Ryan T Scott

Machine Learning Ensemble Reveals Distinct Molecular Pathways of Retinal Damage in Spaceflown Mice https://www.biorxiv.org/content/10.64898/2026.01.22.701181v1

Biofilms: from the cradle of life to life support npj Biofilms and Microbiomes - Biofilms: from the cradle of life to life support

We have just published “Biofilms: from the cradle of life to life support” in @natureportfolio.nature.com #Biofilms & #Microbiomes. It highlights how #bioinformatics and #microbiology come together to study biological systems & food-associated biofilms. Stellar multidisciplinary team! rdcu.be/e0esg

NASA science data and software highlights for December! This includes a new repository for Aura software, THEMIS and SphereX and life sciences data, and new tools at the Exoplanet archive.

#NASA #OpenScience #OpenSourceSoftware

science.data.nasa.gov/features-eve...

a man is sitting at a table with a stick in his hand ALT: a man is sitting at a table with a stick in his hand

Just me, formatting manuscript references by hand. As God intended

Astronomers Detect a Signature of Life on a Distant Planet (Gift Article) Further studies are needed to determine whether K2-18b, which orbits a star 120 light-years away, is inhabited, or even habitable.

120 light years from Earth, there's a planet that may be covered in a living ocean. Here's my story on a tantalizing hint of life beyond the Solar System. Gift link: nyti.ms/3GbrEaZ 🧪

As I sit here about to peer review (my 2nd) “overdue” article on Friday at 10:30p, I realize you are 💯 correct

Replying so u both see (I’m also interested which labs involved 🤗) - here are 🚀 C Elegans datasets you may find of use (or the repo you’d hopefully submit data to 🎉)
🔗 repo osdr.nasa.gov/bio/repo/sea...
🔗about the repo doi.org/10.1093/nar/...
🔗repo tutorials osdr-tutorials.readthedocs.io/en/latest/

C. elegans. They wiggle to space. They wiggle back down. And sometimes

Glad to appear in @cnn.com talking about #drugdiscovery specifically our collaboration with @elonverse.bsky.social on accelerated drug discovery. We also show some (unrelated) @accelerationc.bsky.social @thematterlab.bsky.social robots that we used to do materials on the same video.

Foundational Architecture Enabling Federated Learning for Training Space Biomedical Machine Learning Models between the International Space Station and Earth

Figure 1

Figure 2

Figure 3

Foundational Architecture Enabling Federated Learning for Training Space Biomedical Machine Learning Models between the International Space Station and Earth [new]

So grateful to have this pre-print out 🎉

doi.org/10.1101/2025...

Foundational Architecture Enabling Federated Learning for Training Space Biomedical Machine Learning Models between the International Space Station and Earth https://www.biorxiv.org/content/10.1101/2025.01.14.633017v1

Thrilled to share our pre-print on 1st Federated Learning model deployed between Earth & @Space_Station 🚀 Huge thanks to HPE (SpaceBorne Computer), Intel (OpenFL), & NASA via the NASA Open Science Data Repository. Let’s build & move the ball forward! 🌅
🔗 doi.org/10.1101/2025...

Launch window opens tonight (1/12) 1am ET, 10pm PT (1/11). So thrilled for this!!! 🎉🚀🌌 First ever launch of New Glenn 🌅

Our postdoc Julien Cicero just sent me this beautiful image of IPSC derived motor neurons and I had to share 😍😍😍

A genomics learning framework for undergraduates Genomics is an increasingly important part of biology research. However, educating undergraduates in genomics is not yet a standard part of life sciences curricula. We believe this is, in part, due to...

🧬📝🚨 Out today: A genomics learning framework for undergraduates

We hope this will be one more tool to help integrate genomics into undergraduate education by supporting evidence-based curriculum design with a set of standardized concepts.

journals.plos.org/plosone/arti...

Schematic overview of the ENCODE 4 project's framework for identifying and classifying candidate cis-regulatory elements (cCREs). The process begins by defining regulatory anchors, such as DNase hypersensitive sites (rDHSs) and transcription factor (TF) clusters, which are filtered and classified using histone marks and other features. Elements are classified into functional categories, including promoters, proximal and distal enhancers, and CTCF-bound sites. The resulting registry includes millions of cCREs for human (GRCh38) and mouse (mm10), depicted alongside their classifications. Additional annotations, such as transcription activity, chromatin structure, genetic variation, and sequence motifs, are integrated for functional characterization. Image modified from https://www.biorxiv.org/content/10.1101/2024.12.26.629296v1.full

Now available as preprint:

The ENCODE 4 expanded registry of regulatory elements
- 2.35M 🧍 human cCREs
- 927k 🐭 mouse cCREs

www.biorxiv.org/content/10.1...

