Mireya Plass

Bulk RNA-seq to the rescue of differential expression analysis i... Due to the costs of single-cell sequencing, sample sizes are often relatively limited, sometimes leading to poorly reproducible results. In many contexts, however, larger bulk RNAseq data is…

"Bulk RNA-seq to the rescue of differential expression analysis in single-cell transcriptomics" 🧫 📑 A new PCI Genomics recommendation by @mireyaplass.bsky.social: doi.org/10.24072/pci...

🚨Interested in studing RNA regulation & neurodegeneration in single-cells?
Join my lab @ub.edu in Barcelona!
We are looking for a junior postdoc to apply for a Juan de la Cierva fellowship. Both computational and hybrid candidates are welcomed! Get in touch to discuss the project & details

Hey everyone! I’m excited to share that one of my thesis projects was just published in @currentbiology.bsky.social and featured on phys.org! In this paper, we use an old statistical approach developed by the US Navy in WW2 to predict the aquatic habits of various dinosaurs and marine reptiles 🦖🐊

¡Ya llevamos 212.352€ recaudados! Estamos más cerca que nunca de lograr crear el algoritmo capaz de anticiparse al Alzheimer. Ayúdanos a seguir investigando 🧠🔬.

Dona ahora en anticiparsealalzheimer.org

Integrated analysis of multimodal long-read epigenetic assays https://www.biorxiv.org/content/10.1101/2025.11.09.687458v1

🚨Interested in studing RNA regulation & neurodegeneration in single-cells?
Join my lab @ub.edu in Barcelona!
We are looking for a junior postdoc to apply for a Juan de la Cierva fellowship. Both computational and hybrid candidates are welcomed! Get in touch to discuss the project & details

🚨 We're hiring! 🚨 Our lab at the University of Málaga, Spain🇪🇸 is looking for a bioinformatician researcher for a postdoc position (1+1 years). Check the ad, and if you're interested, get in touch!
📅 Starting date early 2026, with some flexibility.
🙏Please, RT!

Finally after 5 years the first PhD from the lab!
Congratulations Dr. Ake @franzake.bsky.social !!! 👏👏👏 🎉🎉🎉
It has been a pleasure to have you in the lab. #PhD_defense #new_PhD

Excited and grateful to be part of this work with @smfernandezmoya.bsky.social and @mireyaplass.bsky.social at the Gene Regulation of Cell Identity lab!

Staufen2 modulates the temporal dynamics of human neurogenesis in vitro RNA-binding proteins (RBPs) play a central role in post-transcriptional regulation during brain development, yet their specific functions in coordinating human neural lineage decisions remain poorly u...

🚨New preprint from the lab! This work led by @akshayjg.bsky.social & @smfernandezmoya.bsky.social shows how the RNA binding protein STAU2 regulates the timing of neurogenesis in iPSC-derived human cells
www.biorxiv.org/content/10.1...

This project would have been impossible without the work of our collaborators Agnieskza Rybak-Wolf, @monikapiwecka.bsky.social & Alessandra Gioregtti.

If you wanna know all the details about the role of this interesting protein, please read the full pre-print on bioRxiv!
#RBP #neurogenesis #iPSCs #scRNA-seq #STAU2

Which leads to an accelerated differentiation and depletion of the neural progenitor pool in both 2D cultures and organoids

In neuroepithelial cells, STAU2 controls the activity of Gene regulatory networks important for the maintenance of Stem Cell Profile

Using single-cell transcriptomics, we have found that STAU2 alters mainly the transcriptomic profile of neuroepithelial cells

Upon deletion of STAU2, we observe metabolic changes and accelerated differentiation of iPSCs

Staufen2 modulates the temporal dynamics of human neurogenesis in vitro RNA-binding proteins (RBPs) play a central role in post-transcriptional regulation during brain development, yet their specific functions in coordinating human neural lineage decisions remain poorly u...

🚨New preprint from the lab! This work led by @akshayjg.bsky.social & @smfernandezmoya.bsky.social shows how the RNA binding protein STAU2 regulates the timing of neurogenesis in iPSC-derived human cells
www.biorxiv.org/content/10.1...

