Gladstone Institutes

A memorable moment from earlier this year—San Francisco Mayor Daniel Lurie's visit to Gladstone! #YearinReview

Take a look at more highlights from his visit: https://bit.ly/4oAYt1C

AI Accelerates ALS Research | ALS Network Dr. Steve Finkbeiner and his team at the Gladstone Institutes have developed an AI-powered “thinking microscope” that can independently run experiments, learn from what it observes, and rapidly analyze data — far beyond human capacity. By applying AI approaches similar to large language models...

Our scientists are pushing boundaries with AI approaches similar to large language models. By teaching machines to understand biological patterns, we're accelerating the discovery of new treatments for devastating diseases. The future of medicine is happening right here at Gladstone!

What a day at the 2025 Ogawa–Yamanaka Stem Cell Prize Ceremony! We honored Rudolf Jaenisch for his groundbreaking contributions to stem cell biology and epigenetics.

Thank you to everyone who joined us and helped make the celebration special!

Today is J. David Gladstone's birthday—the man behind our name.

His generosity paved the way for our journey. Discover more about his inspiring story: https://bit.ly/2ENrx5M

Six Gladstone Scientists Named Among World's Most Highly Cited Researchers The featured scientists include global leaders in gene editing, data science, and immunology.

Congratulations to our six Gladstone scientists recognized as 2025 Highly Cited Researchers by Clarivate!

Their groundbreaking work places them among the world’s most influential researchers, highlighting a decade of excellence and impact in their fields. 🌟👏

CRISPR Behaves Differently in the Brain Than Anywhere Else A new study shows that neurons repair CRISPR-Cas9 cuts in unique, highly predictable ways, unlike dividing cells. Researchers found Cas9 persists far longer in neurons and triggers unexpected repair p...

Researchers discovered why #CRISPR behaves differently in neurons, revealing repair patterns.
https://bit.ly/4imbtqv

YouTube video by Gladstone Institutes How Scientists Are Using Gene Therapy to Regenerate Heart Tissue

Deepak Srivastava explains groundbreaking research in cardiac regenerative medicine. Scientists have discovered how to reprogram adult cells using specific master genes, potentially offering new treatments for heart failure.
https://www.youtube.com/watch?v=3mnHLTqwKHA

Jon Muncie-Vasic explains why it’s still crucial to get to the root of congenital heart defects and how understanding early heart development is key to preventing congenital heart defects and reducing their lifelong impact.

The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2 The development of new small molecules demonstrates how pharmacologic inhibition of the coronavirus macrodomain restores innate immunity, leading to reduced viral replication and improved outcomes in ...

🚨 🚨 NEW PUBLICATION 🚨 🚨 "The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2" from @theottlab.bsky.social in @elife.bsky.social

The genome editing playbook is different in neurons and other nondividing cells, researchers discover The gene editing tool known as CRISPR-Cas9 is changing what's possible for treating a wide range of diseases caused by genetic mutations. But so far, attempts to use the technology to address brain-based genetic disorders have proved challenging in the ...

A new study from Gladstone could influence how gene therapies are designed for many genetic diseases.

Introducing 2025 Glenn Foundation for Medical Research Postdoctoral Fellowships in Aging Research recipient Nalini Rao, PhD, of the @gladstoneinst.bsky.social, who will research “Elucidating how aging impairs brain proteostasis and protein clearance.”
Learn more here: www.afar.org/grantee-prof...

This month, we're revisiting some of our top stories from 2025.

In this Q&A from January, Virologist Melanie Ott shared scientific insights into the virus that prompted California Gov. Gavin Newsom to declare a state of emergency.

Read more: https://bit.ly/4jm7aLO

HIV Cure Lab Tour + Q&A | LIVE Event 2 people registered for this event. See what's going on there!

Tomorrow! Join this TikTok live and get an inside look at an HIV cure research lab. Meet meet the scientists bringing us closer to ending HIV.

@theottlab.bsky.social

Tomorrow! We're honoring Rudolf Jaenisch with the 2025 Ogawa-Yamanaka Stem Cell Prize.

Join us as we celebrate his groundbreaking work in epigenetics and stem cell biology. Don't miss his scientific lecture! 🧬🔬

Register: https://bit.ly/4gNhf3z

News: Neurons repair CRISPR damage with unique timing - CRISPR Medicine Neurons show slow and distinct DNA repair responses after CRISPR editing, challenging assumptions based on dividing cells. Researchers demonstrate that manipulating these repair pathways in nondividing cells can direct outcomes and improve editing effic...