Led by @moorejille.bsky.social, this preprint summarizes data and analyses generated by hundreds of contributors across ENCODE 4

Congrats are overdue to Suni Willaims, who 3 days ago, became the 2nd most experienced US astronaut!

Space exploration and risk of Parkinson’s disease: a perspective review - npj Microgravity npj Microgravity - Space exploration and risk of Parkinson’s disease: a perspective review

🧠🚀Could space exploration increase the risk of Parkinson's Disease (PD)? Dr. Nilufar Ali led our perspective in npj Microgravity exploring parallels between spaceflight stressors and PD-like changes, from mitochondrial dysfunction to altered dopamine pathways.
www.nature.com/articles/s41...

HNY from Santa Cruz 🎉

A timeline titled "The Golden Age of Antibiotics" shows when each antibiotic drug class was first available for medical use, with example antibiotics labeled. Classes are color-coded by their source: actinomycetes, other bacteria, fungi, or synthetic. Milestones include the first antibiotics (arsphenamines in 1910), as well as the discovery of many actinomycetes-derived antibiotics, such as streptomycin, and sulfonamides, penicillins, and tetracyclines. Data: Hutchings, Truman, Wilkinson (2019). Created by Saloni Dattani for Our World in Data.

Many people talk about the "Golden Age of Antibiotics", but I hadn't seen it visualized properly.

Just how many types of antibiotics were discovered during that time?

So, I visualized it myself!

In honor of all the new arrivals, I'm sharing one of my favorite videos.

It shows 24 hours of Earth's rotation, with the camera locked to the sky instead of the ground. We're all hanging out on this spinning rock.

Brilliant work by Bartosz Wojczyński. 🧪

artuniverse.eu/gallery/1907...

I’ve been working with rangers at @officialnps.bsky.social for almost 20 years now promoting #darksky and science outreach in the parks. www.spacearttravelbureau.com

These colorful views of Saturn show data from multiple filters, mapped on colors perceptible to the human eye. Each filter combination emphasizes differences in the planet's cloud altitude or composition. Top left: green planet with lavender rings; top center: yellow planet with pale blue rings; top right: blue planet with orange rings; bottom left: purple planet with bright green rings; bottom center: blue planet with pumpkin rings; bottom right: lavender planet with pale olive rings. Saturn takes more than 29 years to orbit the Sun, and its seasons last about seven Earth-years. So far, Hubble has tracked slight changes in Saturn's year-to-year color, possibly caused by cloud height and winds. These observed changes are subtle because OPAL has covered only a fraction of a Saturnian year to date. Image credit: NASA, ESA, Amy Simon (NASA-GSFC), Michael H. Wong (UC Berkeley); Image Processing: Joseph DePasquale (STScI)

Hubble 🔭views of Saturn 🪐: each filter combination emphasizes differences in the planet's cloud altitude or composition. Hubble checks in on Saturn and the other giant planets as part of the Outer Planet Atmospheres Legacy (OPAL) program, which celebrated 10 years this month! go.nasa.gov/3VXposZ

Brushing up on my cardiology (am a computational biologist) and it’s oddly uncommon to see the electrics overlaid with the plumbing so to speak… here’s one of the clearest I’ve seen. From Braunwald’s Heart Disease.

Here are some other data also on radiation, then also O2, RH, Temp, tied to specific missions/experiments:
🔗RadLab visualization.osdr.nasa.gov/radlab/gui/o...
🔗EnvDataApp visualization.osdr.nasa.gov/eda/
🔗Open Science Data Repo osdr.nasa.gov/bio/repo/
🔗OSDR pub doi.org/10.1093/nar/...

Spatial omics of human arteries to understand what drives atherosclerosis: highlights role of the microvasculature (vasa vasorum), adventitial inflammation, migration of vascular smooth muscle cells (and more)
nature.com/articles/s44...

Funding to develop a “Data Sharing Index” (S-Index) via the NIH. Initial funding for six phase 1 winners, then Phase 2 finalists prizes are $500k (first), $300k (second), 100k (third) 🎉

🔗https://www.freelancer.com/contest/NIH-Data-Sharing-Index-Sindex-Challenge-2470942/prize-details

Large language models meet physics -- that's the promise of the open source "Genesis" project… the gs.generate() not released yet but the demos OMG I can't wait to use this for visualisation of concepts

genesis-world.readthedocs.io/en/latest/in...