The Science of CAR-T Cell Therapy: Part 1 CAR-T Structure, Function, Applications and Safety

Check out my literature review article on cell therapy! medium.com/@dougjo87/th...

✨Resplendent Quetzal✨

So lucky to see one of these magical birds the other day.

But did you know that their feathers aren't actually green? They actually look green because of how they bend light. There’s no green pigment at all, and they can even look brown under different lighting.

🪶🧪🌍

I’m planning a community science fair. You should, too.

Check out my latest post on medium: medium.com/@dougjo87/im...

Famous double-slit experiment holds up when stripped to its quantum essentials.

#science #physics #news

www.lifescience.net/news/6475/fa...

Thanks for the repost!

Where do you see automated cell processing technology in 5 years?

Thrilled to be accepted to this event in DC in September. Looking forward to connecting with the #NSPN and everyone that will be in attendance!

Douglas Job – Medium Read writing from Douglas Job on Medium. Writing on science, policy, and innovation, with the occasional updates on The Flemington Science Collective as well as leadership.

Follow me at medium.com/@dougjo87!

Why is CD19 such a successful target in treating B-cell malignancies? CD19, through its interaction with other proteins in the cytoplasm of the B cell, sets off multiple signaling pathways that contribute to B…

I created a Medium account to kick-start my writing life. First short article posted yesterday, second on target for tomorrow. Read my 2 min article about CD19 here: medium.com/@dougjo87/wh...

Screenshot with a blue background. There is a white box that looks like the top of a protest sign, with blue writing that says “Defend public health”. The words are stacked on each other. In between the N in defend and the I public there is a tiny orange flame. Below that it says science compassion people power.

We wanted to share something about our logo.

It is meant to evoke a protest sign. And there is a candle flame in the negative space.

We and so many others are working to keep that flame lit.

We are grateful to the very talented volunteer who designed it but wishes to remain anonymous.

I'll be sharing my progress on organizing a #sciencefair in the upcoming days! More details to come. #newjersey #LSEN #aaas #hunterdoncounty #centraljersey #community

A Nanovial-Based Platform for Functional Discovery of Antigen-Reactive TCRs from Unconventional T Cells Unconventional T cells, such as mucosal-associated invariant T (MAIT) cells and invariant natural killer T (iNKT) cells, recognize non-peptide antigens presented by MR1 and CD1d, respectively, and pla...

www.biorxiv.org/content/10.1...

Leadership in Turbulent Times is one of the best books on leadership I've read. Examining pivotal moments in 4 presidencies, this book intertwines laudable leadership achievements, challenges, and relatable moments within the context of US history. I highly recommend it.

Jennifer Doudna is named 2026 Priestley Medalist The award recognizes the biochemist for discoveries on ribozyme function and CRISPR gene editing, and international science leadership

Jennifer A. Doudna will receive the 2026 Priestley Medal, the highest honor given out by the American Chemical Society. She helped discover the gene editing technology CRISPR and has made many contributions to our knowledge of RNA chemistry. cen.acs.org/people/award...

Promotional graphic for "Somebody Should Do Something: How Anyone Can Create Social Change" on a blue-green gradient background. A 3D image of the book is on the right. To the top left is an endorsement from Kate Marvel, author of Human Nature, that reads "In Somebody Should Do Something, Michael Brownstein, Alex Madva, and Daniel Kelly neatly dispense with the false divide between individual action and systemic change. . . . Most importantly, the book provides concrete suggestions for organizing, coalition-building, and finding your own place in creating change."

Combining compelling stories with science, "Somebody Should Do Something" explores how personal choices, when linked with collective action, can drive the big structural change needed to tackle systemic issues.

Out Sept. 16th: mitpress.mit.edu/978026204978...

Also wanted to add that your work and that of your team is an inspiration to all of us in cell therapy.

Very exciting for allogeneic development! Looking forward to the published article, I'd like to see the duration/"degree" of TCR silencing in vivo if it was analyzed. This is a great proof of concept that it can be done. I'd love to see a TCR knockout/silenced PD-1 in vivo. Thanks for sharing!

De novo design and structure of a peptide–centric TCR mimic binding module T cell receptor (TCR) mimics offer a promising platform for tumor-specific targeting of peptide–major histocompatibility complex (pMHC) in cancer immunotherapy. In this study, we designed a de novo α-...

Researchers leveraged AI tools RFdiffusion and ProteinMPNN to develop a de novo protein/mini-TCR mimic targeting NY-ESO-1 (cancer testis antigen). Exciting times for drug discovery.

De novo design and structure of a peptide–centric TCR mimic binding module | Science www.science.org/doi/10.1126/...

I hope a recording is available!

Tune in now to #CGCAnnual2025 to hear Keynote Speaker Will Parsons from Baylor College of Medicine & Texas Children’s Hospital as he presents “Clinical application of genomics for childhood cancer patients—an update on two decades of precision oncology.” In this session we’ll: 1/5