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Marc Dionne

@marcsdionne.bsky.social

Innate immunity, bacterial infection, physiology, microbiology, Drosophila. Poorly focused. Still angry. Professor, Department of Life Sciences and Centre for Bacterial Resistance Biology, Imperial College London.

1,362 Followers  |  1,312 Following  |  634 Posts  |  Joined: 17.08.2023  |  2.329

Latest posts by marcsdionne.bsky.social on Bluesky

I'm sad to report that my native land currently leads the world in fucking guys

30.10.2025 18:00 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

this may qualify as a hot take

30.10.2025 17:42 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

just as long as it's not Science

27.10.2025 15:56 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

publish in Nature, get a free set of steak knives

27.10.2025 11:51 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

knows how to accessorize

27.10.2025 07:23 β€” πŸ‘ 6    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

time is a flat circle with a curl of citrus peel

24.10.2025 11:19 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Preview
Cattle bovine TB vaccine field trials move to next phase Read about our Cattle Vaccine Project: APHA’s invaluable addition to the toolbox to eradicate bovine TB in the UK.

Do cows count? Admittedly, not stated whether or not it's administered IV aphascience.blog.gov.uk/2025/10/21/c...

23.10.2025 19:57 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Isn't that how evolution works? In the beginning, all expression was constitutive

22.10.2025 08:44 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Stay tuned for my theory about how the immune system controls antimicrobial activity by changing the interest rate on amino acid swaps

22.10.2025 08:31 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
the blue screen of death from a computer, running Windows 7, that has had to restart

the blue screen of death from a computer, running Windows 7, that has had to restart

extra points if you could take down the whole system

22.10.2025 06:51 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

when I'm in bash I feel as though I'm some kind of 1337 h4x0r but in R it's just like, you know, work

22.10.2025 06:30 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Dear funding agencies,

I know we all want to discover the wonder drug that will cure the horrible diseases, but to do that, we need to invest in basic, unsexy, foundational research on how the systems work. Funding can’t all be drug development.

Sincerely,
Looking for basic research grants.

14.10.2025 19:24 β€” πŸ‘ 2310    πŸ” 390    πŸ’¬ 43    πŸ“Œ 14

I totally understand. I just wanted to offer reassurance that our world, dystopian as it can seem, is not *that* bad. Yet.

14.10.2025 12:44 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

That is not true. It *is* true that there are specific funding opportunities for using AI in science, but that's not most of the funding available, and the AI in question is not the kind of AI autofill slop generation that we're all so sadly used to.

14.10.2025 11:05 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
Preview
Reaffirming the value of model organisms in training scientific minds - Nature Cell Biology As biomedical research prioritizes human models and translational promise, classic model organisms are increasingly dismissed. Here we argue that they have a lasting value, both in enabling discovery and in cultivating scientific thinking, by training researchers in systems reasoning, integrative thinking and independent inquiry.

Model organisms, in particular non-mammalian model organisms, such as yeast, Caenorhabditis elegans, #Drosophila and zebrafish, have long stood at the centre of biological discovery www.nature.com/articles/s41...

11.10.2025 08:03 β€” πŸ‘ 45    πŸ” 26    πŸ’¬ 0    πŸ“Œ 0

People point to the Tories broader record in government but them leaning on Ofcom to leave GB News alone despite its repeated regulatory breaches & its star presenter being a political rival of theirs may actually be the thing that dooms them

Naturally, Labour are refusing to correct this mistake

09.10.2025 09:35 β€” πŸ‘ 17    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0

she was easy to track down

09.10.2025 11:39 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

well, it *does* make me cranky when my stomach hurts

09.10.2025 11:34 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

"The work I was involved in had no obvious therapeutic benefit. It was purely of scientific interest. I hope the country will continue to support basic research even though it may have no obvious practical value."
- John Gurdon

07.10.2025 17:46 β€” πŸ‘ 42    πŸ” 11    πŸ’¬ 1    πŸ“Œ 0

I can't really complainβ€”somebody gave me a confocal once. Sadly, it's dead now.

07.10.2025 20:17 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

envious

07.10.2025 18:19 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

are you referring to the speaker of the house of representatives as "shit Ilan Wurman"

07.10.2025 14:33 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

I've only read Bleeding Edge once (you've made me want to read it again)β€”but this is interesting given the comments in the introduction to Mirrorshades that Gibson and Sterling and the other early cyberpunks were unified in their worship of Pynchon.

07.10.2025 11:55 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

but in that case, it's not a real Kavanaugh stop, because there's a legitimate cause for suspicion

02.10.2025 11:20 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

UK numbers look large because of (relatively) large numbers of events early in the time series. It's interesting how UK falls behind Germany, then France and Canada at the very end. Gun control appears to be highly effective at reducing gun deaths.

01.10.2025 16:24 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

as I recall, the last time I paid attention to this, this was an accurate statement of the full extent of our mechanistic understanding of the adjuvanticity of alum

01.10.2025 08:14 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Hm is it bad if the industry somehow propping up a trembling economy is based almost entirely on our collective willingness to let it do crimes

30.09.2025 10:57 β€” πŸ‘ 134    πŸ” 26    πŸ’¬ 2    πŸ“Œ 1

second prize is two mosquitoes

29.09.2025 20:36 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

mosquoin, surely

29.09.2025 20:34 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

folate deficiency

25.09.2025 11:13 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

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