Andreas Schoenit

Mapping cell dynamics in human ex vivo hair follicles suggests pulling mechanism of hair growth - Nature Communications The authors use 3D live imaging on micro-dissected human hair follicle segments cultured ex vivo to follow cellular migration patterns with single cell resolution. They provide evidence suggesting an ...

So proud to share this beautiful work developed in collaboration with @lorealfrance.bsky.social
Using 3D imaging at an outstanding level of resolution, we have uncovered the intricate cellular dynamics of human hair follicles - and the movies are stunning!
More details here: tinyurl.com/4vrywf3z

Are you investigating cell tissues and interested in stress patterns? TFM + BISM reveals them! 👇

With @luanger.bsky.social and P. Marcq, we summarise the applicability across different exp. conditions regularly used in the @bladoux.bsky.social @rmmege.bsky.social lab.
Full pipeline on Lucas GitHub!

The latest story from my group. Working toward build regionally distinct skin and amnion piece by piece.

Thank you!

I would like to sincerely thank everyone involved from our group @ijmonod.bsky.social as well as A. Doostmohammadis. And of course not only related to this project @rmmege.bsky.social and @bladoux.bsky.social for their constant support and mentorship!

Photo credit: Mathieu Baumer

Truly honoured and grateful to have received alongside other young researchers the prize "Grandes avancées françaises en biologie" from the @academiesciences.bsky.social for our paper on mechanical cell competition together with @luanger.bsky.social and S. Monfared www.nature.com/articles/s41...

Exciting News! 🥳 Our Epithelial Mechanics Fan Club website is now live! 🎉
👉 epithelialmechanics.github.io

Discover our #EpithelialMechanics threads and get to know our amazing delegates behind them.
Would you like to share your story? Please DM us!

1/ 🎉Excited to share our new preprint @vignjeviclab.bsky.social @davidbrueckner.bsky.social :

"Self-organization of tumor heterogeneity and plasticity"
biorxiv.org/content/10.1...

Tumor heterogeneity and plasticity drive metastasis and relapse. How is tumor patterning coordinated?

A thread👇

Happy to share the last version of our story @currentbiology.bsky.social on the role of interfacial tension in mechanical cell competition led by @leovalon.bsky.social and Alexis Matamoro Vidal
www.sciencedirect.com/science/arti...

Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.

How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇

Can pressure gradients persist over long timescales in animal cells? We induced intracellular pressure gradients and examined the resulting flows in single cells. We reveal surprisingly long lasting pressure gradients.

More here: elifesciences.org/reviewed-pre...

Now out in final published form - with a new title "Mechanical control of cell fate decisions in the skin epidermis" and simulations/quantifications! See below for thread of how unbalanced tensions can bias fate choices in minimal 3D models of tissues! www.nature.com/articles/s41...

A ring of cells deforms into a triangular keyhole in just 15 minutes. Meet the hindgut, a model for boundary-driven morphogenesis!

Out now in @pnas.org at doi.org/10.1073/pnas... with @zhaoshh.bsky.social, Alex Jacinto, Eric Wieschaus, Stas Shvartsman, @lepuslapis.bsky.social (1/8)

How is developmental speed regulated ? 🪰

Happy to share my PhD story from Schweisguth Lab @devstempasteur.bsky.social. Here we show that cellular NAD+ availability and redox constrain developmental speed in the fly eye.

www.biorxiv.org/content/10.1...

A big thanks to everyone involved!

We’re organizing a conference at @ijmonod.bsky.social in Paris, January 2026, in memory of M.P. Sheetz — pioneer in cell mechanics and mechanobiology, co-discoverer of kinesin, and founder of @mbisg.bsky.social. Join us to explore his legacy.

mikeinmemoriam.sciencesconf.org

Regulation of epithelial tissue homeostasis by active trans-epithelial transport Epithelia are intricate tissues whose function is intimately linked to mechanics. While mechanobiology has primarily focused on factors such as cell-generated contractility and mechanical properties o...

Happy to share our new study @ijmonod.bsky.social and @mpi-scienceoflight.bsky.social with C. Duclut and J. Prost. on forces generated by active fluid transport in epithelia and their role in tissue dynamics.
Congrats to Huiqiong Wu, G. Arkowitz and R. Chilupuri!
www.biorxiv.org/content/10.1...

The complex microscopic dynamics of cells in high-density epithelial tissues Epithelial tissues line the surfaces of vital organs and are often densely packed in a disordered, mechanically arrested state, referred to as jammed or glassy state. While collective migration at low...

