Ryan West

I'm looking forward to discussing our work at Tambourine’s ALS Breakthrough Research Fund investigators meeting this week. A pretty good view from my room

taking a break from all the hills and letting the 5 yo loose down the monsal trail

Scott Allen and myself have an opportunity for a postdoc working on pyruvate metabolism in normoxia and hypoxia using a combination of C9orf72 patient-derived iNPC and Drosophila models. Based at SITraN (sheffield.ac.uk/sitran)

jobsite.sheffield.ac.uk/job/Research...

Check out our new #neuroscience @BiologyatYork banner to showcase our diverse, multidisciplinary, multi model, and so much fun research environment that you could be in by joining us as an under or postgrad
york.ac.uk/study/undergra… or/and postgrad too!

i'm not cheap

🚀 Hot off the press! Our team findings @livuni-ismib.bsky.social on brain ageing unveil a novel connection between oxidative stress, neuronal microtubules, and the cytoskeletal protein EB1 driving neuronal atrophy. 🎉 A huge thank you to the fantastic team!
www.aginganddisease.org/EN/10.14336/...

oh ChatGPT what monstrosity is this?

There are some hills over there somewhere!

my email inbox is like my snail mail postbox. The mail can be there whenever you want it to be but I will deal with it in my own sweet time depending on which mail looks most/least interesting to me.

This image shows the Sheffield Instiute for Translational Neuroscience (SiTraN) building at sunrise, with the sky transitioning from vibrant orange and pink near the horizon to darker blue at the top. The "SiTraN" sign is an integral part of the building's architecture, made of large metallic letters that appear to support the roof. Behind the sign is a wooden facade. The surrounding area includes bare trees silhouetted against the colorful sky and softly lit pathways leading to the building

Clear skies over SITraN this morning

This image depicts a wooden table with a bottle of Lagavulin 8 Year Old Scotch Whisky, a glass, a white plate holding a single mince pie, and a small carrot placed beside the plate

I think santa will enjoy the whisky the 4 year old left for him 👀

23 pairs

of course, i'm not a monster!

A group of hikers walking uphill on a muddy and rocky path in an open countryside setting. The foreground shows patches of grass, stones, and puddles, while the background features a scenic view of rolling green fields, winding trails, and distant hills under a cloudy sky with hints of blue. The hikers are dressed warmly in winter jackets, hats, and scarves,

A group of nine people dressed in winter clothing, including hats, scarves, and jackets, posing outdoors on lose hill (peak district) with a cloudy sky in the background. The landscape features rolling hills and valleys.

a slightly chilly lab walk in the peaks

A handmade birthday card. The design features colorful balloons at the top with the letters of "HAPPY BIRTHDAY" written inside them. Below the balloons, the name "RYAN" is prominently displayed in bold, patterned letters. In the center, there’s a humorous drawing of a fruit fly wearing a green hat and leaning on a walking stick

A birthday card from the lab. A @comeflywithjo.bsky.social special. I wonder what they are trying to imply?

Poster session B, 5.30-7 7th December

RuvBL1/2 reduce toxic dipeptide repeat protein burden in multiple models of C9orf72-ALS/FTD A G4C2 hexanucleotide repeat expansion in C9orf72 is the most common cause of amyotrophic lateral sclerosis and frontotemporal dementia (C9ALS/FTD). Bidirectional transcription and subsequent repeat-a...

I am pleased we were able to help with this nice paper showing RuvBL1/2 can reduce DPR abundance and reduce phenotypes observed in our fly models
www.life-science-alliance.org/content/8/2/...

For anyone heading to #alsmndsymp in montreal look out for @mndassoc.bsky.social funded student Charlotte Gale-Rogers work on C9orf72 DPR disruption to locomotor rhythmicity using some of our fly models. Poster IVV-26.

i see you have moody skies too
bsky.app/profile/west...

sunrise showing a sky filled with dramatic clouds illuminated in shades of orange, pink, and red, contrasting against a pale blue sky. In the foreground, silhouettes of tree branches, a utility pole, and buildings are visible. The cityscape of Sheffield is visible below the horizon

striking views from my office this morning

I just found myself looking at it and losing any hope for humanity. This is better for my sanity

twitter account deactivated. It's bluesky only now

Cloud of words in various colors and sizes based on a Google Scholar profile. Some of the largest words include drosophila dementia frontotemporal models disease regulate toxicity activity-dependent chmp2b growth identification model neuronal oxygen parkinson’s plasticity rab8 reactive species using amyotrophic animal c9orf72 conserved dysfunction genetic ik2tbk1 jnk lateral mediates

Cloud of words in various colors and sizes. Some of the largest words include drosophila models function repeat ftd synaptic mutation disease genetic mutant neurons kinase als c9orf72 dementia toxicity chmp2b flies length mutants

Google scholar vs pubmed wordclouds

🧠Sharing this Starter Pack again as the list has now reached 80 people! A great mix of Profs/PIs/Post-docs/PhDs/Technicians.

Please re-post so it can reach a wider audience as I'm sure there are more of us out there ☺️🦋

go.bsky.app/S6FfsTp

This is not the greatest pint in the world, no this is just a ...

a quick trip down to London for a grant panel and to say hello to some old friends

back from a very enjoyable @nc3rs.bsky.social Partnership and Impact panel meeting. Lots of great science. Looking forward to seeing some of those projects going forward.

i show this to everyone in my lab. We've started using superplots to show individual Drosophila overlayed with the mean of the individual experimental cross (true biological replicate)

Green, M. M. (2010) 2010: A century of #Drosophila genetics through the prism of the 'white' gene. Genetics 184, 3-7 — www.ncbi.nlm.nih.gov/pubmed/20061...