Manpreet Mundi

Dr. Mundi @mmundi.bsky.social presenting about GLP-1 at the annual KYSPEN meeting.

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes | NEJM Orforglipron is a small-molecule, nonpeptide glucagon-like peptide-1 (GLP-1) receptor agonist in clinical development for type 2 diabetes and weight management. Additional data on the efficacy and ...

Orforglipron, small molecule GLP-1ra in type 2 #diabetes.
➡️mean HbA1c at baseline was 8.0%. At week 40, it dropped −1.24% with 3-mg, −1.47 % with 12-mg, −1.48 % with 36-mg dose, and −0.41 % with placebo.

www.nejm.org/doi/full/10....

#ADA2025

A consequence of climate change being worsening sleep apnea is something I never even considered. 🍎🧪

Coadministered Cagrilintide and Semaglutide in Adults with Overweight or Obesity | NEJM Semaglutide at a dose of 2.4 mg has established weight-loss and cardiovascular benefits, and cagrilintide at a dose of 2.4 mg has shown promising results in early-phase trials; the efficacy of the ...

Our toolbox for management of #obesity continues to grow with phase 3 data being released today for the combination of cagrilinitide and semaglutide. Average weight loss for the combined drugs was over 20% and side-effect profile was similar to semaglutide. #Medsky 🧪🍎 www.nejm.org/doi/full/10....

Outstanding review of neuroinflammation and dysfunction in #LongCovid onlinelibrary.wiley.com/doi/full/10....
@virusesimmunity.bsky.social @jannamoen.bsky.social

Protein for strength training? Vegan diet matches meat for muscle gains If you're trying to build muscle, getting enough protein is a must. But does it matter if that protein comes from meat or plants? A new study overturns assumptions.

If you're trying to build muscle, getting enough protein is a must. But does it matter if that protein comes from meat or plants? A new study overturns assumptions.

Semaglutide and Tirzepatide Prescribing for Obesity This study uses data from the US nationwide electronic health record–based Epic Cosmos Dataset to examine prescriptions for semaglutide and tirzepatide, focusing on differences across race, ethnicity,...

Analysis of Epic Cosmos data shows use of semaglutide and tirzepatide continues to increase for management of #Obesity now at 2.3% of eligible adults. Discrepancies in prescribing remain based on race and where you live. #Medsky

jamanetwork.com/journals/jam...

This is such a tremendous loss for nutrition and obesity research. Truly hope you are able to continue your work elsewhere especially in Ultra-processed foods.

Sedentary Behavior and Light-Intensity Physical Activity During Pregnancy and Cardiovascular Health: A Science Advisory From the American Heart Association.

www.ahajournals.org/doi/epub/10....

@ahajournals.bsky.social @ahascience.bsky.social
#CardioSky #MedSky #Circulation

(1/n) Why is it so hard to stop eating when something tastes amazing? Our new @ science.org paper reveals that dopamine helps sustain our drive for tasty treats—and may explain how anti-obesity Ozempic tames those urges. doi.org/10.1126/science.adt0773

Non-caloric sweetener effects on brain appetite regulation in individuals across varying body weights - Nature Metabolism In a randomized, crossover clinical trial in healthy young adults with varying weights, sucralose increased hypothalamic blood flow and its functional connections with brain regions involved in motiva...

Do artificial sweeteners increase our appetite? This study using fMRI seems to show that artificial sweeteners activate key regions of the hypothalamus that regulate appetite. #Medsky #Obesity 🧪🍎
www.nature.com/articles/s42...

Gigantic birth study paints most detailed picture of pregnancy’s toll on body Data from 300,000 births reveal how essential biological measurements are altered by carrying and delivering a baby.

This is such an amazing study. Researchers tracked people over 300,000 births looking at how biomarkers change & recover postpartum. ~60% stabilise close to pre-conception levels after 3 months, but some (eg for bone & liver health) take a year. Others never recover! 🧪 www.nature.com/articles/d41...

Lifetime Health Effects and Cost-Effectiveness of Tirzepatide and Semaglutide in US Adults This study compares the cost-effectiveness of 4 antiobesity medications (naltrexone-bupropion, phentermine-topiramate, semaglutide, or tirzepatide) with lifestyle modification vs lifestyle modificatio...

