Anthony Berndt

Last year it was discovered that a single bacterial NLR-like protein can recognize multiple, structurally unrelated phage proteins (Béchon et al, Kibby et al)

Now, a new study shows the same for a plant NLR. Another example how principles of immunity remain conserved from bacteria to eukaryotes

Alberta Strong and Free, Notwithstanding The UCP's Bill 2 skirts the legislature and the courts, leaving it up to the public to push back swiftly

The UCP government has invoked time allocation and on a bill removing Albertans' Charter rights.

And they're using the notwithstanding clause to do it.

Here's why that is a dangerous precedent. And why real conservatives need to stand up against it.

open.substack.com/pub/drjaredw...

Today in accidental data art: selecting the wrong chart type.

If someone wants to write a new article on this, and highlight how current genetics tools have opened the door for many more, I'd be happy to consider it for CSH Protocols.

Someone is going to get denied their ration of crayons

does anybody know a good history of medicine that covers the era when laboratory tests became more common? specifically i’m looking for something that would cover/go into detail about how reference ranges for “normal” lab results were determined.

Forever Canadian Official Campaign Website Forever Canadian campaign is a grassroots coalition of Canadians aimed at reinforcing Canadian unity. It is a proactive vehicle to secure Alberta's continued place in Canada.

🗣Stand with Canada🇨🇦!

🟢Sign📝 the #ForeverCanadian petition to keep Alberta strong✊️, united🫂, and free🕊 from foreign influence. 👍

✅️Together, we protect🛡 our democracy🕊, our #CharterOfRights📜 & our freedoms.❤️✊

#cdnpoli #cndpoli #CanadaStrong #abpoli #Alberta
www.forever-canadian.ca/sign-the-pet...

Beadwork showing different DNA patterns, including one that is displayed on a dog mannequin

Erica Lord, the Codes We Carry, beaded DNA #sciart for Indigenous Peoples Day
ericalord.com

Thanksgiving in Canada has nothing to do with Columbus!

We are a colonial country with a million things to atone for but Thanksgiving is not one of them.

Our Thanksgiving is timed with the harvest and it's literally just "Be grateful for harvest"

US Imperialism has brain rotted too many of you.

A diagram of the bones and (some) deep muscles of the hand and forearm. AI says that we only have four digits. It’s also identified a tendon as the median nerve, another tendon as the ulnar nerve, among other issues.

An AI generated diagram of the muscles of the neck. It hallucinated the “ennocleidomasid” muscle, and the “anterior scalpalin muscle”.

An AI generated diagram of the muscles of the lateral thigh. It says that the gluteus Maximus (the big juicy butt muscle) is on the anterior side. It also points to the quadriceps muscle and says “attattment”. It also says that the same structure is the tibia AND the deep fascia of the leg.

An AI generated diagram of the bones of the hand and forearm. This time AI says we have 6 digits. It also says that the radius is the ulnar artery. Among other many issues.

A student on TikTok has been documenting her journey with a professor who “wrote” the anatomy textbook and it’s all a bunch of AI hallucinations.

She’s saying that, understandably, the students are doing super poorly!

Behold what we’re teaching the healthcare professionals of tomorrow:

Disease prevalence in US states before & after vaccine introduction 🧪

From Edward Tufte & graphics.wsj.com/infectious-d...

In all seriousness, the "LLMs are people and you're racist if you don't like them" shit is the natural endpoint of a consumerist society in which consuming and fandom are the only modes of identity-building many people understand. Finally, a product no one can tell you not to love.

This is why we fund scientists to study things like oyster slobber even if you don’t think it sounds important

Of course, of COURSE, Danielle Smith blamed Ottawa for Imperial Oil's plan to lay off 20 per cent of its employees by 2027.

continued: Canada Post ships letters. LETTERS. Skinny. Mid-size. Chonky. Thicc. Tiny little postcards. Big fat letters. Book-sized letters. Divorce-paper chonk-size letters. Skinny driver's license letters. Chunky catalogue letters. Thicc magazine letters. Imagine a world where Canadian companies have to pay over $15 to a US parcel delivery service (FedEx and UPS) to mail a university acceptance letter from Toronto to Red Deer. Is this what you want?

2/

It's just I've seen ppl bemoan "the state state of science" here and there, and what they actually mean is "I only read the 'science' headlines on CNN."

Like, no. Amazing things are happening. And I mean straight sci-fi shit. "We could conclusively prove extraterrestrial life exists in 2040" shit.

After 10 years of work, a complete telomere-to-telomere gap-free genome for C. elegans finally exists: it has 106 Mb rather than the textbook 100.3 Mb, and up to 366 additional genes.
genome.cshlp.org/content/35/8...

Super excited that this story by @borissieber.bsky.social is now on BioRxiv!

For decades, we thought there was no MAPK scaffold for the ERK-like cascade that promotes sexual reproduction in fission yeast ... until Boris found it !

See the thread 👇 and enjoy the paper!

doi.org/10.1101/2025...

Every year my mom gets us each a bird ornament, she texted us all today asking which we each want

My siblings never indulge in text conversations, but we’ve been chatting in that text chain for over an hour now.

Thoughts and prayers for my mother, who’ll wake up to 105 increasingly unhinged texts

Yes. But seeing how many professors were silent or neutered when it came of field-known assholes/bullies/abusers/sex-pests/rapists, I'm expecting absolutely nothing.

FWIW, it's telling me that at least half of the federal conservative voters aren't absolute traitors.

At the same time, I'm not sure where a Red Tory would go but being a Liberal voter these days.

a glass mug of a & w beer with foam on top Alt: a glass mug of a & w beer with foam on top. The foam spills over slowly.

Let's talk about root beer & why you've probably never tasted real sassafras OR sarsaparilla.

Root beer was originally made by adding yeast to a syrup made from the pulverized root bark of a sassafras tree.

Sassafras produces SAFROLE, a compound that deters animals from eating the bark or leaves.

I’m not the first person to make this observation, but this being the biggest story in the world at present really speaks to how much Twitter still serves as a universal assignments editor for English-language journalists.

With iNaturalist, GBIF, and an increasing amount of scientific literature online, it is now possible to identify many bugs from all over the world without having to get physical specimens in front of an expert. Last 5 years especially.

Sedation dentistry is no longer weird. Phone cameras are really good. The price of solar panels has dropped by tens of thousands. Southern white rhinos, giant pandas, Arabian oryx and Stellar sea lions are no longer endangered.

And, I can testify, modern cancer treatments are fucking amazing.

A call for caution in the biological interpretation of viral auxiliary metabolic genes - Nature Microbiology This Perspective discusses virus-encoded auxiliary metabolic genes and provides a framework for the biological interpretation of these genes.

#Perspective

A discussion on virus-encoded auxiliary metabolic genes and a framework for the biological interpretation of these genes.

#MicroSky 🦠

www.nature.com/articles/s41...

Much like "crab", industrial music is constantly re-evolving from first principles basically anywhere where there's a bunch of metal and plastic laying about

Thank you. To be clear, I did not merely “dismiss” AI as mid. My argument is that LLMs 1) are not intelligent 2) average textual responses in a way that is mid 3) most generous use cases are a revolution of middle skills that don’t produce anything ergo LLMs are in every demonstrable way mid.

I love our town fair day, but there's always one violent idiot who has to ruin it for everyone, trundling around making threats.

Collective cell motion has many forms, but rotation is the coolest of them all.

I'm @onenimesa.bsky.social , and in this short🧵, I'll highlight some instances of global tissue rotation like this one from @BauschLab