Jiménez-Ruiz Lab's Avatar

Jiménez-Ruiz Lab

@jimenezruizlab.bsky.social

Parasitologist @ LMU Munich | Chair of Experimental Parasitology | Exploring non-histone methylation in Toxoplasma gondii and beyond | #Methylation #Parasitology #MolecularBiology

377 Followers  |  287 Following  |  12 Posts  |  Joined: 15.11.2024
Posts Following

Posts by Jiménez-Ruiz Lab (@jimenezruizlab.bsky.social)

Luminal acetylation of microtubules is not essential for Plasmodium berghei and Toxoplasma gondii survival Luminal acetylation of microtubules is not essential for Plasmodium berghei and Toxoplasma gondii survival – For full text please see the pdf.

🎉 And to finish a great year… our latest paper is out!
We show that α-tubulin K40 acetylation is not essential for Toxoplasma gondii or Plasmodium berghei, highlighting the plasticity of parasite microtubule regulation.
#Apicomplexa #Toxoplasma #Plasmodium #Microtubules #CellBiology
Read it here:

18.12.2025 10:44 — 👍 3    🔁 0    💬 0    📌 0
Post image

Do you want to join a community working to reduce the devastating toll of #malaria by pushing forward new ideas, innovations, and strategies? 🦟 🧬

Registration is now open for #EMBLMalaria: https://s.embl.org/bmp26-01-bl

✍️ Submit your abstract by 18 Feb
🗓️ 27 – 29 May 2026

#BioMalPar

02.12.2025 13:00 — 👍 4    🔁 2    💬 0    📌 5
Post image

Excited to release the Herculean efforts of @scottchisholm.bsky.social &Co. defining the subcellular #hyperLOPIT spatial proteome of #Plasmodium schizonts. Proteomes defining 24 subcellular niches, including exported compartments in the blood cell, are identified.
www.biorxiv.org/content/10.1...

28.11.2025 08:30 — 👍 45    🔁 18    💬 2    📌 4

This work was carried out in collaboration with Dr. Simone Mattei (EMBL. Heidelberg) and Oliwia Koczy, who developed the cryo-CLEM approach used in this study. @simonemattei.bsky.social

28.11.2025 11:41 — 👍 0    🔁 0    💬 0    📌 0

We identified two key factors for conoid formation: CGP stabilises preconoidal rings, while ASAF1 positions the conoid complex and acts as a scaffold, also supporting SPMT assembly. Both are essential for parasite division and invasion.

28.11.2025 11:41 — 👍 0    🔁 0    💬 1    📌 0
Video thumbnail

Our new paper is out in Nature Communications! 🎉
We explore how Toxoplasma gondii organizes parasite development, combining cell biology and expansion microscopy to reveal new structural insights.
#Toxoplasma @meissnerlab.bsky.social @natcomms.nature.com
www.nature.com/articles/s41...

28.11.2025 11:41 — 👍 22    🔁 6    💬 2    📌 0
Post image

Save the date‼️

💡 More information coming soon about registration and the scientific program.

#TOXO18 #Toxoplasma #Immunoparasitology #Buzios2026 #ScienceByTheSea

23.10.2025 17:30 — 👍 6    🔁 7    💬 0    📌 0

New on bioRxiv!
Our manuscript shows how the methyltransferase PCKMT primes the conoid by retaining Formin1 for motility initiation in Toxoplasma gondii, working with AKMT to activate the parasite’s motility machinery.
#Toxoplasma #Apicomplexa #Methylation #ParasiteMotility

07.11.2025 05:44 — 👍 5    🔁 0    💬 0    📌 0
Vesicle adaptors in malaria parasites show conservation and flexibility of protein sorting machinery Cubillán-Marín et al. find that the vesicle adaptors AP-1, AP-3, and AP-4 are all important for the survival of malaria blood-stage parasites and that thes

See companion study from Grech et al. @jimenezruizlab.bsky.social @meissnerlab.bsky.social: rupress.org/jcb/article/...

