Nicolas Bidere

Activation of lysosomal iron triggers ferroptosis in cancer - Nature Some cancer cells exhibit high loads of reactive iron in lysosomes, and this feature is exploited by using fentomycin-1, a newly developed small molecule, to induce ferroptosis.

This week #JournalClub #ferroptosis #iron #lysosome @nature.com @institutcurie.bsky.social www.nature.com/articles/s41...

👏 Congratulations #YanisMace @nbidere.bsky.social @tiphainedouanne.bsky.social @insermgrandouest.bsky.social
🔍 CYLD cell death and more

Important Fact: Higher Education and Research is the place where LGBTI+phobic assaults are most common.

What can we do?
- Continue to stay informed and educated
- Include and make LGBTI+ people visible
- Reject harmful behaviors

Here is our SOAPainbow 🌈

Un article intéressant sur les #PFAS rédigé par un petit groupe de lycéennes #nantes dans le cadre de programme Jeunes Reporters pour l’Environnement, porté par Teragir. Bravo !

Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins Breakdown of every transmembrane protein trafficked to lysosomes requires proteolysis of their hydrophobic helical transmembrane domains. Combining lysosomal proteomics with functional genomic dataset...

This #JournalClub @labsoap.bsky.social #Lysosomes #CellDeath #Degradation @science.org @robzonculab.bsky.social www.science.org/doi/10.1126/....

Blebbisomes are large, organelle-rich extracellular vesicles with cell-like properties - Nature Cell Biology Jeppesen, Sanchez et al. identify blebbisomes as large membrane-enclosed vesicles containing organelles and secreted by cells. Blebbisomes can both secrete and internalize exosomes and microvesicles.

This week @labsoap.bsky.social #JournalClub #bleb #extracellularvesicle @naturecellbiology.bsky.social www.nature.com/articles/s41...

Cancer du cerveau : « On avance », dit la chercheuse nantaise À l’occasion de la semaine du cerveau, focus sur Julie Gavard, qui encadre une équipe de chercheurs et de thésards qui planchent sur les tumeurs malignes du cerveau de l’adulte.

merci @ouest-france.fr pour la mise à lumière des travaux #recherche #cancer #cerveau #liguecontrelecancer @insermgrandouest.bsky.social @cnrsbiologie.bsky.social @sdcnantes.bsky.social
www.ouest-france.fr/sante/cancer...

Huge congratulations to the postdocs from @labsoap.bsky.social for this inspiring essay. Very happy to see it published.
A must Read!

FEBS Press ‘Who in their right mind would add another meeting to an already overflowing schedule?’ This thought crossed our minds when we first discussed the idea of a postdoc peer group meeting. We are five ea....

👀 📝 Words of Advice #co-development #postdocs @febspress.bsky.social @tiphainedouanne.bsky.social @laisbfugio.bsky.social #JaneJardine #QuentinRoux @sararosinska.bsky.social in @labsoap.bsky.social @nbidere.bsky.social @insermgrandouest.bsky.social
febs.onlinelibrary.wiley.com/doi/10.1111/...

Our #2025 SOAPbox @labsoap.bsky.social getting ready to celebrate our 10th year anniversary in #nantes 🎁🎂🎊

No #JournalClub this week instead Brain Awereness Week @semaineducerveau.bsky.social #Nantes

L’Inserm est très concerné par le sort de la science et des scientifiques aux Etats-Unis, ayant des relations étroites historiques avec de nombreuses institutions scientifiques américaines et en particulier le NIH et des programmes scientifiques communs. Plus largement l’Inserm est solidaire du mouvement Stand Up For Science et est solidaire de tous les scientifiques exerçant aux États-Unis, où la liberté académique est aujourd’hui mise à l’épreuve. L’Institut souhaite rappeler l’importance de la science et du progrès dans le monde actuel, où nous sommes confrontés à de nombreux enjeux de société et de nombreuses crises.

L’Inserm est solidaire du mouvement Stand Up For Science

presse.inserm.fr/cest-dans-la...

#StandUpForScience2025

This week #JournalClub @labsoap.bsky.social #glioblastoma #traf3 #lipid @jclinical-invest.bsky.social www.jci.org/articles/vie...

À l’occasion de la Journée internationale des femmes et filles de science, testez vos connaissances sur les femmes scientifiques et l’égalité dans la recherche.
👉 mpdf.cnrs.fr/le-quiz-femm...

#FemmesEnScience #WomenInScience

Microplastics in the bloodstream can induce cerebral thrombosis by causing cell obstruction and lead to neurobehavioral abnormalities Microplastics get in the blood and are eaten by immune cells, leading to cell obstruction and cerebral thrombosis.

This week #JournalClub @labsoap.bsky.social on #microplastic #bloodbrainbarrier #plastifou in @science.org
www.science.org/doi/10.1126/... 🧠🏭🍃

Thanks to #OTablo initiative #NantesUniversité we could draw @labsoap.bsky.social team recent work on #centriolarsatellites 🖼️🎨🖌️🧑‍🔬🔬 and its beautiful !
Kudos to all involved 🤗

Monitoring concentration and lipid signature of plasma extracellular vesicles from HR+ metastatic breast cancer patients under CDK4/6 inhibitors treatment Extracellular vesicles (EVs) are cell-derived small membrane structures that transport various molecules. They have emerged as potential circulating biomarkers for monitoring responses to cancer ther...

please check our recent publication on #EV #extracellularvesicle #breastcancer #lipids @insermgrandouest.bsky.social #JExtracellBio isevjournals.onlinelibrary.wiley.com/doi/10.1002/...
thanks to all involved including our funding agencies

#SOAPosium was a fantastic moment of science food and fun 👩‍🔬🔬🍭🍪😹😆 - 🙏🏻🙏🏻🙏🏻🙏🏻🙏🏻🙏🏻🙏🏻

and what about our #BigPicture #SmallPicture #SOAPosium #Cover 😍

@labsoap.bsky.social is proud to announce the 8th SOAPosium on the 12th of December, one more year of SOAP to enjoy together with our guest #VincentSauzeau #InstitutduThorax @insermgrandouest.bsky.social
All we want is teamwork (and chocolate) 🎵

The RBR E3 ubiquitin ligase HOIL-1 can ubiquitinate diverse non-proteinaceous substrates in vitro https://www.biorxiv.org/content/10.1101/2024.11.29.626046v1 HOIL-1 is a RING-between-RING (RBR)-family E3 ubiquitin ligase and component of the linear ubiquitin

The RBR E3 ubiquitin ligase HOIL-1 can ubiquitinate diverse non-proteinaceous substrates in vitro https://www.biorxiv.org/content/10.1101/2024.11.29.626046v1

Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers Diepstraten et al. demonstrate that p53 enforces apoptosis induced by BH3-mimetic drugs. To boost BH3-mimetic-induced apoptosis in TP53-mutant blood cancers, STING agonists were employed to induce pro...

This week #JournalClub @labsoap.bsky.social #Cancer_Cell
#P53 #STING #BH3mimetics www.cell.com/cancer-cell/...

#happyteam #SOAPteam