Aideen Ryan, BSc, PhD

Researchers at the University of Galway have revealed the results of a world-first study into how bowel cancer shuts down the immune system, and how this can be reversed to improve treatment. 🧬

Read more 👉 https://jitc.bmj.com/lookup/doi/10.1136/jitc-2025-012491

Abstract drop - CT269 - First-in-human trial in patients with metastatic colorectal cancer using CRISPR-engineered tumor infiltrating lymphocytes in which the intracellular immune checkpoint CISH is inhibited #AACR25

eppro02.ativ.me/appinfo.php?... #AACR25

Thrilled to have secured Breakthrough Therapy Designation. This will accelerate our ability to bring #CARTcells to more children with #DIPG and brain & spinal cord tumors.

Last week, the 1st Annual IMPACT conference took place on the shores of Loch Lomond 📍🤩

With 5 distinct research groups led by @joedwardswwcrc.bsky.social, Campbell Roxburgh, Nigel Jamieson, Colin Steele, and @mcsorleystephen.bsky.social, IMPACT provides a human tissue-based translational research infrastructure in Glasgow, in collaboration with @drpipdunne.bsky.social and Xiao Fu! 🤝

Stromal cells modulate innate immune cell phenotype and function in colorectal cancer via the Sialic acid/Siglec axis The immunosuppressive tumour microenvironment (TME) reduces immune response effectiveness in stromal-rich tumours, including CMS4 colorectal cancer (CRC). Mesenchymal stromal cells (MSCs), precursors ...

Our latest story on the impact of the Sia/Siglec axis and stromal cells in colorectal cancer is online - led by Aoise O’Neill. We identified tgat stromal sualylation shaoes innate immune phenotypes and function. www.biorxiv.org/content/10.1...

Congratulations Róisín. Looking forward to reading it.

AACR Legislative Action Center Directly contact your elected officials about the importance of cancer research, the need for continued funding and the latest lifesaving breakthroughs. In the United States, you can do so by sending ...

Kudos to the @theaacr.bsky.social for making it easy to reach out to your representatives. Nice to see courage and action. nam02.safelinks.protection.outlook.com?url=https%3A...

This researcher helps the body help itself in the fight against cancer University of Galway’s Dr Aideen Ryan is looking at mechanisms in supportive tissue cells with the aim of enhancing the body’s immune response to cancers.

@uniofgalway.bsky.social researcher helps the body help itself in the fight against cancer. @aideenryan.bsky.social is looking at mechanisms in supportive tissue cells to enhance the body’s immune response to cancers. tinyurl.com/3x44aa8p

This researcher helps the body help itself in the fight against cancer University of Galway’s Dr Aideen Ryan is looking at mechanisms in supportive tissue cells with the aim of enhancing the body’s immune response to cancers.

University of Galway’s Dr Aideen Ryan is looking at mechanisms in supportive tissue cells to enhance the body’s immune response to cancers.

Failure is always in the background of any creative project; when the experiments are not working or the results don’t seem to make sense. But for discovery, you can’t deny yourself the permission to fail, and we should better teach failure in all its glory.

Grant has been reimagined, rewritten, read by others, revised and submitted! Fingers crossed that it does well. On to the next challenge we go, Sisyphus!

I get knocked down, I get back up again! 💪🏽

Happy Holidays Kristin and team! Looking forward to catching up in 2025!

Great slide highlighting not only are TILs predictive of pCR...it also translates to being prognostic beyond pCR for good outcome and DFS.

Seems like we have a LOT of data on TILs now, why aren't they standardly provided on path reports???🧐

#SABCS24
@oncoalert.bsky.social
@sabcs.bsky.social

Thanks for the updates @bernardafox.bsky.social . Nice to be able to keep up with the highlights though your updates.

#Bridge2024 coming to a close! Saturday, December 7th 2024 @2:10 pm and we are entering the last session/will cover 1st line #immunotherapy, salvage, igniting change in #cancer #vaccine development, combo IO, #PD1 refractory & more @sitcancer.bsky.social #MSD #BIOTECH #BMS #Merck #Regeneron #UbiVac

WORK HARD, PLAY HARD! Celebrate your success & commiserate over failures / #Immunotherapy #Bridge2024 is over & the 15th #Melanoma Bridge has started. Great being in #Napoli with so many friends. PAscierto, Choueiri, Hamid, Tawbi @samirkhleif.bsky.social , Bruno, Guerrero, @sitcancer.bsky.social

Discussion of Prof Mitch Levesque data / Amazing single cell #melanoma phenotypes/ can it explain resistance? Thinks metabolic signature? Functional data more important
#Bridge2024 @melanomaresearch.bsky.social @impactmelanoma.bsky.social @sitcancer.bsky.social #FinishCancer #PAscierto

