Yoav Gilad

Finally, today's offering! www.biorxiv.org/content/10.6...

This began life as a very different project which failed because we couldn't agree on defining eqtl sharing across cohorts. So two young members of the lab dug deeply into this - first @ijbeasley.bsky.social, then @patrickgibbs.bsky.social

CX-5461 and doxorubicin activate a shared DNA damage-associated transcriptional response in human cardiomyocytes Abstract. CX-5461 (CX) is under investigation for the treatment of late-stage cancers. While CX was first described as an RNA polymerase I inhibitor, it ha

Pre-print on cardiomyocyte response to novel anti-cancer drug CX-5461 now published! Includes new gene expression response data at higher CX doses. Response to micromolar CX doses starts to mimic DOX responses, suggesting that off-target effects on the heart should be considered for this drug.

I guess it's just hard to focus. I get that.

Anything really, but what I miss most are the paper/preprint announcements and related discussions.

I can hardly find science posts here. I don't know how to change that. Yes, I know a lot is going on (obviously), but I get all the other things everywhere... this was where I used to get the science 😞

Recommended

About | Who We Are — Under the Iceberg Learn about Under the Iceberg, a youth organization dedicated to nurturing future leaders through education and growth. Contact us to join or collaborate.

My daughter Maya, who had to wear a scoliosis brace for 2 years, wants to connect with other teens who live with invisible diseases. www.under-the-iceberg.com/about

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What a joke

Atari?

Biology Faculty Opportunities (Open Rank) - Galveston, Texas job with University of Texas Medical Branch | 676677 The Department of Biochemistry and Molecular Biology at UTMB Health invites applications for multiple tenure-track positions at all ranks; assistant,

We're hiring for multiple open rank positions in the broad areas of biochemistry, molecular biology, and computational biology. With the recruitment of a new chair our Departmental strengths now include nuclear architecture, genomics and ancient DNA.
jobs.sciencecareers.org/job/676677/b...

Faculty position at the department of medicine, University of Chicago. Please share.

I’ve been wondering more and more if TADs are about limiting recombination search and less about gene expression?

My lab is recruiting postdocs in AI/ML for genetics & genomics through the Malone Postdoctoral Fellows program. Apply by Jan 30! Lots of other great labs across the Malone Center as well.

academicjobs.uchicago.edu/positions/16...

An Intuitive Primer on Effective Functional Genomics Study Design|Paperback An Intuitive Primer on Effective Functional Genomic Study Design by Yoav Gilad addresses the unique challenges of designing experiments in the rapidly evolving field of functional genomics. Unlike tra...

The 400th copy of my book was sold yesterday. Thank you to everyone who ordered a copy! Some of you shared with me comments and suggestions, and I invite more readers to do so.

www.barnesandnoble.com/w/an-intuiti...

Thank you! send me an email and I'll reply with the images.

I didn't. I remember this post because it made me think. I've lost count of how many times I referenced it in conversations.

So what was the point of all this...? Why am I utterly not surprised

My book, An Intuitive Primer on Effective Functional Genomics Study Design, is published! I’d really appreciate it if you could help spread the word, and I’d love to hear your thoughts and feedback. I hope people will find it useful.

It’s available on Amazon: tinyurl.com/mx2hewen

As you can see I've been quite busy... 😀

Screenshot of text reading: "The original review had noted that "Mechanistic basis of how cells differentiate between [XXX and YYY] will be needed." However, rather than identifying a mechanism, the authors argue that "the mechanisms of both [XXX and YYY] are of great interest, and of little consequence to the claims—causal and otherwise—that we make". The mechanistic basis of cellular phenomena is the ethos of [ZZZ] as a journal as far as I understand, and it is disappointing that the authors regard the mechanisms to be inconsequential."

And to make this more concrete, here is a re-review we just got. The editor overruled this negative reviewer, who here is *lecturing us on the ethos of the journal*.

I've never met anyone in real life who holds this position with whom I can have an actual discussion. Always anonymous peer review.

Sean, this will pass. Harvard will receive federal funds again. I believe that you seriously doubt that right now. I don't. My outlook does not diminish the current crisis whatsoever, of course.

If you believe that, indeed the decision makes sense. In fact, it would be just the first step in a process of shutting down research altogether.

You can explain to me the complexity and rules related to endowment all you want, but there is just no way Harvard can't afford to keep their graduate programs intact. It's a choice.

Happy to be at ASHG!
2 students in the lab will present posters on gene regulatory evolution in primates on Thurs:
Emma focuses on responses to stimuli: 9109T
John focuses on transposable elements: 6036T
Please stop by if interested #ASHG25

Thank you for taking the time to review my book!

Interferon-sensitized hematopoietic progenitors dynamically alter organismal immunity Abstract. Inflammation has enduring impacts on organismal immunity. However, the precise mechanisms by which tissue-restricted inflammation conditions syst

Your immune system remembers skin inflammation long after it resolves because of #interferon alpha!
Check out our new paper describing these findings just published at
@jimmunol.bsky.social 👇👇👇

It was amazing working on this with my role model @drshrutinaik.bsky.social

but do you still need an R01 from NIGMS to be eligible for a new MIRA, or was that requirement dropped?

Graph showing total R35+R01 awards issued by NIGMS from 2020 to 2025. R01 in black showing a steep decline. R35 showing an increase. Total awards in 2025 slightly up from 2024 but these years are lower than 2020-2023

I think the R01 is basically a non-starter at NIGMS now. Data from NIH Reporter for new and competing awards, comparing number of R01s issued relative to R35s (MIRA). This has major ramifications for basic science and basic science investigators that are not yet in the MIRA pool