Cozy

Detection of cognitive deficits years prior to clinical diagnosis across neurological conditions Tai et al. describe distinct pre-diagnosis and post-diagnosis cognitive profiles of several neurological conditions with novel insights such as group-level

Detection of cognitive deficits years prior to clinical diagnosis across neurological conditions🔓
academic.oup.com/braincomms/a...

ME/CFS affects ~half of people w/Long Covid, and has overlapping symptoms w/many more. If your GP doesn’t know where to start, the US ME/CFS Clinician Coalition’s recs are a great place.

Testing: mecfscliniciancoalition.org/wp-content/u...

Treatment: mecfscliniciancoalition.org/wp-content/u...

a blue background with the word public service written in white ALT: a blue background with the word public service written in white

Long COVID is REAL. I went from healthy to bedbound.
+65M+ worldwide are suffering. +Symptoms: fatigue, brain fog, dizziness, heart palpitations, hair loss, & more.

If you know someone with ‘mysterious symptoms’, it’s likely Long COVID, not perimenopause. Don’t ignore it. #LongCovidAwarenessDay

Microglia dysfunction, neurovascular inflammation and focal neuropathologies are linked to IL-1- and IL-6-related systemic inflammation in COVID-19 - Nature Neuroscience The authors show that brain inflammation in COVID-19 correlates with viral load, systemic inflammation and virus-sensing pattern recognition receptors. Microglial dysfunction occurs at sites of vascular inflammation with myelin injury and synapse loss.

A study in Nature Neuroscience shows that brain inflammation in COVID-19 correlates with viral load, systemic inflammation and virus-sensing pattern recognition receptors. Microglial dysfunction occurs at sites of vascular inflammation with myelin injury and synapse loss. 🧪

Today is International #LongCOVIDAwarenessDay.
How can you take action? 📢
- Talking about COVID and #LongCovid in the present tense.
- Wearing a respirator mask to protect yourself and others. 😷 buymask.ca
- Donating so that we can continue sending free masks to people in 🇨🇦 who need them.

Here's a major source of microplastics in soils.
Other sources, astonishingly, include the *deliberate application* of microplastics, to make soils more friable, and the plastic pellets in which many fertilisers are encased.
It is simply crazy and must stop now.
www.theguardian.com/commentisfre...

The image shows a woman with a distressed expression, holding her forehead with one hand and placing the other hand on her chest, possibly due to discomfort or dizziness. She is seated on a couch in a well-lit room, with a kitchen area in the background. Text on the left side reads "Pacing Upright Activity." The image includes a small arrow pointing to the right, and the bottom right corner displays a "10th Anniversary" logo.

The image provides an explanation of orthostatic intolerance (OI). On the left side, the text outlines that many people with long COVID, ME/CFS, and dysautonomia experience decreased blood flow to the brain when upright, leading to OI symptoms. It suggests taking breaks from upright activity to manage this. On the right side, a graphic shows a human figure with arrows indicating gravity's effect on blood flow when transitioning from lying down to sitting or standing. The description explains that the body typically adjusts to ensure adequate blood flow, but when this adjustment fails, OI symptoms occur.

The image shows a diagram of a human figure with arrows pointing to various parts of the body, indicating symptoms of orthostatic intolerance (OI), such as lightheadedness, dizziness, fatigue, chest discomfort, breathlessness, weakness, GI symptoms, tingling, and more. On the right side, suggestions for managing OI symptoms are listed: Lie down, elevate legs above the level of your heart, wear compression clothing, use cold packs on the abdomen, neck, or legs, and increase intake of sodium, electrolytes, and water (if approved by a medical provider).

🚶‍♀️ Pacing Upright Activity 🚶‍♂️
Living with #MECFS and #LongCOVID requires making hard choices—including time spent upright.

🔹 Break tasks into chunks
🔹 Use seated/recumbent options
🔹 Mobility aids help
🔹 Listen to your body

📥 Learn more: loom.ly/0Or2G20

@OpenMedF

Plasma proteomic evidence for increased β-amyloid pathology after SARS-CoV-2 infection - Nature Medicine Blood biomarkers in a middle-aged population suggest that SARS-CoV-2 infection is associated with greater brain β-amyloid plaque accumulation.

Plasma proteomic evidence for increased β-amyloid pathology after SARS-CoV-2 infection

www.nature.com/articles/s41...

Microglia dysfunction, neurovascular inflammation and focal neuropathologies are linked to IL-1- and IL-6-related systemic inflammation in COVID-19 - Nature Neuroscience The authors show that brain inflammation in COVID-19 correlates with viral load, systemic inflammation and virus-sensing pattern recognition receptors. Microglial dysfunction occurs at sites of vascul...