Prof Michael Postow #melanoma #immunotherapy Expert @mskcancercenter.bsky.social talks #neoadjuvant treatment.. How many doses of checkpoint blockade? Can we reduce toxicity & maintain efficacy? @sitcancer.bsky.social #Bridge2024 @impactmelanoma.bsky.social @melanomaresearch.bsky.social

YouTube video by CUNY Graduate Center City of Science: Katalin Karikó in Conversation with Carl Zimmer

More video! Here's my conversation with Nobel-prize winner Katalin Kariko, who pioneered mRNA vaccines. youtu.be/5_9ccDmX3hs?...

Dual gene set enrichment analysis (dualGSEA); an R function that enables more robust biological discovery and pre-clinical model alignment from transcriptomics data - Scientific Reports Scientific Reports - Dual gene set enrichment analysis (dualGSEA); an R function that enables more robust biological discovery and pre-clinical model alignment from transcriptomics data

Congratulations Sid, Courtney and @drpipdunne.bsky.social on your publication in Scientific Reports- a really useful resource to help the field ensure more robust discovery approach using dualGSEA. @researchireland.bsky.social @universityofgalway.bsky.social

www.nature.com/articles/s41...

We have a great line up and we are super excited by all the abstracts we have recieved!

Register by Dec. 12 (11:59pm MST) to save $200 USD & access 2 meetings for the price of one! Join us in Vancouver in Feb. for the T Cell Differentiation in Tissue Microenvironments Keystone. hubs.la/Q02ZKxQV0

Opinion | Her medical file read 'death imminent.' His treatment plan changed cancer forever. | Opinion — USA TODAY Immunotherapy is the brightest new weapon in fight against cancer. Thank Dr. Steven Rosenberg, who 40 years ago successfully used it to save a life.

💥40 years ago today a 33 y/o dying of #metastatic #melanoma got #LAK & #IL-2 & all #cancer went away! Dr. S.A. #Rosenberg (SAR) had the #immune system #cure a patient/I was in SAR’s lab 85-90/incredible era & energy/Great story in @usatoday.com apple.news/AIcm-M7cDQ-O... @sitcancer.bsky.social

Delighted to celebrate Eileen’s, Aoife’s and Jiemen’s graduations yesterday. Three stellar PhD students who were a pleasure to supervise and work with. Wishing them all of the best in their future careers. @researchireland.bsky.social

Only a subset of patients respond to immunotherapy

Why? Which ones?

We conducted an unbiased analysis of response biomarkers and found that hundreds of possible biomarkers collapse into five latent, orthogonal factors that underlie immunotherapy response.

www.nature.com/articles/s41...

Cancer-associated fibroblasts maintain critical pancreatic cancer cell lipid homeostasis in the tumor microenvironment Han et al. identify crosstalk between CAFs and pancreatic cancer cells under hypoxia and nutrient scarcity. Lysophosphatidylcholines (LPCs), as the key mediators, can be utilized for phosphatidylcholi...

Cancer-associated fibroblasts maintain critical pancreatic cancer cell lipid homeostasis in the tumor microenvironment www.cell.com/cell-reports...

Women are under-represented at senior levels in #academia globally, & across all #science 🧪 disciplines, as shown by these "scissor-shaped curves" ✂️

So how can we ever achieve #gender #equality?

We discuss various strategies in this #Cell Commentary

#WomeninSTEM

www.cell.com/cell/fulltex...
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Focus on research: Prof Sharon Glynn, University of Galway - TechCentral.ie Prof Sharon Glynn is a Professor in Pathology at the University of Galway working with Cúram, the Research Ireland centre for medical devices. In this interview she talks about advancements in the und...

Great article w/ CÚRAM FI Sharon Glynn
at Universityof Galway in TechCentral this week explaining her work on breast cancer and triple negative breast cancer in particular.. Read more at techcentral.ie/focus-on-res... #breastcancerresearch #NOCANCERNETWORK
@researchireland.bsky.social

The hallmarks of cancer immune evasion Cancer cells often evade the host immune system, challenging the effectiveness of immunotherapy. In this comprehensive review, Galassi et al. summarize key mechanisms of immune evasion within the “thr...

The hallmarks of cancer immune evasion

Gliocidin is a nicotinamide-mimetic prodrug that targets glioblastoma - Nature The prodrug gliocidin effectively kills glioblastoma cells by targeting de novo purine synthesis, improving survival in mouse models.

Gliocidin is a nicotinamide-mimetic prodrug that targets glioblastoma - Nature 🧪
www.nature.com/articles/s41...