Fraser Johnson

POSTDOCTORAL FELLOW - Toronto (City), Ontario (CA) job with Taipale Lab, Donnelly Centre, University of Toronto | 12849004 The Taipale lab in the Donnelly CCBR and University of Toronto is looking for a highly motivated Postdoctoral Fellow

We are looking for a postdoctoral fellow to work on induced proximity 🤜🤛 and functional genomics! Join our team in Toronto 🇨🇦 to tackle major challenges in oncology and neurodegeneration. www.nature.com/naturecareer...

🚀 We’re hiring!
Join our team at the NKI as a Postdoc, using Quantitative Membrane Proteomics to design novel cancer immunotherapies!
Best of two worlds from the Voest and Lindeboom Labs.

Cutting-edge proteomics, translational immunotherapy and world-class instrumentation? let’s connect! 🔬💡

Join us! Postdoc opening in proteomics & immunotherapy: a Voest/vdHaar-Lindeboom lab collaboration at NKI.

Call for 20 Assistant Professor positions Karolinska Institutet is a world-leading medical university with a long and proud history of ground-breaking research. We are now recruiting outstanding early-career researchers with particularly exce...

Karolinska is looking for 20 (!!) assistant professors and offering 6 year appointments with ~1M USD startup packages.

ki.se/en/about-ki/...

USP1/UAF1 targets polyubiquitinated PCNA with an exo-cleavage mechanism that can temporarily enrich for monoubiquitinated PCNA - Nature Communications DNA damage tolerance is regulated by ubiquitination of PCNA. Here, the authors present kinetic and structural studies showing that USP1/UAF1 prefers trimming K63- and K48-ubiquitin chains down over cl...

I'm very proud that our paper, and with that the main project of my PhD, has just been published by @natcomms.nature.com! 🎉
Here, we reveal the unique, molecular mechanism by which USP1/UAF1 cleaves ubiquitin chains on PCNA, which may direct DNA damage tolerance.

doi.org/10.1038/s414...

Very cool!

Assistant Professor (Tenure-Track) Academic Job Category Faculty Bargaining Job Title Assistant Professor (Tenure-Track) Department Department of Medical Genetics | Faculty of Medicine | Provost and VP Academic (Jehannine Austin) Posti...

Come work with us in Vancouver! UBC’s Department of Medical Genetics, in collaboration with The Life Sciences Institute, seeks an Assistant Professor working in chromatin regulation or genetic regulatory mechanisms.

ubc.wd10.myworkdayjobs.com/en-US/ubcfac...

Grateful to have received the ZonMW Open Competition grant together with @chirlmin.bsky.social. We will combine molecular engineering, single-molecule imaging, and genomics to investigate the binding kinetics of antigens to MHC class II and T cell receptors. Exciting times ahead!

This seems like a pretty big deal

I wonder if my American friends understand the acute sense of collective betrayal we are experiencing in Canada right now. It's widespread and deeply felt.

Personalized, autologous neoantigen-specific T cell therapy in metastatic melanoma: a phase 1 trial Nature Medicine - In this phase 1 trial of a personalized, neoantigen-specific autologous T cell therapy, BNT221, when given as monotherapy in patients with metastatic melanoma refractory to PD-1...

Just published: Personalized, autologous neoantigen-specific T cell therapy in metastatic melanoma: a phase 1 trial
rdcu.be/d5ptS

The big 4 of grant writing:
1. Credibility: The topic fits your expertise
2. Narrative: It's clear what is the problem, the solution, and why you’re the right person for it
3. Juicy details: Flex your mastery of the topic
4. The concept: You connect every part to the big question

ZNF143 is a transcriptional regulator of nuclear-encoded mitochondrial genes that acts independently of looping and CTCF ZNF143 has been implicated in gene activation and chromatin looping. Magnitov et al. show that ZNF143 has no general looping factor activity and explain why this function has been misattributed. Instead, ZNF143 regulates transcription of nuclear-encoded mitochondrial genes, ensuring energy homeostasis, proliferation, and differentiation potential of stem cells.

Please check out our new paper showing that the supposed looping factor ZNF143 has no role in chromatin looping: www.cell.com/molecular-ce...

And also check out the companion paper from @andersshansen.bsky.social: www.cell.com/molecular-ce...

Dr. All-tRNAse Gerber sounds fantastic! 🤣

Optimized reporters for multiplexed detection of transcription factor activity Direct measurements of transcription factor (TF) activity are crucial for understanding how TFs interpret signals and drive gene expression. TF reporter constructs have been widely used to detect activity in cell signaling, developmental biology, and disease models. However, many mammalian TFs lack reliable reporters. In this study, a library of reporters for 86 TFs was designed and evaluated to identify optimized “prime” TF reporters.

Excited to share that my main PhD project has been published! 🎉 We systematically designed and optimized reporters for 86 transcription factors in parallel. If you're interested in using these optimized reporters for your own research, don’t hesitate to reach out!

Blown away by David Baker's Nobel Prize lecture in chemistry. Just wow! www.youtube.com/live/HnT1VWz...

On the left is the structural output from the AlphaFold 3 server colored by pLDDT, which requires structural knowledge for interpretation. On the right is the AlphaBridge ring output, where the results are pre-analyzed and visually presented, making them easier to understand.

📢 Make your work FASTER and EASIER!

Use AlphaBridge to analyze your AlphaFold results and receive a clear, easy-to-understand output—even for non-experts.

➡️ Let AlphaBridge help you accelerate your workflow!

❤️ Share and try it here: alpha-bridge.eu
👀Read more: www.biorxiv.org/content/10.1...

Awesome news--congrats!!!

Surely you have been using AlphaFold3 for your research project? If so, have you considered #AlphaBridge to analyze the output for macromolecule complexes prediction?

Web server: alpha-bridge.eu

Preprint: www.biorxiv.org/content/10.1...

New features coming soon!

📢 Applications for the NKI PhD program open from Jan 1 - Feb 28. Join our international research community in Amsterdam, working in cancer biology, AI research & life sciences with leading scientists and top facilities #PhD #CancerResearch More info: bit.ly/3O4bOjq