Matt Hall

Discovery of a tau-aggregate clearing compound that covalently targets P4HB Conway et al. integrate phenotypic screening with chemoproteomics to discover an aminoindole that potently clears tau aggregates across multiple tauopathy models via covalently targeting of the ER enzyme P4HB, revealing potential therapeutic strategies for neurodegenerative disease.

Online now! Discovery of a tau-aggregate clearing compound that covalently targets P4HB #chembiol

The 2025 chemistry Nobel goes to MOFs Susumu Kitagawa, Richard Robson and Omar M. Yaghi win the prize for developing metal–organic frameworks

MOFs are pretty darn cool. Here's our story, in @cenmag.bsky.social cen.acs.org/people/nobel...

Enhanced PIEZO1 function contributes to the pathogenesis of sickle cell disease | PNAS Sickle cell disease (SCD), an inherited blood disorder caused by a mutation in the β-globin gene, is characterized by sickle erythrocytes that are ...

Our new PNAS paper "Enhanced PIEZO1 function contributes to the pathogenesis of sickle cell disease" is out: www.pnas.org/doi/10.1073/... 1/3

As NIH launches new autism research effort, the focus is on environmental factors The NIH is making a $50 million bet: Understanding environmental factors will help researchers better understand why some people have autism.

Scientists believe factors like diet and chemical exposure could play a role in a condition largely driven by genetics
www.statnews.com/2025/10/03/n...

Ice freshly ejected from Enceladus contains complex organics Reanalyzing data from <i>Cassini</i>'s 2008 flyby reveals new, complex organic molecules in the spray from Saturn’s icy moon

Ice freshly ejected from Enceladus contains complex organics

Reanalyzing data from Cassini's 2008 flyby reveals new, complex organic molecules in the spray from Saturn’s icy moon. cen.acs.org/physical-che... #chemsky 🧪

An astrophysicist explains one of the most famous album covers of all time You've probably seen this album art a million times, but what exactly are those wiggly lines?

www.fastcompany.com/90375683/an-...

This October I’m drawing one molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social

Day 2/31
Prompt WEAVE

N-terminal domain of a Fibrion - a building block of silk fiber produced by silkworms.

Pdb: 3UA0

Next prompt is CROWN and I would love your suggestions!

As a little boy, my grandparents gave me this book. This story of Pasteur is the one that made me want to be a scientist. And it doesn’t even mention optical activity!!

It’s Nobel time. Experts predict who will nab the 2025 chemistry prize The audience of C&EN's Nobel-prediction webinar votes for obesity drug pioneers to win

Who will win the #ChemNobel? cen.acs.org/people/nobel... #chemsky 🧪

As a little boy, my grandparents gave me this book. This story of Pasteur is the one that made me want to be a scientist. And it doesn’t even mention optical activity!!

Trump strikes deal with Pfizer aimed at lowering prescription drug prices Pfizer will offer discounted prices on some of its drugs and avoid U.S. tariffs, in a deal with President Trump.

President Trump announced on Tuesday that Pfizer has agreed to offer lower prices on its drugs to the Medicaid program and directly to patients
www.statnews.com/2025/09/30/t...

I rarely post about work, but in writing this email today asking how to be reimbursed for the cost of hosting a scientific visitor I wrote this explainer. This is not a complaint - but shows how we have to use our own salaries to enrich our environment and the commitment that takes

Secretary Kennedy Swears in Dr. Anthony Letai as Director of the National Cancer Institute Dr. Letai will serve as NCI’s 18th director.

We want to congratulate our President, Dr. Tony Letai, on his appointment as Director of the NCI. This announcement marks an historic moment for cancer research. Dr. Letai has been a tireless advocate and visionary leader for functional precision medicine 🧵

www.nih.gov/news-events/...

“dad can you can get me one of those retro digital cameras?”

It reminds me of this banger:

"Revised Estimates for the Number of Human and Bacteria Cells in the Body"

- We estimate the total # of bacteria in the 70 kg "reference man" to be 3.8X10^13.
- # of bacteria in the body is actually of the same order as the # of human cells, & total mass is ~0.2 kg.

I missed this paper at the time but love this kind of study:

"The total mass, number, and distribution of immune cells in the human body"

"an average individual’s immune system consists of approximately 1.8 trillion cells, weighing around 1.2 kg"

www.pnas.org/doi/10.1073/...

I rarely post about work, but in writing this email today asking how to be reimbursed for the cost of hosting a scientific visitor I wrote this explainer. This is not a complaint - but shows how we have to use our own salaries to enrich our environment and the commitment that takes

When the day is done

Meeting my trainee for coffee and project strategizing in the amazing NIH Clinical Center. Inspiring.

Merch!

One of the posters from my group was on a drug discovery strategy for inhibitors of biliverdin reductase - a target relevant for several rare diseases. Our postbac Christa did an amazing job presenting her work - it’s a collab with scientists at Einstein.

Meeting my trainee for coffee and project strategizing in the amazing NIH Clinical Center. Inspiring.

But the poster sessions are buzzing - so much amazing NIH science on show! I got in trouble for standing on a ledge to take this photo….. you’re welcome

It’s that time of year again - NIH Research Festival !

But the poster sessions are buzzing - so much amazing NIH science on show! I got in trouble for standing on a ledge to take this photo….. you’re welcome

Sometimes you make a poster, then realize the world isn’t ready

Merch!

It’s that time of year again - NIH Research Festival !

I must be doing something right - daughter raided my vinyl.