New personal view article
The role of microbial genomics in delivering the UK’s national action plan for confronting antimicrobial resistance 2024–29
www.thelancet.com/journals/lan...
#IDSky #ClinMicro #AMR #OpenAccess #OA
04.03.2026 12:35 —
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Is de lobotomie een vereiste voor VVD lidmaatschap?
04.03.2026 09:58 —
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FEMS is saddened to learn of the recent passing of Prof. Jeff Cole, former Editor-in-Chief of FEMS Microbiology Letters. He was committed to advancing the field & supporting young scientists. His legacy will continue to shape the community he helped nurture: t.co/g9kxRhYniO
03.03.2026 16:40 —
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I am with you on the anti-AI front.
03.03.2026 21:06 —
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Epistasis and co-adaptation in bacterial genome evolution
Nature Reviews Genetics - Bacterial genome evolution is shaped by epistasis, which can constrain or promote specific evolutionary paths. The authors review how integrating the effects of epistatic...
I’ve spent a lot of time over the past two years thinking about genome evolution and how recent research revealing complex gene-gene interactions has complicated traditional ‘gene-centric’ genomic approaches to evolution. So here is a review that consolidates these thoughts!
rdcu.be/e6pHY
02.03.2026 15:48 —
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Lipsync battle tonight between students and lecturers. Great acts, my favourites were Thrift Shop and Proud Mary (the Tina T version). But all so well done!
#vetschool #surrey
03.03.2026 21:04 —
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Headshot of Jeff Cole
We were deeply saddened to learn of the death of Professor Jeff Cole, a long-standing member who held many positions in the Society. Jeff was elected an Honorary Member in 2011. You can read his full obituary here: microb.io/46xYzkz
03.03.2026 10:15 —
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Another catzilla poster
03.03.2026 00:32 —
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Catzilla movie poster
😂
03.03.2026 00:31 —
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😱😂
02.03.2026 23:21 —
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Meg is on repeat..
02.03.2026 22:44 —
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That is exactly what she does... 😁
02.03.2026 22:33 —
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She is horrendously affectionate the last few days, at the expense of my sleep.
02.03.2026 21:50 —
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Oh, it's International Rescue Cat Day! My three are all rescues but I also was a foster for an international cat rescue for ten years, so here are some of the cats I fostered
Some info in the alt texts
#catsofbluesky #cats
02.03.2026 21:26 —
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Rescue Meg accurately avoiding the shadow earlier today.
02.03.2026 21:40 —
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Followed by saying "please get a plumber and let us know the outcome". #thameswater takes zero responsibility.
02.03.2026 19:03 —
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Helldesk person "the meter reading stays the same, 1251. Meter is working fine, are your other appliances functional?"
AAAAARGH.
@infinitescream.bsky.social
02.03.2026 17:03 —
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I'm in helpdesk hell. Trying to show Thames Water there is a leak before the water enters my home, internal stop valve closed and the water meter keeps on increasing, but not gushingly, so only the digits after the whole m3 increasing (1251.177 to 1251.289 in less than 3h)
02.03.2026 17:03 —
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Had to go via a Thames Water Whatsapp AI chatbot today. I wanted to rip it a new arsehole within 2 minutes.
Utterly useless. Now waiting for the assigned human to respond...
02.03.2026 12:03 —
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"US says Iran’s ‘reckless’ attacks threaten regional stability"
Eh... no. US and Israel's reckless attacks threaten regional stability. I have no sympathy for the Iranian government, but it is the US and Israel that are the aggressors.
02.03.2026 11:57 —
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Manual device
02.03.2026 09:22 —
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My students may be helped by it as well...
01.03.2026 22:00 —
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The quickest way to stop any Iranian retaliation would be to stop bombing them.
Arresting the Trumpist idiots and Nethanayu clan for war crimes would help.
#duh
01.03.2026 21:59 —
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Corner of a lap mat padded mat with a fabric of red chilli's repeating all over the fabric.
Now available to buy, red chilli's lap mats.. craftysharp.etsy.com/listing/4360...
01.03.2026 20:04 —
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I switched the channelto Indycar,so bored.
01.03.2026 21:06 —
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Rapid and reliable diagnosis of mucormycosis using colorimetric loop-mediated isothermal amplification
ABSTRACTCurrent diagnostic approaches for mucormycosis are often limited by low sensitivity and prolonged turnaround times, which result in delayed treatment and poor clinical outcomes. We developed a novel diagnostic method utilizing a colorimetric loop-mediated isothermal amplification (LAMP) assay for the rapid and sensitive detection of mucormycosis. The assay incorporates specifically designed primers capable of detecting as low as 0.001 picograms (pg) of spiked genomic DNA from Mucorales fungi. This LAMP assay demonstrated a high sensitivity of 98% and a 100% specificity of detecting fungal ribosomal DNA (rDNA) in bronchoalveolar lavage (BAL) samples collected from mice infected with Mucorales fungi (n = 48) or from an uninfected control group (n = 15). To align the assay with clinical antifungal therapy, a subset of infected mice was treated with either liposomal amphotericin B (LAMB) or a combination of LAMB and a humanized monoclonal antibody (VX-01) targeting the Mucorales-specific surface protein CotH3. Consistent with the treatment efficacy, the LAMP assay detected significantly lower fungal burdens in BAL samples from mice receiving the combination therapy compared to those treated with LAMB alone or placebo. Further validation was conducted using BAL samples from patients diagnosed with mucormycosis (n = 24) or aspergillosis (n = 17). The assay demonstrated a sensitivity of 79% and a specificity of 94%. These findings highlight the diagnostic potential of this LAMP-based assay as a point-of-care. Its high sensitivity, specificity, and rapid turnaround time position this assay as a promising tool for early and accurate detection of mucormycosis, with the potential to improve patient management and clinical outcomes.IMPORTANCEMucormycosis is a rapidly progressive and fatal fungal infection. Timely diagnosis is critical for effective treatment, yet current diagnostic tools are slow, insensitive, or require complex laboratory procedures. In this study, we developed and validated a colorimetric loop-mediated isothermal amplification (LAMP) assay that enables rapid and reliable detection of Mucorales DNA directly from bronchoalveolar lavage (BAL) specimens. The assay demonstrated high sensitivity and specificity in both experimental mouse models and clinical samples, producing results within 1 h without the need for sophisticated equipment. This simple, robust, and cost-effective molecular diagnostic tool holds great potential for early detection of mucormycosis, facilitating prompt antifungal therapy and improving patient survival.
New LAMP assay detects mucormycosis with 98% sensitivity (mice) 🐭, 79% (patients) 🧑⚕️ & 94-100% specificity 🎯 in ≤1h, aiding early treatment & better outcomes.⏱️💉
27.02.2026 05:30 —
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Whole genome analysis of azole-resistant Candida tropicalis candidemia outbreak in a haematology ward: a single centre experience https://pubmed.ncbi.nlm.nih.gov/41758109/
01.03.2026 11:21 —
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