Olson Lab

Check out our latest paper in Nature Neuroscience (rdcu.be/ey7yk). This was a great collaboration with some very surprising results! Seems that a glutamate burst and proximate IEG expression might not be necessary for structural neuroplasticity induced by 5-HT2A partial agonists.

I love all of our papers equally, but I might love this one a bit more. Rare to see complex molecule total synthesis, molecular neuroscience, and behavioral neuropharmacology in the same paper! Special thanks to all of of the students and our collaborators who helped make this work possible

Why it's hard to study the neuroscience of psychedelics : Short Wave Researchers are studying psychedelics as a possible treatment for conditions like depression, PTSD and substance use disorders. But they don't know exactly how these drugs work. Getting the answer to ...

Check out IPN Director @deolsonlab.bsky.social on NPR's Short Wave podcast. Part 1 gives an introduction to the breadth of psychedelic research and is out now. Stay tuned for part 3, where David discusses IPN research in more detail. Listen wherever you get your podcasts or at this link:

We’re excited to announce that @ucdavisipn.bsky.social has been accepted to compete in #STATMadness! A bracketed competition from @statnews.com to find the most innovative research institution in the country! Round one ends this weekend - vote now!

Learn more at www.statnews.com/feature/stat...

Could psychedelics be fine-tuned to relieve anxiety but skip the ‘trip’? Pinpointing neurons that mediate psychedelics' beneficial effects.

We wrote a short News & View piece to highlight the exciting work by Tina Kim and @deolsonlab.bsky.social at @ucdavisipn.bsky.social. Novel neuron-tagging techniques used to dissect the mechanism of psychedelics ⚡🧠🤯

www.nature.com/articles/d41...

Vote for UC Davis in STAT Madness!!!

I should have tagged @naturechemistry.bsky.social and @ucdavisipn.bsky.social

Efficient and modular synthesis of ibogaine and related alkaloids - Nature Chemistry Preliminary clinical trials suggest that ibogaine and its active metabolite noribogaine have powerful anti-addictive properties, Now, a strategy for the scalable, asymmetric total synthesis of ibogain...

Check out our ibogaine total synthesis in @NatureChemistry! This was a tough project that took nearly a decade to complete by @UCDavisIPN researchers.
Includes the synthesis of the unnatural enantiomer of ibogaine and ibogaine analogues that modulate SERT

www.nature.com/articles/s41...