Andrew DeSio BBBBCCCCCCCIDPPPPS

Investigating the Transfer of Lisinopril Into Human Milk: A Quantitative Analysis - PubMed Lisinopril is commonly prescribed to manage conditions such as hypertension and heart failure. Although concerns about fetal toxicity have traditionally limited the use of lisinopril in women of repro...

Just gotta say how much I appreciate simple little studies like this that save a lot of wasted energy looking for alternatives for patients that need meds while breastfeeding. So simple yet so reassuring. pubmed.ncbi.nlm.nih.gov/39405564/

It’s true what they say about reviewer 2! Time to fix up these manuscripts and resubmit, womp womp

Enjoying a nice comfy break from social media and capturing a couple top 3 finishes while that’s still achievable! Gotta get better about coming back here, feel like I’m just not as caught up with the latest lit these days!

Say It Ain't Steno: Stenotrophomonas maltophilia Review Podcast Episode · Breakpoints · 02/28/2025 · 1h 12m

podcasts.apple.com/us/podcast/b...

This’ll be a great one!

These won’t last, but I’ll take the Ws and podiums when I can!

Is fifth third just like, the worst bank?

Dang, first manuscript rejected from JTACS. At least lots of helpful feedback, hopefully we can rework things a bit and get it accepted somewhere.

Fingers still crossed on the prospective paper, hopefully that one makes it!

Wonder how much it’ll cost! Saves like, a minor amount of trouble for my splenectomies

This line is exhausting every time. “Somebody should look into that” like these drugs and most of the rest have not been thoroughly investigated.

Definitely some outliers that deserve some more attention but vaccines, SSRIs? Come on.

Not a lot of MRSA? Sounds perfect to me

It seems like there’s evidence to move away from clinda, if we’re ok with soft call cases getting doses of linezolid instead

ONE ANTIBIOTIC PK TABLE TO RULE THEM ALL

Absorption takes drug into blood from GI,
Vd spreads drug out to where bug calls home.
And after bacteria are doomed to die,
The drug’s eliminated on the porcelain throne

In the Land of Notion where this table doth lie…

#idSky #microsky #pharmsky #medsky

Always love the “they may have nec fasc” diagnosis as the patient rests comfortably in a general medicine bed

Yeah, not much of a choice anymore. We’re just kinda stuck for a while

I haven’t been doing much lately, kinda feel bad! Too much real life to post. Doomscrolling on here also kinda takes a toll

I was really hoping this would be my year to utilize some of the healthcare, dang.

Thanks! Didn’t have access to the full text so really appreciate it!

At 12-month follow-up, primary outcome data were available for 846 (90%) patients. Treatment failure occurred in 153 (34%) of 452 patients in the antibiotic group, compared with 28 (7%) of 394 in the appendicectomy group (difference 26·7%, 90% CI 22·4–30·9).

Finally!

Antibiotics are not non-inferior to appendectomy despite a generous 20% non-inferiority margin

They are actually inferior: www.thelancet.com/journals/lan... in the @thelancet.bsky.social

#MedSky

Dang, that’s a really generous NI margin… what was the justification for that?

The new sets 😂😂

I usually seek a nephrology consult in CKD stage 0a, before the kidneys even begin to suspect they are being damaged

Love this one! When the WBCs are like 12, love to cite this study!

Current Pyuria Cutoffs Promote Inappropriate Urinary Tract Infection Diagnosis in Older Women The degree of pyuria can help distinguish urinary tract infection (UTI) in older women from asymptomatic women with and without bacteriuria. We demonstrate

Also I must have misremembered, this study found a cut-off of 284 WBCs for older women with UTI

academic.oup.com/cid/article/...

Love this since every lab I’ve seen has topped out at 200+! Think my current one is 180+, with abnormal lab reported at >8 😢

Important article for #AMSSky, #TxID, #UTISky, and #IDSky in @cidjournal.bsky.social:

In neutropenic & non-neutropenic cancer patients w/ & w/o catheters, the absence of nitrite/leukocyte esterase or WBC<10 had high NPV for clinically significant bacteriuria

academic.oup.com/cid/advance-...

Impact of Fluconazole Resistance on the Outcomes of Patients With Candida parapsilosis Bloodstream Infections: A Retrospective Multicenter Study Despite global concerns about fluconazole resistance in Candida parapsilosis, its impact on mortality remains unexplored. Our study found no increased mort

🆕💫Multicenter retrospective study @cidjournal.bsky.social
Impact of Fluconazole Resistance on the Outcomes of Patients With Candida parapsilosis Bloodstream Infections #idsky #EMIMCC
academic.oup.com/cid/advance-...

Those people clearly haven’t played one or the other then. Just from spending any amount of time in Caesar 3, it’s pretty clear the systems aren’t quite as refined and the graphics are a bit of a step back (imo, although dif art style too)

NEW PREPRINT!

Enjoyed working with @tom-parks.bsky.social and @petedodd24.bsky.social on immortal time bias

In its simplest form, ITB results from misallocation of person time, i.e. pre treatment time in intervention group being counted as time on treatment

www.medrxiv.org/content/10.1...

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Ertapenem please, stewardship stewardship stewardship! 😃