Microglia dysfunction, neurovascular inflammation and focal neuropathologies are linked to IL-1- and IL-6-related systemic inflammation in COVID-19

www.nature.com/articles/s41...

THIS is something I really wish able-bodied people understood. It's pretty much ME/CFS in a nutshell. I might be able to push through fatigue & other symptoms to do a task, but I'll almost certainly crash for days, weeks, or even permanently change my symptom baseline. There's always a cost.

"Stop killing people" pretty much sums up my politics these days, whether we're talking genocide, covid, the environmental/healthcare/housing crisis, food insecurity, police brutality, lack of disability rights, attacks on LGBTQ+ folx, no access to reproductive medical care, etc etc etc. Just stop.

He et al. introduced chimeric antigen receptor (CAR) T-cell therapy for #pediatric patients with refractory systemic lupus erythematosus, demonstrating promising #clinical outcomes and significant societal impact.
doi.org/10.59717/j.x...
#medicine #systemiclupuserythematosus #Research

A limited review found 23 patients had screws misplaced in their spines, 5 lost excessive blood; more than 40 had problems with consent; and in 35 cases there was poor surgical practice. 13 children at Manchester children’s hospital were also harmed...

Photo of my work ID badge with my name and photo. "Darren Parkinson, community nurse, CAMHS, Calderdale." Blue NHS lanyard is attached.

Yesterday #LongCovid cost me my job.

20 years working as a Learning Disability Nurse for the #NHS.

My livelihood gone, my role in life gone, my ability to help others gone.

Long Covid ruins lives.

Can't believe Biden admin did nothing for Long Covid, the whole 4 years.

ICYMI, 47 & fans launched "3rd Term for Trump" at CPAC & these signs were up there.
There’s even a resolution in the House to change the 22nd Amendment www.congress.gov/bill/119th-c...
Something specific to CONTACT your Reps about - it's HJRes29 Referred to House Judiciary Cmte
#PostcardsforAmerica

When is your driveway not private? Stuff investigation forces Google concession Analysis of Google Street View photos has opened a privacy Pandora’s box, leading to the tech giant’s speedy removal of some controversial images.

As Becky said, if I walked down your long driveway and took photos of your house and put them on the internet, you’d be livid. But that’s what Google Street View has been doing. While it says it’s an “error” the scale of it is significant.

Nina Dobrev

Did you ever see the movie Sick Girl?

What

Long COVID studies stymied by pharma’s lack of cooperation Academic researchers want to repurpose drugs for the condition. Manufacturers aren’t supplying them

Really upsetting stunning article where Avi Nath goes on the record with the names of people at Merck and Bristol Myers Squibb who denied him drugs to test his immune checkpoint inhibitor theory of Long Covid. Post-viral illness still has a serious image problem. cen.acs.org/pharmaceutic...

YouTube video by SciShow Exercise Actually Makes Chronic Fatigue Syndrome Worse

Wow—terrific work by @scishow.bsky.social explaining why exercise can be harmful in ME/CFS! Even gets into the scientific scandal that’s misled doctors for years on this point.

Wonderful thing to share w/anyone who’s newly ill, uninitiated family members, or even docs who might not be up to date!

I'm still awake, and it's 5am! Oh well.

Peach background. In black is copy that reads, "What is Unrefreshing Sleep?" Under that is white copy on a darker peach circular background that reads, "Dysregulated sleep: hard to fall asleep and/or stay asleep" Under that in blue copy over a green circular background it reads, "Wake up feeling tired or unwell" and the last "bullet point" is and white copy over the darker peach circular background, "Sleep that remains non-restorative". Next to the "bullet points" is a cartoon image of a person lying in bed. The view is from the ceiling looking down at them. There is a green pillow and blanket and the subject is in a blue pj top. There eyes are closed and their facial expressions shows frustration.

🌙 ME/CFS 101: What is Unrefreshing Sleep?
Sleep disturbances affect 90% of ME/CFS patients, with issues in sleep quality (light, restless, interrupted) & timing (delayed, irregular).
Dr. Bateman explains & offers tips: loom.ly/6Ss8msI
Stay tuned for more! 💬 #MECFS

Standing up for myself and calling out ableism because of my lived experience of being dismissed and ignored with a disease that runs counter to established narratives about health and exercise isn't about "poor me", it's about speaking for a community. Advocacy not playing the victim. -