Martin Ott lab

A molecular switch at the yeast mitoribosomal tunnel exit controls cytochrome b synthesis Abstract. Mitochondrial gene expression needs to be balanced with cytosolic translation to produce oxidative phosphorylation complexes. In yeast, translati

In a new study by our @pelleeas.bsky.social, we reveal how Mrx4 organizes translational regulation of cytochrome b synthesis at the mitoribosomal tunnel exit. Thanks @kawresearch.bsky.social for funding and @stirlingchurchman.bsky.social for the fun collaboration! academic.oup.com/nar/article/...

18.07.2025 07:37 — 👍 12    🔁 8    💬 0    📌 1

We just returned from a great retreat with the @osman-lab.bsky.social in the Austrian alps. Intensive scientific discussions on mitochondrial gene expression, fun people, delicious food and great scenery, thank you so much everyone!

18.06.2025 14:13 — 👍 2    🔁 0    💬 0    📌 0

Small molecules restore mutant mitochondrial DNA polymerase activity - Nature An activator of DNA polymerase γ restores function to disease-causing mutant variants and demonstrates a potential route to treatments for inherited mitochondrial disorders involving POLG mutations.

New paper out from the Falkenberg and Gustafsson labs. Thanks to Pretzel for a successful collaboration.
www.nature.com/articles/s41...

09.04.2025 16:30 — 👍 25    🔁 13    💬 0    📌 1

The final version of our work on the in-cell architecture of the mitochondrial respiratory chain is now online in @science.org 🎉
You can find the full story here www.science.org/doi/10.1126/...
@verenaresch.bsky.social did a wonderful job on the cover and animation, she really brought it to life 👩‍🎨

20.03.2025 18:20 — 👍 277    🔁 86    💬 12    📌 7

We're on the cover of @science.org this week. Awesome work by @florentwaltz.bsky.social. #CryoET is reaching crazy resolutions inside cells, and this is just the beginning. Fantastic interpretation of the proton motive force by @verenaresch.bsky.social. Always a pleasure making #SciArt with you!🧪🧶🧬🌾

20.03.2025 22:37 — 👍 309    🔁 69    💬 16    📌 2

Postdoc on Mitochondrial Biogenesis and Quality Control - Gothenburg (Stad), Västra Götaland (SE) job with University of Gothenburg | 12835658 Investigating the molecular connectivity of mitochondrial gene expression, protein biogenesis and quality control Background: Mitochondria convert ...

Less than a week left to apply to the open post doc position in our lab. Join us in beautiful Gothenburg to work on an exciting project!
www.nature.com/naturecareer...

03.03.2025 11:44 — 👍 7    🔁 6    💬 0    📌 1

Postdoc on Mitochondrial Biogenesis and Quality Control - Gothenburg (Stad), Västra Götaland (SE) job with University of Gothenburg | 12835658 Investigating the molecular connectivity of mitochondrial gene expression, protein biogenesis and quality control Background: Mitochondria convert ...

We have an open Postdoc position!
Join our lab in Gothenburg at the beautiful west coast of Sweden to work on an exciting project:
www.nature.com/naturecareer...

04.02.2025 10:10 — 👍 0    🔁 3    💬 0    📌 0

Mechanism of chaperone recruitment and retention on mitochondrial precursors | Molecular Biology of the Cell Nearly all mitochondrial proteins are imported into mitochondria from the cytosol. How nascent mitochondrial precursors acquire and sustain import-competence in the cytosol under normal and stress con...

A new fundamental paper from Manu Hegde´s group: Mechanism of chaperone recruitment and retention on mitochondrial precursors
www.molbiolcell.org/doi/10.1091/...

30.01.2025 11:03 — 👍 2    🔁 0    💬 0    📌 0