Yahaya Yabo

Happy to see this amazing work finally out. We used our NePSTA model to acurately predict the epigenetic subtypes of meningiomas based on cell-type abundance in subgraphs containing gene expression features + spatial adjacency.

Immunosuppressive mechanisms and therapeutic interventions shaping glioblastoma immunity - Nature Cancer In this Review, Golebiewska and colleagues summarize the main features of the immunosuppressive microenvironment in glioblastoma (GBM) and discuss how different therapeutic approaches reshape GBM immu...

Can immunotherapy ever work in #glioblastoma?

In a new #NatureCancer review, we share our perspective on current limitations and future directions:
www.nature.com/articles/s43...

#NORLUX, #LIH , @fnr.lu #TELEVIE, @glioresolve.bsky.social, @michael-platten.bsky.social

Serotonergic neuron-glioma interactions drive high-grade glioma pathophysiology High-grade gliomas are lethal brain cancers that are powerfully regulated by glutamatergic neurons through activity-dependent paracrine factors and functional neuron-to-glioma synapses. Here, we repor...

www.biorxiv.org/content/10.6...

Happy to share a new #NORLUX study on how humanized patient-derived xenografts of #glioblastoma can be useful in investigating immunosuppression and clinically-relevant immunotherapy testing. See for more: www.biorxiv.org/content/10.1...
#immunotherapy, #preclinicalmodeling,

Amazing Keynote talk by @heilandhenrik.bsky.social on "Translational Data Integration and Technological Developments in Neuro-Oncology" at the ongoing #SNO2025 in Hawaii.🧠

Be sure to check the @milolab.bsky.social talks including our work on "Deciphering spatiotemporal trajectories of tissue adaptation after surgical resection of glioblastoma."

#EANO2025 was awesome. Great time interacting with mentors and colleagues. Looking forward to another exciting meeting.

Just wrapped up an incredible few days in Prague for the @eanoassociation.bsky.social meeting! Truly inspiring sessions, great discussions, and exciting new collaborations. The MILO Lab shined with engaging talks and eye-catching posters! Ready to keep pushing the boundaries of science together!

📢 @eanoassociation.bsky.social 2025 kicks off today in Prague!

Proud to see strong #EORTC representation with six abstracts and a joint session with BTG featuring EORTC-led projects on clinical trial planning.

More info 👉 www.eortc.org/blog/2025/10...

#EANO2025 #NeuroOncology @qol.eortc.org

Integrative multi-omics combined with functional pharmacological profiling in patient-derived organoids identifies personalized therapeutic vulnerabilities of adult high-grade gliomas Background: Precision medicine has transformed cancer treatment by tailoring therapies to specific molecular aberrations. Integrating high-resolution multi-omics with high-throughput functional profil...

Precision medicine in high-grade gliomas? Using high-throughput drug screen in #NORLUX patient-derived organoids multi-omics and machine learning, we assessed pharmacogenomics: www.biorxiv.org/content/10.1...
@fnr.lu, #precisionmedicine, #organoids, #drugscreen, #pharmacogenomics, #braintumors

Thanks Roman.

NEW content online!

Happy to share a short "tools of the trade" piece on our NeuroPathology Spatial Transcriptomic Analysis (NePSTA) tool. Now available @natrevcancer.nature.com www.nature.com/articles/s41...

#microglia and other tissue #macrophages are highly plastic. This makes them look differently depending on their respective context. Granular methods like #single-cell sequencing are merely snapshots that may simplify the complexity found in the tissue. In our perspective in @natneuro.nature.com

How does tumour heterogeneity arise? How can we predict cancer cell plasticity? In 2 new studies, we trace #glioblastoma heterogeneity to a spatial cancer cell trajectory w. multimodal cell atlassing bit.ly/4mkrWgs & predict plasticity w. snRNA/ATAC+deep learning bit.ly/3FbI6Ic 🧵

Decoding Plasticity Regulators and Transition Trajectories in Glioblastoma with Single-cell Multiomics Glioblastoma (GB) is one of the most lethal human cancers, marked by profound intratumoral heterogeneity and near-universal treatment resistance. Cellular plasticity, the capacity of cancer cells to t...