Very happy to share our new study from CAM team @ijmonod.bsky.social and @mpi-scienceoflight.bsky.social (MPZPM) on the unanticipated “hidden fluidity” in jammed epithelia. Congrats to Yuan Shen and great collaboration with Walter Kob.
www.biorxiv.org/content/10.1...

Epithelial tension controls intestinal cell extrusion Cell extrusion is essential for homeostatic self-renewal of the intestinal epithelium. Extrusion is thought to be triggered by crowding-induced compression of cells at the intestinal villus tip. In th...

Out in @science.org! We found that the intestine doesn’t just push out cells when crowded. Instead, cells are in a mechanical tug-of-war, and weaker ones are extruded. A new view of how our gut keeps its balance and stays healthy.
www.science.org/doi/10.1126/...

Are different cell types like oil and water? Over a century ago, researchers found that dissociated sponges and embryonic tissues can self-assemble into functional structures. Join me, @benswedlund.bsky.social to explore the differential adhesion hypothesis & its applications in tissue engineering!

Excited for my thesis defence, join us for a discussion on the role of mechanical forces in building and maintaining epithelial tissues if you happen to be in Paris in September!

📢 Institut Jacques Monod Seminar

📅 September 11th
📍 Institut Jacques Monod

Invited by @bladoux.bsky.social / @rmmege.bsky.social 's Lab , Stephanie Ellis ( @maxperutzlabs.bsky.social ) give the IJM Seminar "Understanding mosaic tissue dynamics through cell competition. "

➡️ buff.ly/V6LaKMz

Now published in @natcomms.nature.com! 🥳

👉 rdcu.be/eATn3

We developed image analysis tools to capture the nematic orientation field of 3D tissue surfaces. Tested on epithelial aggregates, zebrafish hearts, myoblasts on spheres & micro-vessels, we combined soft matter physics with exp. biology.

RAB5A Promotes Active Fluid Wetting by Reprogramming Breast Cancer Spheroid Mechanics RAB5A-mediated unjamming enhances active wetting through distinct biomechanical processes: a) upregulation of specific integrin subunits, enhanced focal adhesions kinetics and activity; b) supracellu...

🚀 New in Advanced Science: RAB5A drives active fluid wetting in breast cancer spheroids by reprogramming cell mechanics.

doi.org/10.1002/advs...

👏 Kudos to first author Grégoire Lemahieu and our amazing co-authors for this joint effort!

#CancerMechanobiology #CellAdhesion #RAB5A #TeamScience

Start-Shape-Stop: Cell communication mechanisms controlling organ size Accurate growth control is critical for the achievement of proportional organs during animal development and repair processes. Either extra or deficie…

Hot off the press!!! Proudly presenting our lab's new review on how do cells communicate to control organ size :) We focus specially on dynamic connections that operate at different timescales to regulate organ growth and morphogenesis. #devbio #SizeandShape www.sciencedirect.com/science/arti...

Thrilled to share the first story from my postdoc! 🎉 A wonderful experiment + simulations collaboration. In the Drosophila wing, we find that 3D cell shapes affect signalling range and fine-tune developmental patterning www.biorxiv.org/content/10.1... Thread below ⬇️

Cytoplasmic crowding acts as a porous medium reducing macromolecule diffusion Intracellular transport of macromolecules is crucial for the proper functioning of most cellular processes. Although intracellular crowding is known to strongly alter macromolecule mobility, how cytop...

To what extent does crowding modulate diffusion across the cytoplasm?
Thrilled to contribute to this study alongside O. Destrian, M. Chabanon, and B. Goyeau!
www.biorxiv.org/content/10.1...

Preprint by @towalther.bsky.social at al! We design DNA hydrogel microparticles with sequence-controlled stiffness from 30 Pa to 6.5 kPa. They are remodelled in fibroblast spheroids www.biorxiv.org/content/10.1... Thanks @ibecbarcelona.eu @xaviertrepat.bsky.social @pcusachs.bsky.social

On cell extrusion in the #intestine!
After 80 years of observations, we finally took a deeper look thanks to 2D #organoids. We report:

3D #forces, #extrusion still only in the villus even without curvature, #lamellipodia generate 3D force.. and more. Have a look!
www.biorxiv.org/content/10.1...

Congrats to @luanger.bsky.social and @andreasschoenit.bsky.social for receiving the prestigious 'Les Grandes Avancées en Biologie' award 🏅 from the @academiesciences.bsky.social !

What do we see when looking at cells under the microscope? 👉Some are bigger than others, some are elongated and align with the neighbors & others seem to move. Cool, right? But wouldn't it be cooler to quantify these observations?

I'm @juliaeckert.bsky.social. Let's explore some analysis software!‬