Takashi Fukaya

Become our colleague at @fmiscience.bsky.social! The FMI is a very special place to start your lab: a vibrant international institute with world-class research groups and facilities, core funding, fantastic trainees, great colleagues😅, and a collegial culture. Get in touch if you're interested!

Thanks Ito-san @itok10918.bsky.social for the great tour of New York!!

Fun visit to Rockefeller after the CSHL transcription meeting. It was great to catch up with Bob Roeder since his visit to Japan for the Kyoto Prize!

Japan requires name change after marriage — with big effects on female scientists Nature - Survey finds law requiring married couples to share the same family name causes havoc for researchers.

Japan is the only country in the world that legally requires married couples to share the same family name

https://go.nature.com/4lfbXPL

Delighted to share a new review paper from the lab. We summarized/discussed recent key findings in enhancer biology. Thanks Dan Larson and @tinekelenstra.bsky.social for this opportunity!!

www.sciencedirect.com/journal/jour...

A dream come true: my first first-author publication! 🧬 🎉 Working to unravel the mysteries of long-range gene regulation has been an incredible journey. Endless gratitude to Evgeny, the lab, and all of the amazing collaborators who helped make this happen 🙌

Looks like I’m going to miss my flight from Frankfurt to Tokyo because of a delay at Basel airport🥺

Thanks Luca @lucagiorgetti.bsky.social for hosting me at FMI. It was absolutely a fun visit and I got many nice feedback!

Giving a seminar at FMI Basel tomorrow! Looking forward to it!!

Curious about epigenetics, gene regulation, and developmental biology?
Apply for the PhD position in Mannervik lab at Stockholm University!
We use single-cell genomics and genetic approaches to uncover how cells acquire their identities during development. Explore the chromatin landscape with us!

Look forward to visiting University of Lausanne next week!

Pachypodium gracilius has finally bloomed with yellow flowers after seven years of growing it from seed.

パキポディウム グラキリス、種から育てて7年、黄色い花が咲きました。

Delighted to share a new preprint from the lab!

We identified zinc-finger associated domain (ZAD)-containing C2H2 zinc-finger proteins (ZAD-ZnFs) as insulator-binding proteins in Drosophila.
www.biorxiv.org/content/10.1...

YouTube video by Johan Gibcus Rules of Engagement

Earnshaw, Goloborodko, Dekker & Mirny labs are excited to present our latest work, "Rules of engagement for condensins and cohesins guide mitotic chromosome formation" - now accepted!!
www.science.org/doi/10.1126/...
A short clip describing the key results:
www.youtube.com/watch?v=pmvO...

Nice to catch up with Luca @lucagiorgetti.bsky.social in Tokyo!

So excited to host my friend and former labmate @laghalab.bsky.social as a ... (drumroll) Special Guest at our institute! Mark your calendars and expect a great talk with beautiful live imaging.

Only one week left to submit your abstract to the @embo.org workshop on "Enhancer mechanics and Enhanceropathies". Submit now and present your latest work in one of our short talks.

It was great to see my long-time friend from graduate school, Takashi Akera
@takashiakeralab.bsky.social

Do you have an exciting story about #enhancers or #enhanceropathies?. Then submit your abstract to the @embo.org workshop on "Enhancer mechanics and Enhanceropathies" in Denmark before is too late: the deadline for abstract submissions is in two weeks (March 17th)!

meetings.embo.org/event/25-enh...

Chromosomal domain formation by archaeal SMC, a roadblock protein, and DNA structure - Nature Communications Eukaryotic chromosomes are organized into arrays of compact domain structures called TADs. Here the authors show that a member of the Archaea, the prokaryotic domain closest to the Eukarya, uses a euk...

Excited to share our work on archaeal 3D genome! This paper revealed how an archaeal SMC complex sculpts TAD-like domains by cooperating with a roadblock NAP and physical properties of DNA. Many congrats to our talented PhD student Kodai!
www.nature.com/articles/s41...

Making intrabodies from antibodies just got easier! Learn how we made 𝟭𝟵 intrabodies to bind and light up peptides and histone modifications in live cells. And thanks to Academia, all sequences are freely available. (video credit: Yuko Sato @YukoSatoT2) (1/15)
www.biorxiv.org/content/10.1...

1/n Excited to share our new preprint! Using live imaging in Drosophila embryos, we show that RNA Pol II clusters switch from sites of initiation to elongation during zygotic genome activation and that they are stably associated with an active gene: www.biorxiv.org/content/10.1...

Looking forward to it!! Abstract submission deadline: 17 March 2025.

Postdoctoral Researcher in chromosome organization and function Do you want to contribute to top quality medical research? Join the lab of Camilla Björkegren at the Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden, to study molec

Job alert: My collaborator, Camilla Björkegren at Karolinska Institutet, is looking for a postdoc to study the mechanisms of chromosome organization!
ki.varbi.com/en/what:job/...

Transcription near arrested DNA replication forks triggers ribosomal DNA copy number changes Abstract. DNA copy number changes via chromosomal rearrangements or the production of extrachromosomal circular DNA. Here, we demonstrate that the histone

Hello Bluesky. For my first post here, I am happy to share that our paper is finally out in Nucleic Acids Research, highlighting how collision between transcription machinery and arrested replication fork triggers circular rDNA formation in budding yeast.

academic.oup.com/nar/article/...

Very excited to share our paper on Gene and Transposable Element expression in mammalian preimplantation development, online today! www.cell.com/cell/fulltex...
A short thread to highlight some of our findings 🧵

A high-protein diet-responsive gut hormone regulates behavioral and metabolic optimization in Drosophila melanogaster - Nature Communications Organisms regulate their feeding behavior to prevent overconsumption of certain nutrients. Here, the authors identify the importance of gut hormones in suppressing protein overfeeding.

Excited to see our new gut hormone paper in @naturecomms.bsky.social in collaboration with our alumnus Dr. Yuto Yoshinari (Gunma Univ.) and others!
A high-protein diet-responsive gut hormone regulates behavioral and metabolic optimization in Drosophila melanogaster.
www.nature.com/articles/s41...

Have you ever wanted to *see* receptor activity in embryos? If so, our new preprint is for you! In it, we showcase a new live-cell biosensor for visualizing receptor tyrosine kinase activity in living embryos – pYtags!

www.biorxiv.org/content/10.1...

Are you interested in studying enhancer biology/3D genome organization in my lab at the University of Tokyo? This Biohub Network program would be a great opportunity for you! Feel free to reach out if you're interested!!
www.czbiohub.org/program-ssfc...

ZNF143 is a transcriptional regulator of nuclear-encoded mitochondrial genes that acts independently of looping and CTCF ZNF143 has been implicated in gene activation and chromatin looping. Magnitov et al. show that ZNF143 has no general looping factor activity and explain why this function has been misattributed. Instead, ZNF143 regulates transcription of nuclear-encoded mitochondrial genes, ensuring energy homeostasis, proliferation, and differentiation potential of stem cells.

Please check out our new paper showing that the supposed looping factor ZNF143 has no role in chromatin looping: www.cell.com/molecular-ce...

And also check out the companion paper from @andersshansen.bsky.social: www.cell.com/molecular-ce...