Two massive glioblastoma papers, datasets, trajectories, insights, and.. a very cool new method for GRN inference - scDORI -from @steglelab.bsky.social @oliverstegle.bsky.social @bayraktarlab.bsky.social & Moritz Mall www.biorxiv.org/content/10.1... www.biorxiv.org/content/10.1...

The multilayered transcriptional architecture of glioblastoma ecosystems - Nature Genetics Integrated single-cell transcriptomic and genetic characterization of 121 adult glioblastomas identifies heterogeneity at cell type, cell state and baseline expression program levels associated with s...

1/ Thrilled to share our TWO back-to-back papers published in Nature Genetics today! www.nature.com/articles/s41... , www.nature.com/articles/s41...

Finally, the GBmap paper is out after over 80 citations of the preprint version. Congratulations @ccruizm.bsky.social 🎉

Putting cancer immunotherapy into spatial context in the clinic - Nature Biotechnology Spatial omics technologies offer insights into the organization of cellular and molecular components and their interactions within the tumor ecosystem. Overcoming the key challenges to integrating the...

Putting cancer immunotherapy into spatial context in the clinic - @joakimlundeberg.bsky.social @scilifelab.se @ki.se go.nature.com/4jlus4b

The @milolab.bsky.social retreat was lit 🔥. I am grateful and lucky to be in this amazing group.
Great people, great science.
#glioblastoma #spatialtranscriptomics
#scRNA-seq

Congratulations to Annette. Well deserved.

📣 Open computational PhD & Postdoc positions!

Excited about the open positions as part of our newly funded Emmy Noether Group are online now under
kocakavuklab.vercel.app/joinus

📢 Please RT (what's the bsky equivalent here?) and distribute !

👇A quick instruction on how to apply

GABAergic neuron-to-glioma synapses in diffuse midline gliomas - Nature Functional, tumour-promoting GABAergic neuron-to-glioma synapses in diffuse midline gliomas are identified.

Nature research paper: GABAergic neuron-to-glioma synapses in diffuse midline gliomas

https://go.nature.com/434f4ns

🎗️ Today is #WorldCancerDay – a reminder of the ongoing fight against cancer and the need for research, collaboration & innovation in all types, including #NeuroOncology. At #EANO, we’re dedicated to advancing science and patient care. Together, we can make a difference! 💙

Beautiful work from @tobiw2024.bsky.social and @rsankowski.bsky.social

Happy to share our recent investigation of the spatial architecture of benign and malignant peripheral nerve sheath tumors.
@10xGenomics

🚨Spoiler Alert: We identified APOD in neurofibroma regions as a novel biomarker in hybrid PNSTs

t.co/GmA9MLNKy1

Ever wondered what makes brain tumors tick?
Excited by the breakthroughs in spatial transcriptomics and single-cell analysis? Follow @milolab.bsky.social account on Instagram: cutting-edge insights, updates, and engaging content!

www.instagram.com/the_milolab/...

Spatially resolved transcriptomics and graph-based deep learning improve accuracy of routine CNS tumor diagnostics - Nature Cancer Ritter et al. present a spatial transcriptomics and deep learning-based approach named NePSTA (neuropathology spatial transcriptomic analysis) and leverage it to improve neuropathological diagnostics ...

Happy to share your latest collaboration with
@sahm_lab
leveraging spatial transcriptomics
@10xGenomics
for neuropathology diagnosis #DeepLearning
! 107 patients across 15 CNS tumors!

www.nature.com/articles/s43...

Happy to be part of this beautiful work from @milolab.bsky.social and Sahm lab.
Using deep learning to enhance brain tumor diagnosis. From spatial transcriptomics data you can predict tissue histology, methylation subclass, genotype, immunohistochemistry etc.

Spatially resolved transcriptomics and graph-based deep learning improve accuracy of routine CNS tumor diagnostics - Nature Cancer Ritter et al. present a spatial transcriptomics and deep learning-based approach named NePSTA (neuropathology spatial transcriptomic analysis) and leverage it to improve neuropathological diagnostics ...

New insights on #machineLearning #glioblastoma and other brain #tumors by the Heiland and Sahm labs

Spatially resolved transcriptomics and graph-based deep learning improve accuracy of routine CNS tumor diagnostics | @naturecancer.bsky.social

www.nature.com/articles/s43...