Kate Stafford

Every so often I google something and the top hits are Reddit threads from 10-15 years ago - which doesn’t seem that long ago, but everything about the slang and typing style and general vibe feels like falling into a time warp.

Am I the only one who always feels like I have to praise the LLM whenever it does a good job? Who's a good boy? Is Claude a good boy?

This! And at the risk of going back to the messaging issue… resist the temptation to speak nonprofitese about it.

Yes: “Free eggs from the Democrats”

No: “Amplifying the voices of marginalized communities by expanding access to traditional foodways impacted by capitalist climate injustice”

I get wanting to reduce government inefficiency, but starting with foreign aid and biomedical research is crazy. The TSA is right there!

Have to admit I was expecting the “find out” phase of Trump 2.0 to start later than week 2.

GitHub - PatWalters/resources_2025: Machine Learning in Drug Discovery Resources 2024 Machine Learning in Drug Discovery Resources 2024. Contribute to PatWalters/resources_2025 development by creating an account on GitHub.

Machine Learning in Drug Discovery Resources page updated for 2025. github.com/PatWalters/r...

I spent a long time building a dataset, finally started training a model on it, and was so relieved to see the loss go down. Maybe the data sucks, maybe the model will suck, but at least I didn’t scramble the labels or make unusable data mud.

If the worst thing that happens in Trump admin 2.0 is that he's super corrupt and scams some crypto bros, we will be getting off easy. In fact we should encourage him to spend as much of his time as possible on crypto.

Classics in Medicinal Chemistry #1: Atorvastatin Lipitor

I have a new blog devoted to medicinal chemistry in which I will mainly focus on classic papers.

My first installment describes the design and discovery of the amazing atorvastatin: a triumph of simple modeling, dogged synthesis and leadership decisions medchemash.substack.com/p/classics-i...

Inconsistency of LLMs in Molecular Representations Large language models (LLMs) have shown promising potential across diverse chemistry tasks, including forward reaction prediction, retrosynthesis, and property prediction. However, their ability to ca...

I think that’s the wrong link? Looks like this one: doi.org/10.26434/che...

I accidentally put a cat toy in the washing machine and now the whole laundry pile smells like I used catnip-scented detergent.

Going to a musty basement and turning those big cranks to move the stacks in the library

Rewinding a cassette with a pencil

Blowing on a video game cartridge even though you kind of suspected it was just a placebo

It's like Zuckerberg is doing a Buscemi "Hello fellow Trumpers" gif.

*snort*

He’s getting divorced isn’t he

Fight! Fight! Fight!

I'll have to take Elon's side on this one, despite Bannon's doubtlessly sincere DEI concerns.

Check out our work, where we discover how receptor GPCR senses pH! We solved a longstanding question by developing foundational GPCR DMS tech dev + structural bio! Led by brilliant PhD student @matthewkhoward.bsky.social and Nick Hoppe w/ @amanglik.bsky.social!

www.cell.com/cell/fulltex...

Maybe the problems I give them are too easy, but whenever I ask an LLM to generate some code, the results are fine. No need for super elaborate custom prompts or a ton of back and forth.

lol I would not be surprised if someone in noe complained on nextdoor about this

I’m happy to see more outdoor markets in SF, but come on. If the hours are 3-7pm it is not a “night market”, even in Noe Valley.

Went to a yoga class slightly hungry. By the end I spent the entire shavasana thinking about the burrito I was going to get after class. Mmm, burrito meditation….

Here's a year-end update from #PLINDER. It's been really great working on this project and all the other projects that it has kickstarted - the gift that keeps on giving.

Happy holidays everyone!

www.plinder.sh/blog/updates

Good thing flight tracker sites exist so you can stress about how the plane assigned to your flight is late two legs before yours.

Just finding us here? Endpoints News has a starter pack with our journalists so you can follow the team!
go.bsky.app/NzDRUhL

Heh thanks, I think that’s the only one my intended recipient wouldn’t want!

Both cats are in my lap at the same time. That’s 24.5 pounds of cat. That is so much cat.

Do any of the big LLMs do gift subscriptions? Seems like OpenAI is a no. I hope at least one of these companies thought of this before Christmas.

Drinking and climbing without a safety harness? Definitely not OSHA approved

GitHub - bytedance/Protenix: A trainable PyTorch reproduction of AlphaFold 3. A trainable PyTorch reproduction of AlphaFold 3. Contribute to bytedance/Protenix development by creating an account on GitHub.

Protenix, the AF3 reproduction made by TikTok's parent company ByteDance, is now available for commercial use with an Apache 2.0 license