FOR5596 - SAM-dependent enzyme chemistry

SCIENCE & TECHNOLOGIE Science & Technologie führt Kinder und Jugendliche an Themen in den Bereichen Wissenschaft und Technologie heran.

science-days.de

22.10.2025 14:52 — 👍 0    🔁 0    💬 0    📌 0

We are preparing for the Science Days at Europa-Park (23.-25.10.25). We are encouraging pupils to pursue STEM!

22.10.2025 14:51 — 👍 1    🔁 0    💬 1    📌 0

Greetings from all of our members at the three-day annual meeting in St. Peter in 2025. Thank you for a successfull year filled with hard work, collaboration, great ideas and a lot of motivation for our future research.

14.10.2025 11:39 — 👍 0    🔁 0    💬 0    📌 0

We are also looking forward to the presentations by Dr. Anna Vagstad and our group member, Tenure-Track Professor Dr. Lena Barra @barra-lab.bsky.social, at the Young Researchers Session in Irsee.

08.09.2025 13:29 — 👍 2    🔁 0    💬 0    📌 0

@rentmeisterlab.bsky.social

08.09.2025 13:28 — 👍 1    🔁 0    💬 0    📌 0

We are organizing a session on SAM-dependent enzymes at the 38th Irsee Natural Product Symposium, February 25-27, 2026. We are pleased to welcome the following speakers:
Prof. Andrea Rentmeister, Prof. Jörg Pietruszka, and Prof. Andreas Kirschning.

Please spread the news and join us in Irsee!

08.09.2025 13:15 — 👍 2    🔁 0    💬 2    📌 1

Greetings to all the doctoral researchers of the FOR5596 research unit who spent the last week at a summer school in Berlin!

02.07.2025 11:22 — 👍 0    🔁 0    💬 0    📌 0

Congratulations to FOR5596 member Andrea @rentmeisterlab.bsky.social for receiving the Wittig-Grignard Award!! 🎉

30.04.2025 15:34 — 👍 1    🔁 0    💬 0    📌 0

Of course, also greetings to @seebecklab.bsky.social @nicocorn.bsky.social and all the other authors <3

17.04.2025 08:46 — 👍 1    🔁 0    💬 0    📌 0

Biomimetic S‐Adenosylmethionine Regeneration Starting from Multiple Byproducts Enables Biocatalytic Alkylation with Radical SAM Enzymes** The biomimetic regeneration system for S-adenosylmethionine (SAM) and SAM analogues presented is based on the salvage of the adenine moiety and in situ supply of d-ribose and polyphosphate. It is com...

Congratulations to all the authors of this paper, which just ranked in the top 10% of the most viewed papers published in ChemBioChem in 2023! We are very excited to be able to build on this amazing work in our FOR5596 research group.

@andexerlab.bsky.social @rentmeisterlab.bsky.social

17.04.2025 08:38 — 👍 5    🔁 1    💬 1    📌 1

Chimeric cofactors enable methyltransferase-catalyzed prenylation In nature, many methyltransferases (C1) use S-adenosyl-l-methionine (AdoMet or SAM) as a cofactor for methyl transfer, whereas prenyltransferases (C5) use dimethylallyl diphosphate (DMAPP). We enginee...

Ever wondered why prenylation and methylation use different cofactor scaffolds? We now show that the SAM scaffold enables both: Chimeric cofactors enable methyltransferase-catalyzed prenylation: Chem www.cell.com/chem/fulltex... Kudos to @nicocorn.bsky.social & Arne Hoffmann and all authors 👌👏🤩

09.04.2025 18:00 — 👍 10    🔁 2    💬 0    📌 0

New FOR5596 paper from the Müller, Garcia Borràs and Andexer groups!

04.04.2025 15:38 — 👍 0    🔁 0    💬 0    📌 0

How to Tell an N from an O: Controlling the Chemoselectivity of Methyltransferases S-Adenosyl-l-methionine (SAM)-dependent methyltransferases (MTs) are important enzymes in numerous biological pathways. They share a common SN2 mechanism but act on different nucleophilic substrates i...

If you want to know how to tell an N from an O, you can get some ideas in our new paper. This was a great team effort, introducing us to new methods: MD w/ Ferran Feixas & Marc Garcia Borràs (Girona) + HDX-MS w/ Wieland Steinchen & Gert Bange @bangebalcony.bsky.social
pubs.acs.org/doi/10.1021/...

04.04.2025 15:36 — 👍 2    🔁 2    💬 1    📌 0

logo of research group FOR 5596 on SAM-dependent enzyme chemistry showing the chemical structure of S-adenosylmethionine

FOR 5596 is now on BlueSky! Follow us to stay informed about our collaborative project "Unfolding the potential of SAM-dependent enzyme chemistry".

02.04.2025 14:20 — 👍 3    🔁 2    💬 0    📌 0