Helene Schmidt

Connectomics is Method of the Year 2025!!
@natmethods.nature.com
just released the news nature.com/articles/s41... In my perspective piece, I afford some predictions into the future and compare how we are doing vs. genomics www.nature.com/articles/s41...

Connectomic analysis of astrocyte-synapse interactions in the cerebral cortex Astrocytes, a main type of glia cells in the cortex, provide metabolic support to neurons, and their possible function as a synaptic partner has given rise to the notion of “tripartite” synapses, sugg...

Hi, we didnt analyse astrocytes in that dataset. But maybe this helps you further, this study looked at astrocytes in EM data (cortex) www.biorxiv.org/content/10.1...

Thanks! This looks like a glia cell to me, but to be sure one would need to follow it a bit to see if the processes are glia like.

Congrats to Eleonora, Maria and Mourat and thanks to scalableminds and @mhlab.bsky.social for incredible support! @ESI_Frankfurt @mpibrain.bsky.social

Connectomic traces of Hebbian plasticity in the entorhinal-hippocampal system The key model of how we learn and memorize is Hebbian learning in the hippocampus, via long-term potentiation of synapses, allowing the storage of associations, linkage to places, and their consolidat...

…and we used this and our other datasets to sample systematically how a mouse’s memory networks are configured synaptically www.biorxiv.org/content/10.1... . Totally stunned by how special CA1 and CA3 are at the synaptic weight level!

Super happy that our papers #2 and #3 from our 3-person lab just went online on bioRxiv! First large-scale 3D EM dataset from mouse hippocampus CA1 www.biorxiv.org/content/10.1... - check out the beautiful data on webknossos wklink.org/7023 ! …