13.10.2025 20:45 — 👍 1    🔁 2    💬 0    📌 0

Excited to share our new paper!
Tepsin and AP4 mediate transport from the trans-Golgi to the plant-like vacuole in Toxoplasma gondii.

A great collaboration between the Meissner, Jiménez-Ruiz, and Dacks labs 🙌

#Toxoplasma #Apicomplexa #Golgi #CellBiology #Parasites

20.10.2025 13:36 — 👍 9    🔁 4    💬 0    📌 0
Vesicle adaptors in malaria parasites show conservation and flexibility of protein sorting machinery Cubillán-Marín et al. find that the vesicle adaptors AP-1, AP-3, and AP-4 are all important for the survival of malaria blood-stage parasites and that thes

See companion study from the Tobias Spielmann group: rupress.org/jcb/article/...

13.10.2025 20:15 — 👍 2    🔁 2    💬 0    📌 0
Video thumbnail

Grech, @jimenezruizlab.bsky.social @meissnerlab.bsky.social show that #Toxoplasma gondii tepsin interacts with the AP4 adaptor complex & #clathrin to mediate #actin- and #myosin F–dependent vesicle trafficking from the trans-#Golgi to the parasite’s #lysosome-like PLVAC rupress.org/jcb/article/...

13.10.2025 20:15 — 👍 2    🔁 2    💬 1    📌 0
Postdoctoral researcher (m/f/x)

Sorry, here is the working link: job-portal.lmu.de/jobposting/2...

08.08.2025 08:34 — 👍 0    🔁 1    💬 0    📌 0

Hi there! Our group at LMU Munich is hiring a postdoc to work on Toxoplasma and Plasmodium.
Start: from Oct 1, 2025 | Location: Munich, Germany
1-year contract with extension possible
Apply by Aug 31: bit.ly/LMUpostdoc
Contact: elena.jimenez@lmu.de

08.08.2025 06:40 — 👍 6    🔁 5    💬 1    📌 0
Preview
Malaria-Wirkstoff aus Deutschland ein Durchbruch? Deutsche Wissenschaftler haben einen vielversprechenden Wirkstoff gegen Malaria entwickelt. Doch die politischen Entwicklungen in den USA bedrohen ihre Arbeit. Von Frank Bäumer.

Exciting news from our department! Prof. Markus Meißner @meissnerlab.bsky.social and Prof. Gernot Längst teams made headlines with a breakthrough malaria drug, advancing the fight against this deadly disease. #Malaria #Research #WorldMalariaDay
#Malaria #Research #Innovation #WorldMalariaDay

25.04.2025 11:00 — 👍 7    🔁 0    💬 0    📌 1

It was great to celebrate together with @meissnerlab.bsky.social and the Gras Lab!

17.12.2024 16:50 — 👍 0    🔁 0    💬 1    📌 0
Post image

Nothing like some festive cheer to wrap up the year! 🎄✨ The lab had a fantastic time at the Christmas market in Munich—great company, cozy vibes, and lots of Glühwein!

Wishing everyone a joyful holiday season! 🎅❄️

17.12.2024 16:41 — 👍 5    🔁 1    💬 1    📌 0
Post image

Our new banners have arrived! 😍 Keep your eyes open for them so you don't miss any EXIT sessions at conferences!
#microbiology #parasitology #lifesciences #molecularbiology

11.12.2024 12:31 — 👍 5    🔁 1    💬 0    📌 0

EastBio funded PhD opportunities in Edinburgh. Get in touch if you are interested in parasites and signalling.

11.12.2024 09:50 — 👍 7    🔁 8    💬 0    📌 0

🌟 Welcome to the official account of the Jiménez Lab! 🌟 We are passionate about parasitology. Our primary focus is on understanding non-histone methylation in T.gondii.
Follow us for updates on our work, publications and more! 🚀
#Parasitology #ResearchLab #MolecularBiology #Methylation #Toxoplasma

17.11.2024 08:19 — 👍 6    🔁 3    💬 0    📌 0