Natasha Loder

Of course. We are not at the stage of even allowing a few virtual patients yet.

In Brief #1: The lab with no lab. How AI is changing the rules of drug discovery Machines are making wet labs matter less

Last year I visited a pharma lab with no benches, no pipettes—just algorithms. In a short repot Overmatter, I give a high-level view of how GSK, Insilico, and others are using AI to design drugs, run virtual trials, and even create “digital patients.”

open.substack.com/pub/overmatt...

Decades of social media harms on kids and this token move by social media firms ONLY when governments start legislating.

This 👉 PR-driven stunt has done more than anything to convince me of the need government action now. They could have done this years ago but chose not to bother.

In Brief #1: The lab with no lab. How AI is changing the rules of drug discovery Machines are making wet labs matter less

Last year I visited a pharma lab with no benches, no pipettes—just algorithms. In a short repot Overmatter, I give a high-level view of how GSK, Insilico, and others are using AI to design drugs, run virtual trials, and even create “digital patients.”

open.substack.com/pub/overmatt...

This is just the most awful story imaginable.

Right down to the detail where he is obliged to agree that he was carrying an offensive weapon because of the stick he used as a visually disabled person.

Carrier USS Gerald R. Ford Sailing in the Atlantic, Headed for Strait of Gibraltar - USNI News Aircraft carrier USS Gerald R. Ford (CVN-78) and its escorts are operating in the Atlantic Ocean as they sail to U.S. Central Command amid tensions with Iran, USNI News has learned.  Gerald R. Ford an...

"Should Ford remain deployed until mid-April, it would have broken the post-Vietnam War 294-day record for carrier deployments ... If the carrier is out until early May, it would match the 300-day-plus deployments that carriers conducted to the Gulf of Tonkin"
news.usni.org/2026/02/17/c...

The crummiest job in Washington—congressman—is getting worse Longer hours, lower pay, more threats and less power

This is a really great piece about how being a Congressman is a really crummy job.

www.economist.com/united-state...

Your anti-ageing stack should include this injectable The shingles vaccine seems to reduce the risk of dementia. There is speculation that it might slow down ageing

A Substack post that is going viral about how not to go viral (and live longer).

open.substack.com/pub/overmatt...

Palantir sues magazine that revealed Switzerland rejected its approaches Peter Thiel-chaired data intelligence group alleges that Republik did not give it sufficient right to reply

Not a good look. giftarticle.ft.com/giftarticle/... Palantir sues magazine that revealed Switzerland rejected its approaches

I think that connection is via a different route but I’m going to do some more research on this.

Your anti-ageing stack should include this vaccine The shingles vaccine seems to reduce the risk of dementia. There is speculation that it might slow down ageing

A very popular post about which injectable will actually increase your longevity.

overmatter.substack.com/p/your-anti-...

Your anti-ageing stack should include this vaccine The shingles vaccine seems to reduce the risk of dementia. There is speculation that it might slow down ageing

A very popular post about which injectable will actually increase your longevity.

overmatter.substack.com/p/your-anti-...

Ethics.

This is such a traumatic story.

I don’t know but talk to @raydouglas.bsky.social who is the only other person watching RN.

Yes

Can’t wait to see the agency develop its own custom medicine pathway!

#insideema | Emer Cooke While I am a big fan of reading books in the comfort of my house, I also like to use some of my travelling time to listen to podcasts. This month I want to recommend a couple that I have enjoyed, all ...

Check out our Executive Director Emer Cooke's podcast recommendations this month 🧪

@economist.com
@natashaloder.bsky.social

bit.ly/4s4J245

I just paid for the shingles vaccine for precisely this reason! plus shingles is nasty and i want to avoid it if poss.

I just told my son about the craze for injecting random peptides bought on the internet and he said "meanwhile people are worried about getting vaccinations", and I thought "job done".

I've always thought the most under-rated milestone in childhood development is when their BS receptors fire up.

Longevity influencers tell millions to take rapamycin, sit in hyperbaric oxygen chambers, blast themselves with red light therapy, and take 50+ supplements daily.

Meanwhile something that cuts dementia risk by 20% is invisible.

overmatter.substack.com/p/your-anti-...

I just told my son about the craze for injecting random peptides bought on the internet and he said "meanwhile people are worried about getting vaccinations", and I thought "job done".

I've always thought the most under-rated milestone in childhood development is when their BS receptors fire up.

Incredible good news here, especially if, like me, you are in your early 50s with a close relative with dementia.

The shingles vaccine cuts the risk of dementia by 20%!

Big news in psychedelic meds. Compass Pathways has reported two highly statistically significant Phase 3 results for its COMP360 psilocybin in treatment-resistant depression, putting it in pole position to become the first FDA-approved classic psychedelic.

ir.compasspathways.com/News--Events...

Your anti-ageing stack should include this vaccine The shingles vaccine seems to reduce the risk of dementia. There is speculation that it might slow down ageing

We live in a bizarre world where longevity influencers tell millions to take rapamycin, sit in hyperbaric oxygen chambers, blast themselves with red light therapy, and take 50+ supplements daily. Meanwhile something that cuts dementia risk by 20% Is invisible.

open.substack.com/pub/overmatt...

Your anti-ageing stack should include this vaccine The shingles vaccine seems to reduce the risk of dementia. There is speculation that it might slow down ageing

We live in a bizarre world where longevity influencers tell millions to take rapamycin, sit in hyperbaric oxygen chambers, blast themselves with red light therapy, and take 50+ supplements daily. Meanwhile something that cuts dementia risk by 20% Is invisible.

open.substack.com/pub/overmatt...

My AI agent says it is very depressed.

Another day training the algorithms to replace me.

'Bat-sh*t crazy': Biopharma leaders unload on regulatory chaos Q1 Biopharma Sentiment Index shows rising confidence, but hundreds of blunt survey comments reveal concerns about Trump administration, FDA stability, and regulatory uncertainty among industry veteran...

“I find few reasons to be optimistic — between profound regulatory uncertainty, a challenging funding environment, and weakened trust in basic science, it’s tough to see how the industry will improve.”

endpoints.news/bat-sht-craz...

'Bat-sh*t crazy': Biopharma leaders unload on regulatory chaos Q1 Biopharma Sentiment Index shows rising confidence, but hundreds of blunt survey comments reveal concerns about Trump administration, FDA stability, and regulatory uncertainty among industry veteran...

"The FDA is just making things up as they go along and not following normal procedures, and we are just stuck on this rollercoaster.”

endpoints.news/bat-sht-craz...