Omkar Joshi

Restoring the tumour mechanophenotype of vocal fold cancer reverts its malignant properties - Nature Materials Vocal fold cancer tumours lose some of their malignant traits when mechanically stimulated by physiological stretch or vibrations, mimicking the opening and closing of vocal folds and phonation.

What music should we play to our cells? This was the start of an amazing journey from @ivaskalab.bsky.social at @turkubioscience.bsky.social with Jasmin Kaivola and collaborators @sarawickstrom.bsky.social and others to explore larynx cancer mechanosensitivity!

www.nature.com/articles/s41...

Happy to share our new review! Check it out and comments are welcome 😊: tinyurl.com/bdh6zzzp

CELL MIGRATION LAB We study cell migration in health and disease

🚨 We are hiring TWO postdocs to join the Cell Migration Lab (cellmig.org) 🇫🇮 as part of the new Centre of Excellence in Immune–Endothelial Interfaces (IMMENs).
Join us to decode immune regulation & develop next-gen imaging tools! 🧪🔬
Details in thread 🧵👇
#ScienceSky #Postdoc #AcademicJobs Please RT🫶

I am looking for two postdocs to join our lab
- One (bio)image analyst
- One cell biologist interested to work on lymphatics!

The positions will open soon, be in touch!

Attending the @ascbiology.bsky.social Cell Bio 2025 this week! I'll present a poster tomorrow (Dec 7) from 2:15PM to 3:45PM on Board No. 209 describing my work on bidirectional regulation between mitochondria and focal adhesions in @johannaivaska.bsky.social's @ivaskalab.bsky.social!
Come say hi :)

EACR Board members and other key opinion leaders author regular EACR Viewpoint articles for publication in our affiliated journal @moloncology.bsky.social 🧠

Catch up with all the EACR Viewpoints published to date: febs.onlinelibrary.wiley.com/doi/toc/10.1...

The actin cortex acts as a mechanical memory of morphology in confined migrating cells - Nature Physics Cells often navigate through confined spaces. Now it is shown that cells retain a mechanical memory of previous confinement events, which makes them more efficient at migrating through narrow microenv...

Excited to share our new publication in Nature Physics about the mechanical memory of morphology in confined migrating cells by @kyohalie.bsky.social 🥳

Super fun collab with @davidbrueckner.bsky.social and @gcharras.bsky.social 👏🏻

Enjoy the reading www.nature.com/articles/s41...

a bunch of balloons are flying in the sky . ALT: a bunch of balloons are flying in the sky .

I have some BIG NEWS to share today!

Today I begin my next adventure as

Chief Editor of Nature Biomedical Engineering!!

(a thread) @natmethods.nature.com @natbiomedeng.nature.com @natureportfolio.nature.com

I'm so sorry. Could you confirm if the heating is switched on 😉

Wow

Are you looking for a postdoc?
I will be looking for 2-4 people after the summer to join the lab !!
Do not hesitate to reach out and disseminate !!

1/ Beyond thrilled to see my #PhD work now published in @jcb.org
A short thread (🧵) for #metastasis #metabolism #ExtracellularVesicles (EVs) aficionados

@gounismichalis.bsky.social‬ et al. show that cells that seed early lung #metastasis in #BreastCancer have altered #metabolism. These metabolic alterations lead them to release extracellular vesicles which engender a microenvironment conducive to invasive growth. rupress.org/jcb/article/...

Dynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cells - Nature Cell Biology Conway et al. show that integrin β1 phosphorylation is regulated through balanced activities of tyrosine kinases, such as Src and Arg, and phosphatases, such as PTP-PEST and Shp2, facilitating invadop...

Latest from @ivaskalab.bsky.social @jrwconway.bsky.social in NCB. We find that SHP-2 inhibition stops TNBC invasion and limits metastasis by blocking integrin dephosphorylation!

Read more at:

www.nature.com/articles/s41...

New paper from @ivaskalab.bsky.social out now! 🍾 Watch how cancer cell adhesion dynamics are disrupted by inhibiting the phosphatase Shp2 - key to integrin β1 phosphorylation. Blocking Shp2 impairs adhesion and reduces invasion potential. 🎥👇 Read more at: www.nature.com/articles/s41...

