Gary Patti

Gut microbiota protect against hepatic steatosis by degrading sorbitol derived from dietary glucose @gjpattij.bsky.social
www.science.org/doi/10.1126/...

6/ So what can you do?
✔️ Choose supplements that are third-party tested for heavy metals (USP, NSF, or Informed Sport).
✔️ Prioritize whole-food protein sources when possible.
✔️ Advocate for stronger supplement regulation as the industry has little oversight.

Congratulations — excellent work!

Machine-learning-guided discovery of SLC25A45 as a mediator of mitochondrial methylated amino acid import and carnitine synthesis Khan et al. apply machine learning to identify substrates of UNC93A, SLC45A4, and SLC25A45. Biochemical assays and in vivo metabolite tracing establish SLC25A45 as a key mediator of mitochondrial impo...

Excited to share our work on discovery of SLC25A45 as a mediator of mitochondrial methylated amino acid import and carnitine biosynthesis. @cp-cellmetabolism.bsky.social www.cell.com/cell-metabol...

Huge thanks to you and the Skyline team for all that you do to support this amazing platform! It was an honor to showcase some of its capabilities.

Thanks so much. I think there’s a fine line between communicating the potential risks of exposures without causing panic that paralyzes life activities.

1/ RFK Jr.’s promised autism “report” landed this week. Instead of new science, we got headlines, a press conference, and far-reaching claims drawn from decades of existing research. Parents and pregnant people were left with overwhelming anxiety. Here’s what the evidence actually says 👇

The Washington Post did a great job of summarizing a complex topic. There is still so much to learn about the connections between the exposome and cancer. Thanks for including me.

Research in Scientific Reports suggests that blue-throated macaws can learn new actions by watching other macaws interact. The study indicates that this approach to learning is not exclusive to humans. go.nature.com/4g8p43m 🧪

Pretty impressive to be able to see mitochondrial dysfunction with the naked eye.

defunding children's brain cancer research. @endpts.com

a man in a shirt and tie is touching his forehead ALT: a man in a shirt and tie is touching his forehead

I have a first serious attempt to estimate the consequences of multi-year funding for July.

For new R01s, the amount of additional expenditure was

$135 M

The number of additional R01s that could have been funded is

182

1/9

Here are some of the highlights of the appropriations bill that the Senate appropriations committee just approved:

$48.7 billion for NIH, an increase of $400 million

Rejects the proposal to cap
indirect cost rates at 15%

Includes a provision to prevent MYF that would reduce the number of grants

Odds of winning NIH grants plummet as new funding policy and spending delays bite Funding multiyear grants up front will sharply cut number of investigators receiving awards

Even with flat funding for the NIH, under the current FY26 plan, there will be 60% less cancer research and much less research funded overall. We need to make sure Congress understands these tricks and protects against them in their budget plan.

1/ Since January, over 5,500 NIH-funded projects have been paused. That includes cancer trials, Alzheimer’s research, maternal health studies. This is work that directly impacts our lives.
And people aren't talking about it enough.
Let’s fix that 🧵

Or maybe the real goal is to decrease submissions so that they’re commensurate with reduced NIH staffing.

Huge congrats!!

Alan Marshall: A scientist and a Gentleman - MagLab Meet one of the greatest innovators in the history of mass spectrometry, hard at work.

RIP Alan Marshall, one of the greatest mass spectrometrists ever, and a great human to boot.

nationalmaglab.org/careers/meet...

Join ‪‪@drwendieberg.bsky.social‬ for this half hour of discussion of supplemental breast cancer screening for women with dense breast tissue.

"Gold standard science"

So sorry to hear that your award was canceled.

[Person with ponytail wearing lab coat hands balloon to another person in front of a springboard, a magnet hanging from above, and then a target] PERSON WITH PONYTAIL to Person 2: Rub this balloon against your head, then go jump past that magnet toward the target on the wall. [caption] Before the bathroom scale was invented, the only way to weigh people was mass spectrometry.

Mass Spec

xkcd.com/3094/

Here’s what we have going on at #ASMS2025

A strong statement about the importance of NIH on @cbsnews.com.web.brid.gy Sunday Morning

(Part 1)

Americans Don’t Eat Enough Fiber. Here’s Why That Worries Nutrition Experts The latest science suggests our fiber-poor diets trigger inflammation and contribute to a range of related diseases.

"Protein may be hot, but it’s fiber that Americans need to eat a lot more of."
"To get the full health benefits of fiber, it’s important to eat a variety of naturally fiber-rich foods and not rely on supplements...could actually lead to health problems..."
gift link www.wsj.com/health/welln...

Senate Democrats Host Forum on HHS: Day 2 YouTube video by Senator Peter Welch

Video from the hearing yesterday

www.youtube.com/live/_Szx0jJ...

Another good use of 5 minutes of your time.

I have previously posted about the slow issuance of NIH award in fiscal year 2025 compared to fiscal year 2024.

jeremymberg.github.io/jeremyberg.g...

These data were across all of the institutes and centers at NIH.

The results can be examined for each institute and center.

1/n

The Sable Award lecture at METPHYS2025 was really remarkable!

Tremendous congratulations to this years exceptional member of our community Kivanc Birsoy

Deaths from heart disease down 75%, that’s NIH.

Deaths from stroke down 75%, that’s NIH.

HIV/AIDS no longer a death sentence, that’s NIH.

99% of FDA approved drugs in the last decade, that’s NIH.

Please show this video to anyone who doesn’t understand why the NIH is so important.