effects
👉Regulatory action and more... 

Link 👉 youtu.be/rEjIVyJsANM?...

#Kratom

27.09.2025 12:49 — 👍 0    🔁 0    💬 0    📌 0
ADHD & Autism (AuDHD): Why Stimulants Work Differently (and What to Try Instead)
YouTube video by Dr. Rege ADHD & Autism (AuDHD): Why Stimulants Work Differently (and What to Try Instead)

AuADHD & Stimulants 🚨
Ever had patients with ASD + ADHD respond atypically to stimulants?

“Makes me tired”
“I was anxious.”

I cover:

-Why the ‘autistic brain’ processes stimulants differently

-Clinical signs to watch for

-Strategies to improve outcomes

Video 👉 youtu.be/dLVzwNp9GMY?si…

20.09.2025 12:09 — 👍 3    🔁 1    💬 0    📌 0
7 Science-Backed Habits to Switch Off Your Brain’s Overthinking Circuit
YouTube video by Dr. Rege 7 Science-Backed Habits to Switch Off Your Brain’s Overthinking Circuit

𝐍𝐞𝐰 𝐫𝐞𝐥𝐞𝐚𝐬𝐞 🎥
𝐏𝐚𝐭𝐢𝐞𝐧𝐭𝐬 𝐨𝐟𝐭𝐞𝐧 𝐬𝐚𝐲: “𝐈 𝐣𝐮𝐬𝐭 𝐜𝐚𝐧’𝐭 𝐬𝐰𝐢𝐭𝐜𝐡 𝐨𝐟𝐟.”🚨

In this video, I explore the Default Mode Network (DMN) - the brain’s “overthinking circuit.”

Video 👉 youtu.be/JWpxycc6iKQ?si…

24.08.2025 07:52 — 👍 3    🔁 0    💬 0    📌 0
ADHD Burnout & Autistic Meltdowns: The Hidden Brain Circuit
YouTube video by Dr. Rege ADHD Burnout & Autistic Meltdowns: The Hidden Brain Circuit

Interoceptive Awareness and its role in ADHD and ASD ‘Burnout’ 🚨

Interoceptive awareness is the brain’s ability to detect and integrate internal bodily signals

Video 👇
youtu.be/ONM8YifTjf4

In ADHD & Autism, brain regions like the insula or ACC can misread or miss key physiological signals.

22.08.2025 07:53 — 👍 3    🔁 0    💬 0    📌 0
ADHD Burnout & Autistic Meltdowns: The Hidden Brain Circuit
YouTube video by Dr. Rege ADHD Burnout & Autistic Meltdowns: The Hidden Brain Circuit

Interoceptive Awareness and its role in ADHD and ASD ‘Burnout’ 🚨

Interoceptive awareness is the brain’s ability to detect and integrate internal bodily signals

Video 👇
youtu.be/ONM8YifTjf4

16.08.2025 14:49 — 👍 0    🔁 0    💬 0    📌 0
Wired All the Time? Your Brain Might Be Stuck in Overdrive (Not Anxiety)
YouTube video by Dr. Rege Wired All the Time? Your Brain Might Be Stuck in Overdrive (Not Anxiety)

“Wired… and tired.”🚨

Often mislabelled as anxiety, this state is frequently driven by noradrenergic hyperarousal

In this video, I explore:

– The difference between anxiety, hyperarousal & agitation

– The circuits involved

-A 4-step practical framework

Video 👇 youtu.be/PHLSQVuNxv4?...

10.08.2025 09:42 — 👍 1    🔁 0    💬 0    📌 0
How Porn Hijacks Your Brain — Addiction, Erectile Dysfunction & Dopamine Explained
YouTube video by Dr. Rege How Porn Hijacks Your Brain — Addiction, Erectile Dysfunction & Dopamine Explained

The average age of first porn exposure is just 11.*🚨

In this video, I explore:

1. How porn ‘hijacks’ dopamine & motivation

2. Brain changes

3. Hypersexual disorder & POPU

4. Evidence-based treatments

*range of surveys show ages between 10-13

03.08.2025 11:05 — 👍 1    🔁 0    💬 0    📌 0
Burnout Isn’t Laziness—It’s a Hidden Brain Shutdown Called Performance Debt
YouTube video by Dr. Rege Burnout Isn’t Laziness—It’s a Hidden Brain Shutdown Called Performance Debt

The Most Expensive Debt of All? Understanding Burnout as Performance Debt 🚨

In this video, I cover the neurobiology and strategies to start paying it back - clinically and practically 👇

🔗 👉 youtu.be/AP_GTgslEPM?si…

#Burnout #PerformanceDebt #MentalHealth

29.07.2025 12:46 — 👍 3    🔁 0    💬 0    📌 0
The Truth About Methylene Blue — Hidden MAOI Risks Biohackers Miss
YouTube video by Dr. Rege The Truth About Methylene Blue — Hidden MAOI Risks Biohackers Miss

New video 🚀- RFK Jr. went viral using methylene blue mid-flight. 🚨

But few realise what he was really taking.

In this video, I explain:

– MOA
– Dose-response & psychiatric implications
– Biohacking myths vs clinical pharmacology
– What clinicians & patients need to know
youtu.be/qDYzyq1WcyM

04.07.2025 21:23 — 👍 0    🔁 0    💬 0    📌 0