Our newest paper is out in NCB. @jrwconway.bsky.social‬ designed a new FRET reporter, Illusia, to show the importance of integrin β1 phosphorylation dynamics in 3D invasion! Video: TNBC cells expressing Illusia with a Src (Saracatinib) or SHP2 (SHP099) inhibitor. www.nature.com/articles/s41...

Amazing news! Warm congratulations to @johannaivaska.bsky.social for the award. Super proud!

www.utu.fi/en/news/news...

Collagen content of the human omentum and human omental HGSOC metastasis.

📣 Pre-print alert: Excited to have collaborated with Pam Kreeger and Kristyn Masters on this study showing that fibronectin composition and transglutaminase 2 crosslinking cooperatively regulate ovarian cancer cell adhesion in ECM-mimetic constructs.
www.biorxiv.org/content/10.1...

Adhesion-derived condensates control component availability to regulate adhesion dynamics Integrin adhesion complexes mediate cell-extracellular matrix (ECM) interactions and undergo dynamic remodelling to regulate cell adhesion and migration. Here, we demonstrate that tensin 1 (TNS1), a m...

New preprint alert!📣 @midibu.bsky.social and team take a deep dive into Tensin1 liquid-liquid phase separation (LLPS) and the mechanisms of how it regulates adhesion dynamics!
Check out the preprint here: www.biorxiv.org/content/10.1...
@johannaivaska.bsky.social

Adhesion-derived condensates control component availability to regulate adhesion dynamics Integrin adhesion complexes mediate cell-extracellular matrix (ECM) interactions and undergo dynamic remodelling to regulate cell adhesion and migration. Here, we demonstrate that tensin 1 (TNS1), a m...

Happy to share our Tensin 1 phase separation project is now on bioRxiv.
www.biorxiv.org/content/10.1...

This wouldn't be possible without
@johannaivaska.bsky.social
@ivaskalab.bsky.social
#VattulainenLab
#MSCA by @ec.europa.eu
@turkubioscience.bsky.social
@inflames-flagship.bsky.social

I'm at the Fibronectin GRC till the end of the week! Come say hi and I'll tell you a bit about mitochondrial near focal adhesions😉

A reminder to colleagues interested in Cell-Matrix adhesion & anything ECM related that registration is now open for the Fibronectin, Integrins & related molecules Gordon Research Conference. Incredible list speakers! incredible location! it will 🔥 🔥 🔥 Please join us! www.grc.org/fibronectin-...

Grateful for the opportunity to participate in this Viewpoint with @follainga.bsky.social , @omkarjoshi.bsky.social and @guijacquemet.bsky.social :
Time, the final frontier
doi.org/10.1002/1878...

We wrote a small Viewpoint for Molecular Oncology with
@follainga.bsky.social

@omkarjoshi.bsky.social

Michal Dibus

via EACR
@helloeacr.bsky.social

Time, the final frontier
febs.onlinelibrary.wiley.com/doi/full/10....

Hope you find it interesting

In Memoriam: Wolfenson, Giannone, and Schwartz recall the life and many contributions of Michael Sheetz, who passed away on January 30, 2025. rupress.org/jcb/article/...

If you are planning your conferences for the year- keep an eye out for EACR’s Goodbye Flat Biology! Essen 23-25 Sept 2025
www.eacr.org/conference/goodbyeflatbiology2025

#CancerResearch #Oncology I’ll see you there. :)
@helloeacr.bsky.social

We are looking for a doctoral candidate to join the lab! If you are interested in working with human breast tissue samples straight from the clinic and do not fear large data sets, this might just be your dream project ☺️ Apply now ⬇️
ats.talentadore.com/apply/vaitos...
📸 @oonapaavolainen.bsky.social

Thank you @focalplane.bsky.social for featuring my image!

🎉 Great success for Turku Bioscience Centre at the 3MT competition!

Congrats to Rahul Birdar (@lahesmaalab.bsky.social) for securing 2nd place and Omkar Joshi (@ivaskalab.bsky.social) for being selected to represent @utu.fi in the international 3MT competition by the SANORD network! 👏 #3MT #SANORD

Friends! The science that we love is under threat. World-wide, there're forces seeking to make it corporate-like, focused on deliverables, or even the enemy of society. Take a stand & celebrate science & music! #theconferencetoendallconferences - Registration starts NOW!
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