Doeller Lab

Probabilistic Foundations of Fuzzy Simplicial Sets for Nonlinear Dimensionality Reduction Fuzzy simplicial sets have become an object of interest in dimensionality reduction and manifold learning, most prominently through their role in UMAP. However, their definition through tools from alg...

New preprint! Have you ever wondered, what are these fuzzy simplicial sets, the theoretical framework behind e.g. UMAP? Here we show that you may simply see them as marginal distributions over simplicial sets. This provides a generative model for UMAP. (1/2)

arxiv.org/abs/2512.03899

Interesting findings with important applications

Work co-first authored with @vigano.bsky.social, together with @bottinilab.bsky.social and @doellerlab.bsky.social
Preprint: doi.org/10.1101/2025...

Entorhinal grid-like codes for visual space during memory formation Nature Communications - Eye movements during scene viewing are tied to grid-like codes in the entorhinal cortex. Grid signals are specific to later remembered scenes, covary with activity in...

✨My first first-author paper is out✨
Entorhinal grid-like codes for visual space during memory formation in @natcomms.nature.com ➡️ rdcu.be/eLRm2
Big thanks to everyone ‪@isabellacwagner.bsky.social‬, @tobiasstaudigl.bsky.social, @olejensen.bsky.social, @doellerlab.bsky.social, @clauslamm.bsky.social

⏳ Deadline approaching! Apply by 13 Oct for the Postdoc in Cognitive Neuroscience at MPI Leipzig.

Dynamic updating of cognitive maps via traces of experience in the subiculum In the classical view of hippocampal function, the subiculum is assigned the role as the output layer. In spatial paradigms, some subiculum neurons manifest as so-called boundary vector cells (BVCs), ...

New preprint from the lab and great work by Fei Wang. We show how subiculum trace vector cells can be modeled consistent with known effects in CA1. Traces are driven by a mismatch learning rule to keep associative memories in line with experience.
www.biorxiv.org/content/10.1...

Join us at the Max Planck Institute in Leipzig as a Postdoc to explore cognitive maps in the human brain: learning, memory & the formation of structural representations. Excellent infrastructure with a leading scientific network. Apply by 13 October: postdocprogram.mpg.de/node/21187

Impact of Task Similarity and Training Regimes on Cognitive Transfer and Interference Learning depends not only on the content of what we learn, but also on how we learn and on how experiences are structured over time. To investigate how task similarity and training regime interact dur...

🚨 New preprint! Impact of Task Similarity and Training Regimes on Cognitive Transfer and Interference 🧠

We compare humans and neural networks in a learning task, showing how training regime and task similarity interact to drive transfer or interference.

www.biorxiv.org/content/10.1...

Congratulations to
@reznikdan.bsky.social
and
@sofievalk.bsky.social
for this tremendous achievement!

Efficient coding in working memory is adapted to the structure of the environment Working memory (WM) relies on efficient coding strategies to overcome its limited capacity, yet how the brain adaptively organizes WM representations to maximize coding efficiency based on environment...

Happy to share our new preprint. We found that brain adaptively switches between relational and item-based coding strategies based on the structure of memory contents.
@doellerlab.bsky.social

www.biorxiv.org/content/10.1...

Excellent outcome of #Algonauts2025 challenge by
@algonautsproject.bsky.social: Phase 1 winners, 2nd overall. Congratulations to everyone involved.

Impact of symmetry in local learning rules on predictive neural representations and generalization in spatial navigation Author summary The hippocampus is a brain region which plays a crucial role in spatial navigation for both animals and humans. Contemporarily, it’s thought to store predictive representations of the e...

Excited to share that our work on the interplay of symmetric learning rules and successor representations (SR) is published in @plos.org (comp.bio)

Work done together with @doellerlab.bsky.social, @caswell.bsky.social and Juergen Jost.

doi.org/10.1371/jour...
#neuroskyence #compneurosky

1/n

Who Does What in Deep Learning? Multidimensional Game-Theoretic Attribution of Function of Neural Units Neural networks now generate text, images, and speech with billions of parameters, producing a need to know how each neural unit contributes to these high-dimensional outputs. Existing explainable-AI ...

🚨Preprint Alert: Who Does What in Deep Learning? Multidimensional Contribution of Neural Units using Game Theory: arxiv.org/abs/2506.19732
The result of my MSc thesis is out with @kayson.bsky.social @fatemehhadaeghi.bsky.social @patrickmineault.bsky.social @kordinglab.bsky.social, Claus C. Hilgetag

📣 Very excited for our symposium on “Building Knowledge Structures” tomorrow at 16:30 at @pug2025.bsky.social

Together with amazing people:
@barnaveliirina.bsky.social
@lukaskunz.bsky.social @mirkothm.bsky.social
and Andrea Greve

Re-enacting steps supports human path integration consistent with motor-corrected grid cell drift Efficient navigation, especially in the absence of vision, requires path integration - the continuous updating of spatial position from self-motion cues. However, path integration is prone to cumulati...

New preprint! We explored how learned movement patterns affect our sense of traveled distance and proposed a neurocomputational model that leverages embodied memories to denoise spatial codes.

🔗 www.biorxiv.org/cgi/content/...

Our paper in @natcomms.nature.com, we show how cognitive maps in the hippocampal system could solve the general problem of representing and relating multiple alternative action plans. 
doi.org/10.1038/s414...

With @doellerlab.bsky.social, Patrick Haggard, @vigano.bsky.social, Daniel Reznik

🧠✨How do we rebuild our memories? In our new study, we show that hippocampal ripples kickstart a coordinated expansion of cortical activity that helps reconstruct past experiences.

We recorded iEEG from patients during memory retrieval... and found something really cool 👇(thread)

We’d love to chat—come find us at #CNS2025! 🙌
Posters B23, B85, C159, and C53

🌆 Evening Session (17:00–19:00)

📌 C159 — Foraging in conceptual spaces
👤 @vigano.bsky.social

📌 C53 — Neural Dynamics of Sequential Task Simulation in the Human Brain
👤 @nichome.bsky.social

🕗 Morning Session (8:00–10:00)

📌 B23 — Eye-movement pattern reveals optimal mental organization during memory encoding & maintenance
👤 Qiaoli Huang

📌 B85 — Investigating implicitly formed mental representations of abstract knowledge
👤 Irina Barnaveli

Come meet our lab at #CNS2025 today during the Poster Sessions! 🧠
We’re excited to share work on mental organization, knowledge representation, conceptual spaces & task simulation. Details are in the thread 👇