Mike Bottery

Very productive and balanced discussion on how best to tackle environmental resistance within human fungal pathogens. Sustainable data driven solutions are generated by open dialogue and effective networks.

Presenting my perspective on the role of academic science on the issues of antifungal dual use at the Brazilian Network Meeting on Aspergillus fumigatus Antimicrobial Resistance. @f1amr-network.bsky.social @fbmh-uom.bsky.social

Research Technician: www.jobs.manchester.ac.uk/Job/JobDetai...
Postdoc: www.jobs.manchester.ac.uk/Job/JobDetai...

Exciting news! I have two positions open in my lab at the UoManchester: one PDRA and one Research Tech.
Join our team to study evolutionary mycology and help us understand antifungal resistance in fungal pathogens. A fantastic opportunity to join the brilliant Manchester Fungal Infection Group!

Graph: global incidence and mortality of sever fungal disease

Currently hosting event on antifungals in medicine and agriculture, focusing on #AntiMicrobialResistance #AMR. With 6.5 million invasive infections globally each year, and 3.8 million deaths attributable to them. Area of fast-rising concern!

Very proud of Ed's first conference talk at #BSMM2025 did great despite the technical hiccups!!

Thanks Ville!

Interested in working on Mucorales adaptation? Thanks to new funding from @wellcometrust.bsky.social, we will have two postdoc and a technician positions advertised very soon! if interested, please get in touch for more information.

Exciting opportunities to join me in this research will be coming soon! If you're passionate about understanding microbial evolution & tackling antimicrobial resistance, keep an eye out or feel free to get in touch. 🔬🧬 🍄 #AMR #Microbiology #Evolution

Thrilled to announce I've been awarded a @wellcometrust.bsky.social Career Development Award at @fbmh-uom.bsky.social , University of Manchester! My research will investigate the remarkable adaptability of Aspergillus fumigatus, a deadly fungal pathogen, to help combat drug resistance.

Dr Colin Brown, deputy director at the UK Health Security Agency, responsible for AMR, said: “Phage therapy truly has the potential to transform the way we treat bacterial infections, especially as resistance to antibiotics grows. At UKHSA, we’re developing new ways to help increase phage therapy use and research, including a bacteriophage collection where scientists can both access and deposit phages. In time, we hope solutions like phage therapy can become a first-line treatment option.”

The MHRA today released new guidance for #Phage therapy in the UK. This will provide direction for scientists and researchers working to make this treatment a reality for patients. 🔬 🧪

🔗 www.gov.uk/government/n...

Chromosomal resistance mutations facilitate acquisition of multidrug-resistance plasmids in Escherichia coli Bacteria can gain multiple resistance mechanisms in a single step by the acquisition of multidrug-resistance (MDR) plasmids, but it is unclear how antibiotic selection during the acquisition of MDR pl...

New preprint with nice detective work by PhD student Khadija Hanga: gain of pOXA MDR plasmid is facilitated by chromosomal mutations affecting OmpF which act synergistically with the plasmid’s carbapenamase to give high level resistance. Led by @mbottery.bsky.social www.biorxiv.org/content/10.1...

@wellcometrust.bsky.social Thanks for organizing the ERC meeting. I found the research culture activity really helpful, so many great thought-provoking ideas

Beautiful day to get out of the office and do some fieldwork! Soil samples + 🍄 #failsafe #mycology @normanvanrhijn.bsky.social

Thanks Amelia!

Sounds really exciting Bex!! I kinda miss symbionts, looking forward to hearing about you get up to

Through the pervasive anthropogenic use of agricultural azoles, a lineage of A. fumigatus has been selected that is multi-azole resistant, multi-fungicide resistant, and also displays increased adaptability, which ultimately will lead to the evolution of a lineage that manifests pan-drug resistance.

Here, we show that variants in the MMR gene, msh6, are almost uniquely found in strains harbouring azole resistance and result in up to 5-fold increase in mutation rates.

Resistance to azoles is spreading most likely due to the use of agricultural fungicides. Resistance can double the risk of mortality from invasive aspergillosis.

Only three classes of antifungal drugs available to treat disease, and only one class, the azoles, is suitable for long-term oral administration.

The mould, found in soil, composts, and decaying vegetation, is potentially deadly to people with a range of health conditions including those with weakened immune systems and respiratory problems.

Elevated mutation rates in multi-azole resistant Aspergillus fumigatus drive rapid evolution of antifungal resistance Nature Communications - Here, Bottery et al show that resistance to next generation antifungals is more likely to occur within azole resistant Aspergillus fumigatus due to the close linkage between...

New in Nature Comms, we show that azole-resistant Aspergillus fumigatus are more likely to evolve resistance to new antifungals due to variants in their DNA mismatch repair system rdcu.be/d3Iyc @natureportfolio.bsky.social #microsky #fungi #amr

Ecological and evolutionary mechanisms driving within-patient emergence of antimicrobial resistance - Nature Reviews Microbiology In this Review, Shepherd, Brockhurst and colleagues explore the clinical evidence in support of four major ecological and evolutionary mechanisms of within-patient antimicrobial resistance emergence i...

In case you missed it: @matthewjshepherd.bsky.social surveyed the clinical literature to reveal how #AMR evolves within patients, why eco/evo mechanisms vary among infections, & what we can do better to improve treatments www.nature.com/articles/s41... #MicroSky

It was great fun to be part of this project! Super cool to see Rock-Paper-Scissors dynamics in real microbial populations

PhD studentship alert!

Fully funded, co-supervised with @rokkrasovec.bsky.social and Prof Mike Bromley, University of Manchester

Exploring routes of horizontal gene transfer in pathogenic fungi

Exciting project, will be a bunch of fun! Come & join us 🔬

www.findaphd.com/phds/project...

Soil microbiomes show consistent and predictable responses to extreme events - Nature Soils from 30 grasslands across Europe were subjected to 4 contrasting extreme climatic events under drought, flood, freezing and heat conditions, with the results suggesting that soil microbiomes fro...

Soil microbiomes show consistent and predictable responses to extreme events
We’re out in Nature !! doi.org/ntzk Very exciting for my first bluesky post! – it’s been a long haul by an excellent team from across Europe, led by @frantecol.bsky.social

Fungal Genetics Stock Centre, there's something fishy going on here...

It was a pleasure to have the opportunity to present our work!

Sorry I don't think it's being recorded!

4pm at the Centre for Bacterial Cell Biology building