Nikos Louros

TAF15 amyloids propagate via defined motifs in a prion-like fashion TATA-box binding protein-associated factor 15 (TAF15) is an RNA-binding member of the FET family recently identified as the primary fibrillar constituent in a subset of frontotemporal lobar degenerati...

🚀 Our new preprint is out!
We uncover that TAF15 forms amyloids that propagate in a prion-like manner via defined APR motifs.
• First TAF15 cell biosensor
• Prion-like TAF15 propagation
• Mapping TAF15 aggregation propensity
🔗 www.biorxiv.org/content/10.1...

Energetic profiling reveals thermodynamic principles underlying amyloid fibril maturation - Nature Communications Energetic profiling of cryo-EM time series for IAPP, tau, and α-synuclein reveals how amyloid fibril maturation is driven by sequence-encoded hotspots. Rearrangement of APRs anchors growth, while cofa...

🚨Thrilled our work is out in @NatureComm!🚨

Energetic profiling of >110 cryo-EM amyloid fibrils (IAPP, tau, α-syn) reveals how APRs + cofactors shape fibril maturation and disease-relevant polymorphs.

Read the full paper: doi.org/10.1038/s414...

Amyloid Explorer: a global atlas of amyloid fibril structures and thermodynamic principles Amyloid fibrils underpin both functional and pathological protein assemblies and exhibit extensive structural polymorphism. More than 600 high-resolution fibril structures are now available across ove...

🚨Preprint alert! 🚨
Proud to share Amyloid Explorer: a global atlas of amyloid fibril structures and thermodynamic principles. Huge thanks to our members of the lab, as well as the always great Joost Schymkowitz, Frederic Rousseau (VIB–KU Leuven).
www.biorxiv.org/content/10.1...

Toward a thermodynamic taxonomy of amyloid fibrils In this issue of Structure, Connor et al.1 combine topology and residue-level energetics of α-synuclein and tau fibrils to identify isoenergetic fold …

🚨Our work in Structure!🚨
Overview of the expanding toolkit for amyloid structures: from topology clustering to residue-level energetics & cofactor mapping. Conserved hotspots form isoenergetic folds, environment biases fold selection & shapes disease strains. www.sciencedirect.com/science/arti...

💬 I’m grateful for the help of an incredible team of collaborators, Senthil Kumar Thangaraj
@wagnerjessica.bsky.social

@rodrigoagallardo.bsky.social
Gabriele Orlando Matthias De Vleeschouwer Jillian Madine
@nlouros.bsky.social

@jonasneher.bsky.social

Medin drives Aβ40 to adopt Aβ42-like fibril polymorphs in vitro Medin, a vascular amyloid derived from MFG-E8, is the most prevalent form of localized human amyloid and co-localizes with Aβ in Alzheimer’s disease and, in particular, cerebral amyloid angiopathy (CA...

🚨New Preprint Alert🚨
Collaborative effort from my post‑doc days at @vib-switch-lab.bsky.social, so many brilliant colleagues came together to show how medin steers Aβ40 toward Aβ42‑like fibril polymorphs. Grateful to have played a part!
www.biorxiv.org/content/10.1... #amyloid #Alzheimers

Energetic profiling reveals thermodynamic principles underlying amyloid fibril maturation Amyloid fibrils adopt diverse structural polymorphs that underlie disease-specific phenotypes, but the thermodynamic principles guiding their formation and maturation remain poorly understood. Here, w...

🚨New lab preprint!🚨
Thermodynamic profiling of cryoEM fibrils shows that key stabilizing motifs shuffle during amyloid maturation, while cofactors ease structural frustration to let energetically optimal polymorphs emerge.
www.biorxiv.org/content/10.1...

Exciting News! We’re thrilled to announce the first Functional Amyloid Meeting at DESY!

Join us for a deep dive into the latest breakthroughs in functional fibrils, with a spotlight on amyloid molecular and cellular mechanisms and their biomedical applications.

landau-cssb.de/meeting-of-f...

Thanks! Took me a bit but made it!

Louros lab group photo in the CAND (2025)