Max Heiman

why do you say it is more common?

and here I thought that was from Johnny Cash! genius.com/Johnny-cash-...

Second that!

sorry that went right over my squid-like head the first time

I received this in Aug 2011. We still found ways to write nonsense before AI!

The other five are pretty amazing too!!

Before LLMs we still got many copy-paste materials! My favorite was a CV that started "My squid-like head is a masterful problem solver and I hope that I can bring world domination to your organization." If you google the first phrase you can find dozens! They unwittingly copied a joke C'thulhu CV.

in other news my final exam questions are ready earlier than ever before

The key to getting any task done is having another task that you want to do even less.

our top choice (for ease and convenience, not gold standard) for C. elegans proteins is still expressing tagged versions in S2 cells (which grow 20-25°C) and co-IP, combined with some in vivo evidence like colocalization, localization of A depends on B, etc

So proud of my newest lab member!

This all makes sense to me except (1) the tants should go higher and (2) what does it need with pockets??

Movie scene, riding the luck dragon Falkor from The Never Ending Story

Falkor?

#aECM Cub starts next week Nov 18 with talks on patterning the Drosophila lens, mouse tectorial membrane, and C.elegans cuticle furrows. You can still sign up for access using the link below.

where is the Brownian ratchet??

High-efficiency targeted integration of extrachromosomal arrays in C. elegans using PhiC31 integrase https://www.biorxiv.org/content/10.1101/2025.11.11.687718v1

Graphical summary representing strategies for deciphering temporal–spatial phosphoproteomic outcomes of primary cilia signaling in different biological contexts.

In this Opinion piece, Rachel Turn, Mohammad Ovais Aziz-Zanjani, Anushweta Asthana & Peter Jackson highlight strategies for multiplexing diverse approaches to map transient phosphorylations driving ciliary function & G0 in health versus disease.
#JCSciliaSI
journals.biologists.com/jcs/article/...

Wut.

A.I. is to intelligence what a scarecrow is to a human. Sure, some birds might confuse them, but that does not make them the same.

I agree, I think CGC dues us probably the best proxy - hadn't thought of that before

that's good as a high end probably, I think that's more like all the labs that have ever been (minus a smaller number without lab codes). consistent with a guess of around 500-800ish currently?

That's about what I guesstimated but nice to hear you thinking that way too. I got there because I think I remember there were ~200ish R01s ~ten years ago (before R35 shift), some people had more than one, some had NSF/other, many non-US, but ~500-750 (1000 at high end) seemed like a good guess.

Not sure - paper, preprint, or research grant (incl. startup) in last 5 years?

I guess CGC annual dues could be a good estimate too.

How many (active) C. elegans labs are there?

I mean, it's pretty clear. It refers to peer review members disclosing any information about the applications being reviewed.

It's clearly not limiting the guidance NIH can provide or the general freedom of people to complain about typos etc as long as it's not connected to the apps they review.

In my view it's 100% a breach of confidentiality and review integrity.

"Confidentiality in NIH peer review prohibits a peer reviewer member from: [...]
Disclosing, **in any manner**, information about the committee deliberations, discussions, evaluations, or documents [...]"

emphasis added

I thought the "most dangerous animal in the world" was us!

From the lab of Maxwell Heiman discussing the interesting topic of apical ECM and the function of sensing organs and how these ECM proteins can both mechanically and biochemically modulate the organ's functions.
doi.org/10.1016/j.cd...

The ECM is no longer in the back seat when it comes to development. Check out our special issue "Dynamics of the extracellular matrix in development, cell physiology and disease" with 8 selected articles to learn more: A 🧵 www.sciencedirect.com/special-issu...

A CRISPR activation screen reveals a cilia disassembly pathway mutated in focal cortical dysplasia A gain-of-function screen uncovers a cilia disassembly pathway linked to genes somatically mutated in neurodevelopmental disease.

Excited to share our latest work on a new cilia disassembly pathway and a link between this pathway and the neurological disorder focal cortical dysplasia: www.science.org/doi/10.1126/...
Brief summary: we used a genome-wide CRISPRa GOF screen to identify negative regulators of ciliary signaling...

Micropublication @micropub7n.bsky.social is peer reviewed and PubMed indexed. A great way to get the data out in uncertain times
👇🏼