Martin Ott lab

Translational activators align mRNAs at the small mitoribosomal subunit for translation initiation Nature Structural & Molecular Biology - Mitochondrial translational activators (TAs) facilitate transcript-specific translation. Using selective ribosome profiling and cryo-electron microscopy,...

Our study on the molecular function of translational activators for mitochondrial protein synthesis is published:
rdcu.be/eSWxT
A great collaboration with @stirlingchurchman.bsky.social and @sshaolab.bsky.social with structural work from our @pelleeas.bsky.social
Funded by @kawresearch.bsky.social

03.12.2025 13:39 — 👍 21    🔁 11    💬 0    📌 1

Online now - the Review "Interconnectivity of mitochondrial protein biogenesis and quality control" from @mitolab.bsky.social et al.

#ProteinImport #Proteaes #Proteolysis #Proteostasis

Read it here: authors.elsevier.com/sd/article/S...

10.10.2025 15:55 — 👍 16    🔁 11    💬 0    📌 0

Ribonucleotide incorporation into mitochondrial DNA drives inflammation - Nature Imbalanced nucleotide metabolism leads to age- and mtDNA-dependent inflammatory responses and senescence-associated secretory phenotype in senescence.

📢 Publication Alert: We're excited to share a new study from the Langer Lab published in @nature.com! It uncovers how an excess of RNA building blocks can destabilize mitochondrial DNA, which plays a role in age-related inflammation.

www.nature.com/articles/s41...

24.09.2025 15:40 — 👍 16    🔁 6    💬 0    📌 0

HuD controls widespread RNA stability to drive neuronal activity-dependent responses Neuronal activity shapes brain development and refines synaptic connectivity in part through dynamic changes in gene expression. While activity-regulated transcriptional programs have been extensively...

Our new pre-print from the Greenberg and Churchman labs shows that activity-dependent modulation of RNA stability is a major, and underappreciated, mechanism of gene regulation in neurons. Tutorial below! www.biorxiv.org/content/10.1... (1/11)

09.09.2025 14:41 — 👍 66    🔁 22    💬 1    📌 1

Our new study in collaboration with the labs of Toni Barrientos (Miami) and Henning Urlaub (Göttingen) on late stages of mitoribosome assembly in yeast. Cryo-EM by our former PhD student Sorbhi and Julian from scilifelab. Funding by
@kawresearch.bsky.social
authors.elsevier.com/c/1liOmc5IDu...

02.09.2025 11:02 — 👍 4    🔁 2    💬 0    📌 0

A molecular switch at the yeast mitoribosomal tunnel exit controls cytochrome b synthesis Abstract. Mitochondrial gene expression needs to be balanced with cytosolic translation to produce oxidative phosphorylation complexes. In yeast, translati

In a new study by our @pelleeas.bsky.social, we reveal how Mrx4 organizes translational regulation of cytochrome b synthesis at the mitoribosomal tunnel exit. Thanks @kawresearch.bsky.social for funding and @stirlingchurchman.bsky.social for the fun collaboration! academic.oup.com/nar/article/...

18.07.2025 07:37 — 👍 12    🔁 8    💬 0    📌 1

We just returned from a great retreat with the @osman-lab.bsky.social in the Austrian alps. Intensive scientific discussions on mitochondrial gene expression, fun people, delicious food and great scenery, thank you so much everyone!

18.06.2025 14:13 — 👍 3    🔁 0    💬 0    📌 0

Small molecules restore mutant mitochondrial DNA polymerase activity - Nature An activator of DNA polymerase γ restores function to disease-causing mutant variants and demonstrates a potential route to treatments for inherited mitochondrial disorders involving POLG mutations.

New paper out from the Falkenberg and Gustafsson labs. Thanks to Pretzel for a successful collaboration.
www.nature.com/articles/s41...

09.04.2025 16:30 — 👍 26    🔁 13    💬 0    📌 1

The final version of our work on the in-cell architecture of the mitochondrial respiratory chain is now online in @science.org 🎉
You can find the full story here www.science.org/doi/10.1126/...
@verenaresch.bsky.social did a wonderful job on the cover and animation, she really brought it to life 👩‍🎨

20.03.2025 18:20 — 👍 278    🔁 87    💬 12    📌 6

We're on the cover of @science.org this week. Awesome work by @florentwaltz.bsky.social. #CryoET is reaching crazy resolutions inside cells, and this is just the beginning. Fantastic interpretation of the proton motive force by @verenaresch.bsky.social. Always a pleasure making #SciArt with you!🧪🧶🧬🌾

20.03.2025 22:37 — 👍 309    🔁 69    💬 16    📌 2

Postdoc on Mitochondrial Biogenesis and Quality Control - Gothenburg (Stad), Västra Götaland (SE) job with University of Gothenburg | 12835658 Investigating the molecular connectivity of mitochondrial gene expression, protein biogenesis and quality control Background: Mitochondria convert ...

Less than a week left to apply to the open post doc position in our lab. Join us in beautiful Gothenburg to work on an exciting project!
www.nature.com/naturecareer...

03.03.2025 11:44 — 👍 7    🔁 6    💬 0    📌 1

Postdoc on Mitochondrial Biogenesis and Quality Control - Gothenburg (Stad), Västra Götaland (SE) job with University of Gothenburg | 12835658 Investigating the molecular connectivity of mitochondrial gene expression, protein biogenesis and quality control Background: Mitochondria convert ...

We have an open Postdoc position!
Join our lab in Gothenburg at the beautiful west coast of Sweden to work on an exciting project:
www.nature.com/naturecareer...

04.02.2025 10:10 — 👍 0    🔁 3    💬 0    📌 0

Mechanism of chaperone recruitment and retention on mitochondrial precursors | Molecular Biology of the Cell Nearly all mitochondrial proteins are imported into mitochondria from the cytosol. How nascent mitochondrial precursors acquire and sustain import-competence in the cytosol under normal and stress con...

A new fundamental paper from Manu Hegde´s group: Mechanism of chaperone recruitment and retention on mitochondrial precursors
www.molbiolcell.org/doi/10.1091/...

30.01.2025 11:03 — 👍 2    🔁 0    💬 0    📌 0