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Debora Gisch

@dlgisch.bsky.social

πŸ”¬ Assistant Research Professor @ IU School of Medicine | Division of Clinical Pharmacology I am a bioinformatician specializing in snRNA-seq, scATAC-seq, and DNA methylation analysis to understand biomolecular changes during DDI trials.

122 Followers  |  409 Following  |  3 Posts  |  Joined: 01.05.2024
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Posts by Debora Gisch (@dlgisch.bsky.social)

Proud to share that our human clinical trial on CBD and immune function is now published!
Led by Dr. Michael Eadon (Clinical Pharmacology Division, Indiana University School of Medicine) and honored to contribute as author.
This is the 5th paper from this clinical trial.

21.01.2026 01:50 β€” πŸ‘ 3    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

🚨 Preprint Alert! 🚨

We’re thrilled to share our long-awaited #Atlas 2.0 manuscript:
β€œCellular and Spatial Drivers of Unresolved Injury and Functional Decline in the Human Kidney” is now live on bioRxiv!

πŸ“„ Read the full preprint: www.biorxiv.org/content/10.1...

29.09.2025 14:51 β€” πŸ‘ 2    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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Integration of spatial protein imaging and transcriptomics in the human kidney tracks the regenerative potential of proximal tubules The interplay in expression of the stem cell markers THY1 and PROM1 in kidney proximal tubules marks the timeline of disease.

πŸ“‘ Need something to read this weekend? If so, you're in luck!

"Integration of spatial protein imaging and transcriptomics in the human kidney tracks the regenerative potential of proximal tubules" fueled by #KPMP investigators is hot off the press today @science.org

www.science.org/doi/10.1126/...

15.08.2025 20:14 β€” πŸ‘ 12    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0
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Cannabidiol exerts anti-inflammatory effects but maintains T effector memory cell differentiation: A Single-Cell Study in Humans Cannabidiol is widely available and often used for pain management. Individuals with kidney disease or renal allografts have limited analgesia options. We conducted a Phase 1 human study to compare th...

What does CBD really do to the immune system in humans?

🧬 We gave healthy adults oral cannabidiol oil.
πŸ“‰ Lymphocyte proliferation dropped.
πŸ”₯ Inflammatory signals shifted.
πŸ’‘ T effector memory cells expanded.

Preprint out now:
πŸ”— www.biorxiv.org/content/10.1...
#CBD #scRNAseq #Immunology #pk

05.08.2025 01:07 β€” πŸ‘ 4    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Human Cell Atlas Creative Commission for the Tomorrow Gallery [Notice] Introduction : Tomorrow: The Bennett Gallery will be the Science Museum's new landmark gallery expl... A Tender Notice by Science Museum Group. Value Β£0-Β£100K.

Are you an artist inspired by the world of biology? The Science Museum in London is inviting proposals for an art commission that will explore and showcase the themes raised by the Human Cell Atlas. Find out more:

07.03.2025 16:10 β€” πŸ‘ 5    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Atlases galore: where to next? - Nature Methods Hundreds of researchers collaborate on maps of the human body and the subcellular realm. As they scout out their next mapping expeditions, they take stock of atlas-making.

Atlases galore: where to next
πŸ§ͺ
www.nature.com/articles/s41...

07.12.2024 06:11 β€” πŸ‘ 10    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0
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Last day at Kidney Week! Thank you for all the opportunities to learn and exchange experiences! #KidneyWk San Diego, CA 2024

Hope to see you all next year in Houston, TX!"

27.10.2024 16:28 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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A MEF2C transcripton factor network regulates proliferation of glomerular endothelial cells in diabetic kidney disease https://www.biorxiv.org/content/10.1101/2024.09.27.615250v1 Background: The maintenance of a healthy epithelial-endothelial juxtaposition requires cross-talk wi

A MEF2C transcripton factor network regulates proliferation of glomerular endothelial cells in diabetic kidney disease https://www.biorxiv.org/content/10.1101/2024.09.27.615250v1

30.09.2024 17:30 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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A MEF2C transcripton factor network regulates proliferation of glomerular endothelial cells in diabetic kidney disease https://www.biorxiv.org/content/10.1101/2024.09.27.615250v1 Background: The maintenance of a healthy epithelial-endothelial juxtaposition requires cross-talk wi

A MEF2C transcripton factor network regulates proliferation of glomerular endothelial cells in diabetic kidney disease https://www.biorxiv.org/content/10.1101/2024.09.27.615250v1

30.09.2024 17:30 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0