Are tirzepatide and semaglutide cost effective? Although they would reduce 20,854 & 19,211 cases of DM2 and 10,655 and 8263 cases of CVD per 100K respectively, their prices would require a 30.5% and 81.9% reduction from current price to be “cost-effective" #Medsky 🧪

jamanetwork.com/journals/jam...

adiposetissue.org: A knowledge portal integrating clinical and experim... www.sciencedirect.com/science/arti... Thanks to the authors for providing a great online tool for the community

The Influence of Obesity on Cancer Jennifer A. Ligibel, MD, from the Dana-Farber Cancer Institute and Harvard Medical School, Boston, explains how obesity influences the risk of developing cancer and how it influences the prognosis of existing cancer.

edhub.ama-assn.org/jn-learning/...

#obesity #oncsky #medsky #cancer

We do see similar rapid weight loss with bariatric surgery. So medication selection, ie the correct medication based on BMI and medical co-morbidities will be key. 🧪 #obesity #Medsky

Great review on cardiovascular fitness. Imagine if VO2 max was a vital sign measured annually. #Nutsky 🧪🍎

Looking forward to ASPEN 2025. See you in Columbus.

Short-chain fatty acids in clinical practice: where are we? : Current Opinion in Clinical Nutrition & Metabolic Care lued dietary substrate. Recent findings SCFAs act systemically through stimulation of G protein receptors (GPRs) and inhibition of histone deacetylases (HDACs). SCFAs cause appetite suppression, re...

Our review on Short chain fatty acids was just published. SCFA were once thought to just influence the gut mucosa locally, but now appear to have systemic effects: immune-modulation, anti-inflammatory, appetite suppression, mitochondrial function, etc.

#MedSky 🍎🧪
journals.lww.com/co-clinicaln...

GLP-1RA Use and Thyroid Cancer Risk This secondary analysis of a target trial emulation of a comparative effectiveness study uses claims data to estimate the risk of incident thyroid cancer in adults with type 2 diabetes starting treatm...

Are GLP-1 receptor agonists associated with higher risk of thyroid cancer. It looks like there is only an increase in the first year most likely due to increased vigilance. Overall no increase compared to other diabetes medications. #Medsky #Obesity 🧪

jamanetwork.com/journals/jam...

Hope to see ongoing research about the impact of microplastics.

Thanks for raising this issue. Really important to set social media curfew before bedtime especially in current political climate. #Medsky 🧪

Sugar-sweetened beverages are associated with an increased risk of Type 2 diabetes. Now we may know why.
Changes in the gut microbiome and its metabolites
www.cell.com/cell-metabol...

Select microbial metabolites in the small intestinal lumen regulates vagal activity via receptor-mediated signaling Neuroscience; Microbiome

Delighted to highlight new work by Kelly Jameson and colleagues showing that select microbial metabolites in the small intestinal lumen regulate vagal activity
www.cell.com/iscience/ful...

Semaglutide in patients with overweight or obesity and chronic kidney disease without diabetes: a randomized double-blind placebo-controlled clinical trial - PubMed Semaglutide reduces albuminuria and the risk of kidney disease progression in patients with type 2 diabetes and chronic kidney disease (CKD). We conducted a randomized placebo-controlled double-blind ...

📣 Semaglutide in patients with overweight or obesity and chronic kidney disease without diabetes: a randomized double-blind placebo-clinical trial @naturemedicine.bsky.social 👩‍🔬🥼🧪👨‍🔬 #Semaglutide #KidneyDisease #Obesity #kidney #NephroSky #CardioSky #NephSky 👇👇👇
pubmed.ncbi.nlm.nih.gov/39455729/

Mapping the effectiveness and risks of GLP-1 receptor agonists - Nature Medicine An atlas of the associations between the use of GLP-1 receptor agonists (GLP-1RAs) and 175 health outcomes reports the effectiveness and risks of GLP-1RAs compared with other antihyperglycemic medicat...

More real world data regarding benefits and side effects of GLP-1 agonists. Used VA database to compare patients w/ DM who used GLP-1 versus other meds. In addition to cardiometabolic benefits, also reduced substance abuse, psychotic disorders. #obesity #Medsky 🧪

www.nature.com/articles/s41...

#IDSky: Infectious diseases & malnutrition exist within a vicious cycle.

The lowered immunity brought about by malnutrition makes people more vulnerable to disease, while the higher energy requirements and reduced appetite associated with many infectious diseases increase the risk of malnutrition.

Just incredible.