Lindsey Lammlin

If you are at #ICORS2025🇦🇺🦘, I’d love to see you at my talk in the OA Molecular Biology session starting at 11:15a today, Oct 8th! I’m also super excited to be sharing the session with my friend and fellow UMich lab alum, @jointcrosstalk.bsky.social !

Our paper on enhancing the repair of #RotatorCuff tears using pharmacologic methods to recruit endogenous MSCs is out in AJSM today! The project was fun, but I can't say enough about my amazing co-authors. Read it here:
journals.sagepub.com/doi/10.1177/...

Thanks for showing me around the new lab space and St. Louis!☘️ Exciting things are ahead for the Joint Crosstalk Lab!

CXCL16 mediates nociception and inflammation in murine post-traumatic osteoarthritis This study investigates the role of the chemokine CXCL16 and its receptor, CXCR6, in post-traumatic osteoarthritis (PTOA) and joint nociception, highlighting the potential of targeting the CXCL16-CXCR...

I’m happy to share a recent pre-print of my PhD work looking at the role of CXCL16 in murine joint pain and inflammation! 🐭 If you missed it yesterday, come find me today at #OARSI2025 🇰🇷 poster 614 and we can chat about this exciting study! www.biorxiv.org/content/10.1...

@maerzlab.bsky.social @cdejulius.bsky.social @jointcrosstalk.bsky.social

Come check out work from the Maerz Lab at OARSI 2025! #OARSI2025 🇰🇷

Check out our latest preprint showing promise for treating joint pain @jointsintheworld.bsky.social

Matrix-producing neutrophils populate and shield the skin Nature - A population of neutrophils in the skin produces extracellular matrix, providing a defence strategy by reinforcing the barrier properties of the skin and helping to block the entry of...

Excited to post for the first time to present our exciting new paper @Nature. The fruit of massive work by Tommaso Vicanolo, @alazozcan.bsky.social and Jackson Li, and our superb collaborators Laiguan and Stefan Uderhardt. True teamwork!
Free link: rdcu.be/eeeA2
www.nature.com/articles/s41...

This system, MoJO, while formally know as “Mobile Joint Injury Operator” is lovingly referred to in the lab as the “Mobile Joint Obliterator”😎

A standardized, open-source, portable model for noninvasive joint injury in mice Preclinical models of osteoarthritis (OA) are crucial for the study of disease mechanisms and for the development of critically-needed disease-modifying therapeutics. While surgical OA models, such as the destabilization of the medial meniscus (DMM), have been the gold standard in the field for decades, noninvasive joint loading-based models have increased in popularity and utility. To facilitate standardization of the noninvasive anterior cruciate ligament rupture (ACLR) model in mice, we present the Mobile Joint-Injury Operator (MoJO) - an open-source protocol with accompanying fixtures and data, designed for a low-cost, commercially-available, portable uniaxial testing system with a small footprint. We provide 3d-printable fixture designs and a rapid, highly-repeatable ACLR-mediated joint injury protocol that results in the expected post-traumatic osteoarthritis phenotype in male and female C56Bl/6 mice. We then describe the expected mechanical data from the injury procedure and offer various troubleshooting strategies. Finally, we summarize the resultant PTOA phenotype by knee hyperalgesia testing, μCT imaging, flow cytometry, and histological assessment. Increased standardization of this model is a critical aspect of the overall refinement of animal models of OA. ### Competing Interest Statement The authors have declared no competing interest.

Ending the week with a new Maerz lab preprint! @maerzlab.bsky.social

We present an open source protocol for the ACLR model, with designs for 3D printable fixtures, QC and analysis codes, troubleshooting tips, representative data, and expected phenotyping outcomes.

www.biorxiv.org/content/10.1...

Check out the awesome work from the Maerz Lab at #ORS2025! I’ll be giving my talk on Monday at 3:25p - hope to see you there!

@orssociety.bsky.social

It is almost time for #ORSOpenDoor! Volunteers have arrived, coffee is being served, and workshops are underway 🎉

Follow along here and on Blue Sky to get all the updates today! @orssociety.bsky.social

I know there is a lot going on right now, but I think some happy news is still worth sharing - I will be defending my PhD on March 18th! This has been my most difficult, yet most rewarding journey and I’m incredibly grateful for the support that I have received along the way. DM me for zoom info!

Hi Dr. Pattison, it looks like I can’t DM you directly, but I sent you a message the old fashioned way! By that I mean email📧, and not carrier pigeon🐦

Sign me up!!🤩