Jalil Rasgado Toledo

The effect of chronic stress and chronic alcohol intake on behavior, brain volume, and functional connectivity in a longitudinal rat model Rasgado-Toledo, et al. reported sex-dependent and region-specific effects of combined ethanol exposure and chronic stress on both the rat brain volume and

New paper by @jalilrt.bsky.social , @egarza.bsky.social and friends. "The effect of chronic stress and chronic alcohol intake on behavior, brain volume, and functional connectivity in a longitudinal rat model". doi.org/10.1093/brai...

Come to Querétaro!, we have tacos and science

This pipeline saved my PhD

The result of a large (42 authors!) collaboration:
"Go Figure: Transparency in neuroscience images preserves context and clarifies interpretation"
arxiv.org/abs/2504.07824
TL;DR: The FMRI world can (and should) improve results interpretation and reproducibility *today*, via transparent thresholding.

this happened today and this felt so good. Thanks @mallarchak.bsky.social and team!

Examining Alzheimer's Disease Modifiable Risk Factors: Impact of Physical Activity and Diet on Neuroanatomy and Behaviour in Mice Dementia, a global public health challenge, is significantly influenced by lifestyle factors such as obesity. This study examines the impact of obesity and intervention approaches -physical exercise, ...

New preprint by Cindy Lucero and Chloe Anastassiadis examining modifiable dementia risk factors (exercise and diet) in a mouse model of Alzheimer’s

www.biorxiv.org/content/10.1...

Morphine self-administration induces region-specific brain volume changes and microglial phenotypic alterations without affecting neuronal density in male Wistar rats Addiction to opioids, including morphine, is a major public health crisis in the U.S. It has been associated with brain volume changes in reward-related regions, neuronal death, and neuroinflammation....

New preprint from the lab: www.biorxiv.org/content/10.1...
This was led by former Bachelor student Débora Elizarrarás and postdoc César Carranza. Here we wanted to study structural brain changes in opiod self-administration. Specifically if there was a link between MRI volume and neuroinflamation.

The project I have been working on for 4 years. I stressed myself in the same way I stressed my rats, but at least they didn't become alcoholics.

My advice of the day: it may seem like a good idea to consume alcohol when stressed, but it's not

fMRI data acquisition and analysis for task-free, anesthetized rats - Nature Protocols We present an fMRI acquisition protocol for anesthetized rats, suitable for various scanners and field strengths, which includes animal handling, MRI sequence parameters, data conversion, preprocessin...

fMRI data acquisition and analysis for task-free, anesthetized rats

www.nature.com/articles/s41...

Three must read papers for PhD students. #scisky #PhD #science #research #academicsky

1. The importance of stupidity in scientific research

Open Access
journals.biologists.com/jcs/article/...

I'm already missing the snow and the lab, but here, I have real tacos, the perfect balance

The entire team behind the amazing scientific research at the cerebral imaging centre. Thanks to @mallarchak.bsky.social for hosting me during these months, and to @egarza.bsky.social to make it possible. I can't summarize everything I learned and the wonderful people I met during my stay. Thanks!!