#SENC2025 has just started. Looking forward to these 3 days showing the best neuroscience research in Spain.

Nice! Congratulations to all the team!

Core splicing architecture and early spliceosomal recognition determine microexon sensitivity to SRRM3/4 Nature Structural & Molecular Biology - Using massively parallel splicing assays and mathematical modeling, Bonnal et al. uncover that conserved splice site strength and exon length encode...

Very happy to share the peer-reviewed version of our work on the cis-regulatory determinants of #microexon #splicing regulation by SRRM3/4, published in @natsmb.nature.com!

rdcu.be/ezGqT

Work led by @sobonnal.bsky.social, with Simon Bajew & @rmartinezcorral.bsky.social. @crg.eu @upf.edu

Three major trends in comparative transcriptomics

🧬🧬🧬 New review from the lab:

Evolution of comparative transcriptomics: biological scales, phylogenetic spans, and modeling frameworks

authors.elsevier.com/sd/article/S...

By @mattezambon.bsky.social & @fedemantica.bsky.social, together with @jonnyfrazer.bsky.social & Mafalda Dias.

Call for Applications: Fully Funded PhD Scholarships in Systems Medicine - Human Technopole Are you passionate about science and ready to take the next step in your research journey? Human Technopole is offering up to 9 fully funded PhD scholarships through the highly regarded SEMM PhD Progr...

🎓 Just graduated and passionate about Computational #Biology, Structural Biology, #Genomics or #Neurogenomics? Apply by 8 Sept for 1 of 9 fully funded PhD scholarships via the SEMM Program at HT in Milan!

👉 humantechnopole.it/en/news/call... #PhDlife

If you like our recent work and are interested in developing a postdoc project related to isoform diversity in individual cell types and their regulation, get in contact!
We are looking for applicants for Marie Curie and EMBO postdoctoral fellowships #postdocposition #singlecell #RNA_processing

🚨🚨🚨

Please RT!

We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets.

Deadline: 30/09/25👇

Quantification of transcript isoforms at the single-cell level using SCALPEL - Nature Communications Single-cell RNA-seq facilitates the study of transcriptome diversity in individual cells. Here, authors introduce a tool for isoform quantification at the single-cell level using 3’ scRNA-seq data, co...

Quantification of transcript isoforms at the single-cell level using SCALPEL nature.com/articles/s41... by @miriplass.bsky.social and her team

Join our "Advances in Single-Cell Technologies" meeting in December in Freiburg, co-organised with Marco Prinz and @katrinkierdorf.bsky.social. Excellent line-up of speakers covering spatial technologies, lineage tracing, computational methods, and more.
www.uniklinik-freiburg.de/single-cell-...

L’estudi de #recercaUB sobre l'eina #SCALPEL que ha liderat @mireyaplass.bsky.social s’ha publicat el juliol en #openaccess a la revista @natcomms.nature.com.

🚨The #NextflowSummit Call for Speakers and Posters is Now Open! 🚨

🎤 Present your talk or poster at the Virtual #NextflowSummit by @seqera.io (Oct 23–24).
📍Or showcase your poster in-person in Barcelona at the Nextflow Training and @nf-co.re Hackathon (Oct 28–29)

hubs.la/Q03xGPp_0

Two new preprints from the @arjunraj.bsky.social‬ on #gastruloids. Both excellent. Exploring the relationship between macroscopic reproducibility v microscopic heterogeneity. Stunning experiments and much to think about
biorxiv.org/content/earl...
biorxiv.org/content/earl...

Quantification of transcript isoforms at the single-cell level using SCALPEL - Nature Communications Single-cell RNA-seq facilitates the study of transcriptome diversity in individual cells. Here, authors introduce a tool for isoform quantification at the single-cell level using 3’ scRNA-seq data, co...

A computational tool #SCALPEL for #isoform quantification at the single-cell level using 3’ scRNA-seq data @franzake.bsky.social @mireyaplass.bsky.social #BiotechNatureComms

doi.org/10.1038/s414...