Bruce Conklin and his team demonstrate that manipulating DNA repair pathways in nondividing cells can direct outcomes and improve efficiency of #CRISPR genome editing.

Scientists at Gladstone and @ucsanfrancisco.bsky.social have discovered a new way to outsmart COVID-19. Their study reveals that the molecule AVI-4206 blocks a key viral protein called Mac1—stopping the virus from hiding from our immune system.

@theottlab.bsky.social



https://bit.ly/3Xi6ldm

🧡🍁 Happy Thanksgiving from Gladstone! 🧡🍁

We’re grateful for the scientists, trainees, staff, collaborators, and supporters who drive discovery every day.

Regulating this gene is essential to immune system balance Researchers have mapped the regulatory elements that control the FOXP3 gene, which is implicated in maintaining balance in the immune system.

Scientists from Alex Marson’s lab have mapped the regulatory elements that control the FOXP3 gene, which is implicated in maintaining balance in the immune system.

Scientists learn to fine-tune a gene that is centrally involved in regulating the immune system, offering potential clues for future autoimmunity and cancer treatments.

Read more about this new study on our website: https://bit.ly/4nUtpcT

HIV Cure Lab Tour + Q&A | LIVE Event 2 people registered for this event. See what's going on there!

In honor of World AIDS Day, take an inside look at an HIV cure research lab to meet the scientists bringing us closer to ending HIV.

Join the live tour on TikTok on December 1.

Researchers Reveal Intricate Control System for Key Immune Gene Scientists learn to fine-tune a gene that is centrally involved in regulating the immune system, offering potential clues for future autoimmunity and cancer treatments.

What does the fox say? 🦊 Dr. Alex Marson (@marsonlab.bsky.social) and scientists have the answer! Using CRISPR-based gene silencing technology, they mapped the network of genetic switches that immune cells use to fine-tune FOXP3 levels.

@gladstoneinst.bsky.social @ucsanfrancisco.bsky.social

CRISPR Behaves Differently in the Brain Than Anywhere Else A new study shows that neurons repair CRISPR-Cas9 cuts in unique, highly predictable ways, unlike dividing cells. Researchers found Cas9 persists far longer in neurons and triggers unexpected repair p...

Researchers discovered why #CRISPR behaves differently in neurons, revealing repair patterns.

Exciting news! We're honoring Rudolf Jaenisch with the 2025 Ogawa-Yamanaka Stem Cell Prize on December 1.

Join us as we celebrate his groundbreaking work in epigenetics and stem cell biology. Don't miss his scientific lecture! 🧬🔬

Register: https://bit.ly/4gNhf3z

Cell Signals〡The Genome Editing Playbook Is Different in Neurons In today’s newsletter, a new study could impact how gene therapies are designed, scientists explain how they identified a gene driving heart defects in Down syndrome, and find out how to register for ...

In our November newsletter, a new study could impact how gene therapies are designed, scientists explain how they identified a gene driving heart defects in Down syndrome, and find out how to register for the 2025 Ogawa-Yamanaka Stem Cell Prize Award Ceremony.

https://bit.ly/44jCdC7

Scientists learn to fine-tune a gene that is centrally involved in regulating the immune system, offering potential clues for future autoimmunity and cancer treatments.

https://bit.ly/4oc6dXU

From her home on Potrero Hill to her lab just a few blocks away, Katie Pollard is using AI to teach computers how to read DNA — with the goal of predicting disease risk long before symptoms show up.

CHCHD2 mutant mice link mitochondrial deficits to PD pathophysiology A CHCHD2 mouse model of Parkinson’s disease exhibits mitochondrial disruption with a metabolic shift toward glycolysis.

🚨 🚨 NEW STUDY 🚨 🚨 "CHCHD2 mutant mice link mitochondrial deficits to PD pathophysiology"

New from IGI's @bruceconklin.bsky.social!

Lennart Mucke reflects on how Alzheimer’s research has evolved since the founding of the Gladstone Institute of Neurological Disease.

#AlzheimersAwarenessMonth

Late-Onset Parkinson's Linked to Mitochondrial Protein CHCHD2 The mitochondrial protein CHCHD2 can drive a sequence of cellular events that lead to the development Parkinson’s disease (PD).

New research from the Gladstone reveals that the mitochondrial protein CHCHD2 may play a key role in triggering Parkinson’s disease, highlighting a new direction in understanding how the disease begins.