Cam-CAN

Another nice use of multiple cohorts, including Cam-CAN

Why do some people lose memory faster with age? A mega-analysis of 13 longitudinal datasets (3,700+ adults, 10,000+ MRIs) shows that memory decline tracks brain atrophy, especially in the hippocampus, and that these links strengthen with age, but not APOE status: www.nature.com/articles/s41...

We are excited to announce #COGNESTIC 2026 @mrccbu.bsky.social in Cambridge, between 14-25 Sep 2026. Our 2-week summer school provides training in state-of-the-art methods for open neuroimaging analysis and great opportunities for professional networking:
www.mrc-cbu.cam.ac.uk/events/cogne...

Sex differences in healthy brain aging are unlikely to explain higher Alzheimer’s disease prevalence in women | PNAS As Alzheimer’s disease (AD) is diagnosed more frequently in women, understanding the role of sex has become a key priority in AD research. However,...

Another interesting paper from LifeBrain consortium suggesting that sex differences in healthy brain aging are unlikely to explain higher prevalence of Alzheimer’s disease in women www.pnas.org/doi/10.1073/...

"CamCAN 15 years on" - a new preprint reviewing all findings about the cognitive neuroscience of ageing from sharing CamCAN data, led by @rhens.bsky.social : osf.io/preprints/ps...

Complementary MR measures of white matter and their relation to cardiovascular health and cognition - Scientific Reports Scientific Reports - Complementary MR measures of white matter and their relation to cardiovascular health and cognition

New CamCAN study led by @praykov.bsky.social used 11 different white matter (WM) measures to show that WM health is multidimensional: 4 latent MRI-derived factors explained 89% of WM variance, were predicted by vascular health, and predicted cognition: doi.org/10.1038/s415...

New CamCAN paper led by @noham-wolpe.bsky.social shows that older adults’ tendency to see facial expressions as more positive may not be the adaptive “rose-coloured glasses” we thought, but could signal early cognitive decline and neurodegeneration: pubmed.ncbi.nlm.nih.gov/40854689/

International study shows that higher levels of education do not reduce rates of cognitive and brain decline in later years, contrary to views that education protects against such decline: www.nature.com/articles/s41...
@rhens.bsky.social

Important result contradicting common view that more education protects against cognitive decline in old age (unfortunately)...

More fantastic work on the importance of pulse pressure from @kamentsve.bsky.social ...

Updated version of this paper now published in Cerebral Cortex 🥳 doi.org/10.1093/cerc...

@sarahhenderson.bsky.social is on a roll 🙌🏻

#PsychSciSky #neuroskyence #memory #aging

Nagrodzki et al. (@yacnag) examine attentional negativity bias in depression, linking slower processing of angry faces to increased activity in the insula, IFG, and parietal cortex. Findings suggest this bias may persist in remission: doi.org/10.1037/emo0... @APA_Journals

Temporal autocorrelation is predictive of age — out now!
www.pnas.org/doi/10.1073/...

We used @camcan-2010.bsky.social #MEG data and massive time-series feature extraction (hctsa) to understand which aspects of neural activity predict a person's age. #PNAS #aging #MEG #Neuroscience #Neuroskyence

Hello BlueSky - sorry it has taken us so long to move here from less-blue skies. Anyway please follow us if you're interested in healthy ageing of brain and cognition, including scientific outputs and news from the Cambridge Centre for Ageing and Neuroscience (www.cam-can.org).