Tanmay Bharat

Grows quite slowly over months, maybe that’s why? Lots to study and much to learn…

An Asgard archaeon with internal membrane compartments

Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!

www.biorxiv.org/content/10.1...

It’s 3-fold…

Be our neighbour, please apply!

Cool!

Finally, someone has solved a real problem with AI! No more having to take a paper in the format for a journal that rejected you, and reformat it for a new journal. Well done!! formatmypaper.com

We have an open post-doc position in my group to study mRNA cleavage and polyadenylation using biochemical reconstitution and cryoEM.

Please get in touch if you are interested in joining this amazing team! 🔬🧬🤩
#RNA #cryoEM

It's deep when the GPU starts making a loud noise

The final version of our multispectral microscopy manuscript is now online at Nature Photonics: www.nature.com/articles/s41...

The main additions are some further comparisons to yet more unmixing algorithms, in which we find that our algorithm is still the most accurate.

Excited about our most recent collaboration with the Wong lab, lead by William Schmidt, describing a T4P and CdrA-mediated mechanism of sensing surface EPS. Fun stuff and great work William and team.
www.nature.com/articles/s41...

Sub-cellular chemical mapping in bacteria using correlated cryogenic electron and mass spectrometry imaging

Congrats Hannah Ochner and authors on this important paper! Strong collaboration with @kiranrpatil.bsky.social

www.biorxiv.org/cgi/content/...
@mrclmb.bsky.social @wellcometrust.bsky.social

Congrats!

Colin Kleanthous' fundraiser for Motor Neurone Disease Association Help Colin Kleanthous raise money to support Motor Neurone Disease Association

My wonderful colleage Colin Kleanthous is raising money for the MND association. Please support Colin in this worthy endeavor! www.justgiving.com/page/colin-k...
(Please repost!)

Cryo-EM structure of the vault from human brain reveals symmetry mismatch at its caps Lövestam and Scheres present a cryo-EM structure of vault particles, found during tau filament extraction from progressive supranuclear palsy (PSP) brain tissue. They reveal a symmetry shift at the va...

Sofia Lövestam's vault structure is now online in Structure @cellpress.bsky.social. 🥳

How beautifully explorative is #cryoEM! We never planned to do this. The vaults just came down with #amyloids from human brain tissue, and Sofia decided to have a closer look.

www.cell.com/structure/fu...

E. coli genome has been remade with 101,000 changes to its DNA The recoded bacterium uses only 57 of the 64 possible genetic codes, freeing up seven to be used for different purposes

#ICYMI, @newscientist.com spoke to Wes Robertson, Group Leader in the LMB’s PNAC Division, about the ‘gargantuan effort’ behind synthesising E. coli with just 57 codons:
www.newscientist.com/article/2490...
#LMBintheNews

Monoclonal antibodies revolutionized biomedical science and health care The story of the discovery of these molecules 50 years ago shows how the free exchange of ideas can lead to life-changing treatments.

The story of the discovery of monoclonal antibodies 50 years ago shows how the free exchange of ideas can lead to life-changing treatments

go.nature.com/45GeSM0

Excited to share our latest work with @simonbullock11.bsky.social! We looked at how diverse mRNAs get selected for subcellular localization and it turns out that a single protein can recognize different RNA elements using shared features that weren’t apparent before.
www.biorxiv.org/content/10.1...

Attendees of the recent bacteriorhopsin symposium, photographed from above.

Balsawood model of bacteriorhodopsin

Black and white photograph of Nigel Unwin and Richard Henderson sitting outside the LMB, 1991

Symposium attendees applauding in the LMB's Max Perutz Lecture Theatre.

The LMB recently hosted a symposium to mark 50 years since Richard Henderson and Nigel Unwin published the structure of bacteriorhodopsin, the first 3D structure of a protein determined by #cryoEM.

Read about the event and find more photos here: www2.mrc-lmb.cam.ac.uk/the-structur...

#LMBNews 🧪🔬

Good luck!

Highly recommend, speaking from experience!

We are excited to be a part of a collaboration lead by Tarafder and Bharat titled "Targeted disruption of phage liquid crystalline droplets abolishes antibiotic tolerance of bacterial biofilms" - this work has exciting implications for biofilm-targeted therapeutics.
www.biorxiv.org/content/10.1...

Great contributions by Miles Graham, Luke Davis, Shawna Pratt @janboehning.bsky.social, Pavi Manivannan, @zhexinwang.bsky.social, Camila Clemente and Ray Owens

Thanks to support from the @mrclmb.bsky.social @wellcometrust.bsky.social @thelisterinstitute.bsky.social

Biophysical basis of filamentous phage tactoid-mediated antibiotic tolerance in P. aeruginosa - Nature Communications Filamentous phages can assemble into mesoscale structures termed tactoids that protect bacteria in biofilms from antibiotics. Here, the authors dissect the biophysical factors influencing this protect...

and:

Biophysical basis of filamentous phage tactoid-mediated antibiotic tolerance in P. aeruginosa

doi.org/10.1038/s414...

Building on our previous work:

Phage liquid crystalline droplets form occlusive sheaths that encapsulate and protect infectious rod-shaped bacteria

doi.org/10.1073/pnas...

Targeted disruption of phage liquid crystalline droplets abolishes antibiotic tolerance of bacterial biofilms

led by @abultarafder.bsky.social

Great collaboration with @pearce-maths.bsky.social and @geiselbiofilm.bsky.social

www.biorxiv.org/cgi/content/...

AlphaFold developer Google DeepMind to fund CASP as NIH funding falls short Protein structure prediction contest CASP gets temporary funding from Google DeepMind as NIH grant runs out.

NEW from me at STAT:

We've learned that DeepMind is going to fund CASP, the protein structure competition that brought Google DeepMind's #AlphaFold to prominence (and a Nobel Prize), as its NIH funding runs out.

More @statnews.com:
www.statnews.com/2025/07/21/c...

🖥️🩺🧪🧬 #bioML

Another chance to join the amazing @mrclmb.bsky.social with its generous core funding that allows it scientists to perform world-leading science, and with the best research culture you'll have ever experienced! 🤩

Research Group Leader in Chemical/Synthetic Biology at MRC Laboratory of Molecular Biology Start your UK & international job search for academic jobs, research jobs, science jobs and managerial jobs in leading universities and top...

We are looking to recruit a tenure track group leader in the field of Chemical/Synthetic Biology (in the broadest sense) to lead a research program within the Division of Protein & Nucleic Acid Chemistry ( www.jobs.ac.uk/job/DNW809/r... ) at the MRC Laboratory of Molecular Biology (LMB).

It was an honor to be part of this celebration at the LMB. Richard and Nigel’s work on bacteriorhodopsin has inspired generations of structural biologists, and they have set an example of being especially friendly and helpful.

Highly collaborative efforts that involved 6 lab members and the labs of @yiliangding.bsky.social and @rdaslab.bsky.social. We uncovered a telomerase dimer and its potential role in telomere maintenance.